Cited by 158Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyReceptor Mechanisms and Signaling

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

NMDA receptors regulate GABA A receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunit

Open access

Muir, James, Arancibia-Carcamo, I. Lorena, MacAskill, Andrew F., Smith, Katharine R., Griffin, Lewis D., Kittler, Josef T.·2010·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1000589107PMC PMC2944765

Open this paper in CoChat — free account

Abstract

Modification of the number of GABA A receptors (GABA A Rs) clustered at inhibitory synapses can regulate inhibitory synapse strength with important implications for information processing and nervous system plasticity and pathology. Currently, however, the mechanisms that regulate the number of GABA A Rs at synapses remain poorly understood. By imaging superecliptic pHluorin tagged GABA A R subunits we show that synaptic GABA A R clusters are normally stable, but that increased neuronal activity upon glutamate receptor (GluR) activation results in their rapid and reversible dispersal. This dispersal correlates with increases in the mobility of single GABA A Rs within the clusters as determined using single-particle tracking of GABA A Rs labeled with quantum dots. GluR-dependent dispersal of GABA A R clusters requires Ca 2+ influx via NMDA receptors (NMDARs) and activation of the phosphatase calcineurin. Moreover, the dispersal of GABA A R clusters and increased mobility of individual GABA A Rs are dependent on serine 327 within the intracellular loop of the GABA A R γ2 subunit. Thus, NMDAR signaling, via calcineurin and a key GABA A R phosphorylation site, controls the stability of synaptic GABA A Rs, with important implications for activity-dependent control of synaptic inhibition and neuronal plasticity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.1000589107

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dynasore, a Cell-Permeable Inhibitor of Dynamin
Macia, E., Ehrlich, M., Massol, R., Boucrot, E., Brunner, C., & Kirchhausen, T. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.002 · Cited by 1,958
Diffusion Dynamics of Glycine Receptors Revealed by Single-Quantum Dot Tracking
Dahan, M., Lévi, S., Luccardini, C., Rostaing, P., Riveau, B., & Triller, A. (2003) · Science · doi:10.1126/science.1088525 · Cited by 1,465
Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses
MacAskill, A. F., Rinholm, J. E., Twelvetrees, A. E., Arancibia‐Cárcamo, I. L., Muir, J., Fransson, Å., Aspenström, P., Attwell, D., & Kittler, J. T. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.030 · Cited by 687
Self-citation
Locally dynamic synaptic learning rules in pyramidal neuron dendrites
Harvey, C. D., & Svoboda, K. (2007) · Nature · doi:10.1038/nature06416 · Cited by 625
Compartmentalized dendritic plasticity and input feature storage in neurons
Losonczy, A., Makara, J. K., & Magee, J. C. (2008) · Nature · doi:10.1038/nature06725 · Cited by 598
Trafficking of GABAAReceptors, Loss of Inhibition, and a Mechanism for Pharmacoresistance in Status Epilepticus
Naylor, D. E., Liu, H., & Wasterlain, C. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4944-04.2005 · Cited by 558
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Groc, L., Heine, M., Cognet, L., Brickley, K., Stephenson, F. A., Lounis, B., & Choquet, D. (2004) · Nature Neuroscience · doi:10.1038/nn1270 · Cited by 463
Activation of NMDA receptors blocks GABAergic inhibition in an in vitro model of epilepsy
Stelzer, A., Slater, N. T., & ten Bruggencate, G. (1987) · Nature · doi:10.1038/326698a0 · Cited by 388
Gating multiple signals through detailed balance of excitation and inhibition in spiking networks
Vogels, T. P., & Abbott, L. F. (2009) · Nature Neuroscience · doi:10.1038/nn.2276 · Cited by 375
Subunit-Specific Trafficking of GABAAReceptors during Status Epilepticus
Goodkin, H. P., Joshi, S., Mtchedlishvili, Z., Brar, J., & Kapur, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3426-07.2008 · Cited by 326

Show all 36 references

Sorted by citations

The Dynamic Synapse
Choquet, D., & Triller, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.013 · Cited by 560
GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses
Lüscher, B., Fuchs, T. A. E., & Kilpatrick, C. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.024 · Cited by 453
Gephyrin: a master regulator of neuronal function?
Tyagarajan, S. K., & Fritschy, J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3670 · Cited by 442
TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABA A Receptors
Pribiag, H., & Stellwagen, D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0530-13.2013 · Cited by 260
Plasticity of Inhibition
Kullmann, D. M., Moreau, A. W., Bakiri, Y., & Nicholson, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.030 · Cited by 234
Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives
Deidda, G., Bozarth, I. F., & Cancedda, L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00119 · Cited by 192
GABAA receptors and plasticity of inhibitory neurotransmission in the central nervous system
Fritschy, J., & Panzanelli, P. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12534 · Cited by 212
Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
Udakis, M., Pedrosa, V., Chamberlain, S. E. L., Clopath, C., & Mellor, J. R. (2020) · Nature Communications · doi:10.1038/s41467-020-18074-8 · Cited by 205
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP
Petrini, E. M., Ravasenga, T., Hausrat, T. J., Iurilli, G., Olcese, U., Racine, V., Sibarita, J., Jacob, T. C., Moss, S. J., Benfenati, F., et al. (2014) · Nature Communications · doi:10.1038/ncomms4921 · Cited by 196
The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines
Pathania, M., Davenport, E. C., Muir, J., Sheehan, D. F., López-Doménech, G., & Kittler, J. T. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.16 · Cited by 189
Self-citation
A pivotal role of GSK-3 in synaptic plasticity
Bradley, C. A., Peineau, S., Taghibiglou, C., Nicolas, C. S., Whitcomb, D. J., Bortolotto, Z. A., Kaang, B., Cho, K., Wang, Y. T., & Collingridge, G. L. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00013 · Cited by 202
Investigating supramolecular systems using Förster resonance energy transfer
Teunissen, A. J. P., Pérez‐Medina, C., Meijerink, A., & Mulder, W. J. M. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00278a · Cited by 174
Activity-Dependent Regulation of the K/Cl Transporter KCC2 Membrane Diffusion, Clustering, and Function in Hippocampal Neurons
Chamma, I., Heubl, M., Chevy, Q., Renner, M. L., Moutkine, I., Eugène, E., Poncer, J. C., & Lévi, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5889-12.2013 · Cited by 150
Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity
Chiu, C. Q., Barberis, A., & Higley, M. J. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0141-5 · Cited by 156
Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory
Hausrat, T. J., Muhia, M., Gerrow, K., Thomas, P., Hirdes, W., Tsukita, S., Heisler, F. F., Herich, L., Dubroqua, S., Breiden, P., et al. (2015) · Nature Communications · doi:10.1038/ncomms7872 · Cited by 138
Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling
Stephen, T., Higgs, N., Sheehan, D. F., Awabdh, S. A., López‐Doménech, G., Arancibia‐Cárcamo, I. L., & Kittler, J. T. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2068-15.2015 · Cited by 140
Self-citation
Electrophysiology of ionotropic GABA receptors
Sallard, E., Letourneur, D., & Legendre, P. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03846-2 · Cited by 143
Gephyrin, the enigmatic organizer at GABAergic synapses
Tretter, V. E., Mukherjee, J. T., Maric, H. M., Schindelin, H., Sieghart, W., & Moss, S. J. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00023 · Cited by 140
Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition
Davenport, E. C., Szulc, B. R., Drew, J., Taylor, J., Morgan, T., Higgs, N. F., López-Doménech, G., & Kittler, J. T. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.092 · Cited by 125
Self-citation
Functional regulation of GABAA receptors in nervous system pathologies
Hines, R. M., Davies, P. A., Moss, S. J., & Maguire, J. L. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.007 · Cited by 128
Bidirectional Control of Synaptic GABAAR Clustering by Glutamate and Calcium
Bannai, H., Niwa, F., Sherwood, M. W., Shrivastava, A. N., Arizono, M., Miyamoto, A., Sugiura, K., Lévi, S., Triller, A., & Mikoshiba, K. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.12.002 · Cited by 110
Regulation of GABAARs by Phosphorylation
Nakamura, Y., Darnieder, L. M., Deeb, T. Z., & Moss, S. J. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.11.008 · Cited by 118
Alterations in GABAA-Receptor Trafficking and Synaptic Dysfunction in Brain Disorders
Mele, M., Costa, R. O., & Duarte, C. B. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00077 · Cited by 108
Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity
Rosenberg, E. C., Chamberland, S., Bazelot, M., Nebet, E. R., Wang, X., McKenzie, S., Jain, S. S., Greenhill, S., Wilson, M. A., Marley, N., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.01.018 · Cited by 114
Shaping the synaptic signal: molecular mobility inside and outside the cleft
Rusakov, D. A., Savtchenko, L. P., Zheng, K., & Henley, J. M. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.03.002 · Cited by 107
Possible alterations in GABAAreceptor signaling that underlie benzodiazepine‐resistant seizures
Deeb, T. Z., Maguire, J. L., & Moss, S. J. (2012) · Epilepsia · doi:10.1111/epi.12037 · Cited by 100
DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites
Norkett, R., Modi, S., Birsa, N., Atkin, T. A., Ivankovic, D., Pathania, M., Trossbach, S. V., Korth, C., Hirst, W. D., & Kittler, J. T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.699447 · Cited by 104
Self-citation
Activity‐dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current
Saliba, R. S., Kretschmannova, K., & Moss, S. (2012) · EMBO Journal · doi:10.1038/emboj.2012.109 · Cited by 102
Localized GABAergic inhibition of dendritic Ca2+ signalling
Higley, M. J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3803 · Cited by 97
Membrane-Derived Phospholipids Control Synaptic Neurotransmission and Plasticity
García‐Morales, V., Montero, F., González‐Forero, D., Bey, G. R., Gomez-Perez, L. J., Medialdea-Wandossell, M. J., Domínguez-Vías, G., García‐Verdugo, J. M., & Moreno‐López, B. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002153 · Cited by 83
An Essential Role for the Tetraspanin LHFPL4 in the Cell-Type-Specific Targeting and Clustering of Synaptic GABAA Receptors
Davenport, E. C., Pendolino, V., Kontou, G., McGee, T. P., Sheehan, D. F., López‐Doménech, G., Farrant, M., & Kittler, J. T. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.025 · Cited by 80
Self-citation
Direct binding of GABAA receptor β2 and β3 subunits to gephyrin
Kowalczyk, S., Winkelmann, A., Smolinsky, B., Förstera, B., Neundorf, I., Schwarz, G., & Meier, J. C. (2012) · European Journal of Neuroscience · doi:10.1111/ejn.12078 · Cited by 77
GABA type a receptor trafficking and the architecture of synaptic inhibition
Lorenz‐Guertin, J. M., & Jacob, T. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22536 · Cited by 75
GABAA Receptors: Post-Synaptic Co-Localization and Cross-Talk with Other Receptors
Shrivastava, A. N., Triller, A., & Sieghart, W. (2011) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2011.00007 · Cited by 73
Neuronal activity mediated regulation of glutamate transporter GLT‐1 surface diffusion in rat astrocytes in dissociated and slice cultures
Awabdh, S. A., Gupta, S., Sheehan, D. F., Muir, J., Norkett, R., Twelvetrees, A. E., Griffin, L. D., & Kittler, J. T. (2016) · Glia · doi:10.1002/glia.22997 · Cited by 68
Self-citation
Tuning GABAergic Inhibition: Gephyrin Molecular Organization and Functions
Pizzarelli, R., Griguoli, M., Zacchi, P., Petrini, E. M., Barberis, A., Cattaneo, A., & Cherubini, E. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2019.07.036 · Cited by 69
GIT1 and βPIX Are Essential for GABAA Receptor Synaptic Stability and Inhibitory Neurotransmission
Smith, K. R., Davenport, E. C., Wei, J., Li, X., Pathania, M., Vaccaro, V., Yan, Z., & Kittler, J. T. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.061 · Cited by 71
Self-citation
Role of GABAAR trafficking in the plasticity of inhibitory synapses
Mele, M., Leal, G., & Duarte, C. B. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13742 · Cited by 71
Plasticity of GABAA receptor diffusion dynamics at the axon initial segment
Muir, J., & Kittler, J. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00151 · Cited by 69
Self-citation
The Yin and Yang of GABAergic and Glutamatergic Synaptic Plasticity: Opposites in Balance by Crosstalking Mechanisms
Chapman, C. A., Nuwer, J. L., & Jacob, T. C. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.911020 · Cited by 62
Stabilization of GABAAReceptors at Endocytic Zones Is Mediated by an AP2 Binding Motif within the GABAAReceptor β3 Subunit
Smith, K. R., Muir, J., Rao, Y., Browarski, M., Gruenig, M. C., Sheehan, D. F., Haucke, V., & Kittler, J. T. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1622-11.2011 · Cited by 64
Self-citation
Diazepam-induced loss of inhibitory synapses mediated by PLCδ/ Ca2+/calcineurin signalling downstream of GABAA receptors
Nicholson, M. W., Sweeney, A., Pekle, E., Alam, S., Ali, A. B., Duchen, M. R., & Jovanovic, J. N. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0100-y · Cited by 65
Diffusion dynamics of synaptic molecules during inhibitory postsynaptic plasticity
Petrini, E. M., & Barberis, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00300 · Cited by 65
Activity-Dependent Inhibitory Synapse Scaling Is Determined by Gephyrin Phosphorylation and Subsequent Regulation of GABAAReceptor Diffusion
Battaglia, S., Renner, M. L., Russeau, M., Côme, E., Tyagarajan, S. K., & Lévi, S. (2018) · eNeuro · doi:10.1523/eneuro.0203-17.2017 · Cited by 64
Diffusion Barriers Constrain Receptors at Synapses
Renner, M. L., Schweizer, C., Bannai, H., Triller, A., & Lévi, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043032 · Cited by 58
The Biochemical Anatomy of Cortical Inhibitory Synapses
Heller, E. A., Zhang, W., Selimi, F., Earnheart, J. C., Ślimak, M. A., Santos‐Torres, J., Ibáñez-Tallon, I., Aoki, C. J., Chait, B. T., & Heintz, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039572 · Cited by 61
GABAAR isoform and subunit structural motifs determine synaptic and extrasynaptic receptor localisation
Hannan, S. B., Minère, M., Harris, J., Izquierdo, P., Thomas, P., Tench, B., & Smart, T. G. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.022 · Cited by 52
Gephyrin-Independent GABAAR Mobility and Clustering during Plasticity
Niwa, F., Bannai, H., Arizono, M., Fukatsu, K., Triller, A., & Mikoshiba, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036148 · Cited by 53
An NMDA Receptor-Dependent Mechanism Underlies Inhibitory Synapse Development
Gu, X., Zhou, L., & Lü, W. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.061 · Cited by 53
Postsynaptic plasticity of GABAergic synapses
Barberis, A. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.05.020 · Cited by 53
Regulation of GABAergic synapse development by postsynaptic membrane proteins
Lü, W., Bromley‐Coolidge, S., & Li, J. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.07.004 · Cited by 48
Spatial regulation of coordinated excitatory and inhibitory synaptic plasticity at dendritic synapses
Ravasenga, T., Ruben, M., Regio, V., Polenghi, A., Petrini, E. M., & Barberis, A. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110347 · Cited by 48
NMDA receptor-dependent function and plasticity in inhibitory circuits
Moreau, A. W., & Kullmann, D. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.004 · Cited by 44
Live Imaging of Kv7.2/7.3 Cell Surface Dynamics at the Axon Initial Segment: High Steady-State Stability and Calpain-Dependent Excitotoxic Downregulation Revealed
Benned‐Jensen, T., Christensen, R. K., Denti, F., Perrier, J., Rasmussen, H. B., & Olesen, S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2631-15.2016 · Cited by 44
Rescue of a dystrophin-like protein by exon skipping normalizes synaptic plasticity in the hippocampus of the mdx mouse
Dallérac, G. M., Perronnet, C., Chagneau, C., Leblanc-Veyrac, P., Samson-Desvignes, N., Peltékian, E., Danos, O., Garcı́a, L., Laroche, S., Billard, J., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.05.012 · Cited by 43
Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity
Eckel, R., Szulc, B. R., Walker, M. C., & Kittler, J. T. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.09.014 · Cited by 43
Self-citation
Benzodiazepine ligands rapidly influence GABAA receptor diffusion and clustering at hippocampal inhibitory synapses
Lévi, S., Roux, N. L., Eugène, E., & Poncer, J. C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.06.002 · Cited by 43
Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death
Costa, J. T., Mele, M., Baptista, M. S., Gomes, J. R., Ruscher, K., Nobre, R. J., de Almeida, L. P., Wieloch, T. W., & Duarte, C. B. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9283-2 · Cited by 42
Antidepressant mechanisms of ketamine: Focus on GABAergic inhibition
Lüscher, B., Feng, M., & Jefferson, S. J. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.03.002 · Cited by 41
GABAA receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia
Mele, M., Ribeiro, L. F., Inácio, A. R. L., Wieloch, T. W., & Duarte, C. B. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.01.019 · Cited by 42
A Human Mutation in Gabrg2 Associated with Generalized Epilepsy Alters the Membrane Dynamics of GABAA Receptors
Bouthour, W., Leroy, F., Emmanuelli, C., Carnaud, M., Dahan, M., Poncer, J. C., & Lévi, S. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr225 · Cited by 39
Extracellular Metalloproteinases in the Plasticity of Excitatory and Inhibitory Synapses
Wiera, G., & Mozrzymas, J. W. (2021) · Cells · doi:10.3390/cells10082055 · Cited by 36
Benzodiazepine-dependent stabilization of GABAA receptors at synapses
Gouzer, G., Specht, C. G., Allain, L., Shinoe, T., & Triller, A. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.10.004 · Cited by 37
Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in Caenorhabditis elegans
Huang, Y.-C., Pirri, J. K., Rayes, D., Gao, S., Mulcahy, B., Grant, J., Saheki, Y., Francis, M. M., Zhen, M., & Alkema, M. J. (2019) · eLife · doi:10.7554/elife.45905 · Cited by 37
Disrupted Cl− homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states
Deeb, T. Z., Nakamura, Y., Frost, G. D., Davies, P. A., & Moss, S. J. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12241 · Cited by 36
Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses
Field, M., Dorovykh, V., Thomas, P., & Smart, T. G. (2021) · Nature Communications · doi:10.1038/s41467-021-22420-9 · Cited by 36
Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity
Garcia, J. D., Gookin, S. E., Crosby, K. C., Schwartz, S. L., Tiemeier, E., Kennedy, M. J., Dell’Acqua, M. L., Herson, P. S., Quillinan, N., & Smith, K. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110142 · Cited by 35
Self-citation
Phosphatase inhibition prevents the activity‐dependent trafficking of GABAAreceptors during status epilepticus in the young animal
Joshi, S., Rajasekaran, K., Hawk, K. M., Brar, J., Ross, B. M., Tran, C., Chester, S. J., & Goodkin, H. P. (2015) · Epilepsia · doi:10.1111/epi.13098 · Cited by 33
Emerging Mechanisms Underlying Dynamics of GABAergic Synapses
Maffei, A., Charrier, C., Caiati, M. D., Barberis, A., Mahadevan, V., Woodin, M. A., & Tyagarajan, S. K. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1824-17.2017 · Cited by 35
Sodium Valproate Ameliorates Neuronal Apoptosis in a Kainic Acid Model of Epilepsy via Enhancing PKC-Dependent GABAAR γ2 Serine 327 Phosphorylation
Li, Q., Li, Q.-Q., Jia, J.-N., Cao, S., Wang, Z., Wang, X., Luo, C., Zhou, H., Liu, Z., & Mao, X. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2659-8 · Cited by 31
Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking
Lorenz‐Guertin, J. M., Bambino, M. J., Das, S., Weintraub, S. T., & Jacob, T. C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00163 · Cited by 31
γ2 GABAAR Trafficking and the Consequences of Human Genetic Variation
Lorenz‐Guertin, J. M., Bambino, M. J., & Jacob, T. C. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00265 · Cited by 31
Inhibitory Receptor Diffusion Dynamics
Maynard, S. A., & Triller, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00313 · Cited by 31
Mazdutide, a dual agonist targeting GLP-1R and GCGR, mitigates diabetes-associated cognitive dysfunction: mechanistic insights from multi-omics analysis
Dong, W., Bai, J., Yuan, Q., Zhang, Y., Zhang, Y., Zhang, Z., Yang, M., Li, H., Zhao, Z., & Jiang, H. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105791 · Cited by 29
In the fast lane: Receptor trafficking during status epilepticus
Naylor, D. E. (2023) · Epilepsia Open · doi:10.1002/epi4.12718 · Cited by 27
Differential regulation of synaptic and extrasynaptic α4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons
Bohnsack, J. P., Carlson, S. L., & Morrow, A. L. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.01.009 · Cited by 26
Activity-dependent development of GABAergic synapses
Oh, W. C., & Smith, K. R. (2018) · Brain Research · doi:10.1016/j.brainres.2018.11.014 · Cited by 27
Self-citation
Integrins Bidirectionally Regulate the Efficacy of Inhibitory Synaptic Transmission and Control GABAergic Plasticity
Wiera, G., Brzdąk, P., Lech, A. M., Lebida, K., Jabłońska, J., Gmerek, P., & Mozrzymas, J. W. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.1458-21.2022 · Cited by 25
GABAergic Inhibition Regulated Pain Sensitization through STEP61 Signaling in Spinal Dorsal Horn of Mice
Li, L., Shi, L., Xu, Y., Yang, X. Z., Suo, Z., & Hu, X. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000532 · Cited by 24
Labeling of neuronal receptors and transporters with quantum dots
Chang, J. C., Kovtun, O., Blakely, R., & Rosenthal, S. J. (2012) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1186 · Cited by 22
Phospho-dependent Accumulation of GABABRs at Presynaptic Terminals after NMDAR Activation
Hannan, S. B., Gerrow, K., Triller, A., & Smart, T. G. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.021 · Cited by 21
Quantum dot conjugated nanobodies for multiplex imaging of protein dynamics at synapses
Modi, S., Higgs, N., Sheehan, D. F., Griffin, L. D., & Kittler, J. T. (2018) · Nanoscale · doi:10.1039/c7nr09130c · Cited by 21
Self-citation
Regulation of GABAA Receptors Induced by the Activation of L-Type Voltage-Gated Calcium Channels
Gravielle, M. C. (2021) · Membranes · doi:10.3390/membranes11070486 · Cited by 21
Treating acute seizures with benzodiazepines: does seizure duration matter?
Naylor, D. E. (2014) · Epileptic Disorders · doi:10.1684/epd.2014.0691 · Cited by 19
Molecular membrane dynamics: Insights into synaptic function and neuropathological disease
Bannai, H. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.07.007 · Cited by 18
Dynamics of surface neurotransmitter receptors and transporters in glial cells: Single molecule insights
Ciappelloni, S., Murphy‐Royal, C., Dupuis, J. P., Oliet, S. H. R., & Groc, L. (2017) · Cell Calcium · doi:10.1016/j.ceca.2017.08.009 · Cited by 16
Ht31 peptide inhibited inflammatory pain by blocking NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice
Wang, W.-T., Pan, G.-Q., Zhang, Z., Suo, Z., Yang, X. Z., & Hu, X. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.09.031 · Cited by 16
A versatile optical tool for studying synaptic GABAA receptor trafficking
Lorenz‐Guertin, J. M., Wilcox, M. R., Zhang, M., Larsen, M. B., Pilli, J., Schmidt, B. F., Bruchez, M. P., Johnson, J. W., Waggoner, A. S., Watkins, S. C., et al. (2017) · Journal of Cell Science · doi:10.1242/jcs.205286 · Cited by 15
γ1-Containing GABA-A Receptors Cluster at Synapses Where they Mediate Slower Synaptic Currents than γ2-Containing GABA-A Receptors
Dixon, C. L., Sah, P., Keramidas, A., Lynch, J. W., & Durisic, N. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00178 · Cited by 14
Molecular and Regulatory Mechanisms of Desensitization and Resensitization of GABAA Receptors with a Special Reference to Propofol/Barbiturate
Kang, Y., Saito, M., & Toyoda, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020563 · Cited by 15
Regulation of Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy
Tipton, A. E., & Russek, S. J. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.914374 · Cited by 16
GABA and astrocytic cholesterol determine the lipid environment of GABAAR in cultured cortical neurons
Yuan, Z., Pavel, M. A., & Hansen, S. B. (2025) · Communications Biology · doi:10.1038/s42003-025-08026-7 · Cited by 14
Imaging mGluR5 Dynamics in Astrocytes Using Quantum Dots
Arizono, M., Bannai, H., & Mikoshiba, K. (2014) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0221s66 · Cited by 14
Interferon-γ enhances neocortical synaptic inhibition by promoting membrane association and phosphorylation of GABAA receptors in a protein kinase C-dependent manner
Janach, G. M. S., Böhm, M., Döhne, N., Kim, H.-R., Rosário, M., & Strauß, U. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.01.001 · Cited by 13
Phosphorylation of neuroligin-2 by PKA regulates its cell surface abundance and synaptic stabilization
Halff, E. F., Hannan, S. B., Kwanthongdee, J., Lesept, F., Smart, T. G., & Kittler, J. T. (2022) · Science Signaling · doi:10.1126/scisignal.abg2505 · Cited by 14
Self-citation
Release your inhibitions: The cell biology of GABAergic postsynaptic plasticity
Welle, T. M., & Smith, K. R. (2024) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2024.102952 · Cited by 13
Self-citation
Conformational state-dependent regulation of GABAA receptor diffusion and subsynaptic domains
Merlaud, Z., Marques, X., Russeau, M., Saade, U., Tostain, M., Moutkine, I., Gielen, M. C., Corringer, P., & Lévi, S. (2022) · iScience · doi:10.1016/j.isci.2022.105467 · Cited by 13
Fast Regulation of GABAAR Diffusion Dynamics by Nogo-A Signaling
Fricke, S., Metzdorf, K., Ohm, M., Haak, S., Heine, M., Körte, M., & Zagrebelsky, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.015 · Cited by 13
Aberrant expression of S-SCAM causes the loss of GABAergic synapses in hippocampal neurons
Shin, S.-M., Skaar, S., Danielson, E. W., & Lee, S. H. (2020) · Scientific Reports · doi:10.1038/s41598-019-57053-y · Cited by 14
The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses
Schmerl, B., Gimber, N., Kuropka, B., Stumpf, A., Rentsch, J., Kunde, S., von Sivers, J., Ewers, H., Schmitz, D., Freund, C., et al. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001503 · Cited by 15

Authors: Muir, J., Arancibia-Carcamo, I. L., MacAskill, A. F., Smith, K. R., Griffin, L. D., & Kittler, J. T.
Affiliations: University College London (GB)
Department of Neuroscience, Physiology, and Pharmacology,
ORCID: MacAskill, Andrew F.
Smith, Katharine R.
Griffin, Lewis D.
Kittler, Josef T.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2010-09-07
Volume: 107
Issue: 38
Pages: 16679-16684
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1000589107
PMC: PMC2944765
OpenAlex: W2090585744
Cited by: 158
References: 36
Citations by year: 2026: 7 · 2025: 14 · 2024: 8 · 2023: 5 · 2022: 13 · 2021: 7 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 26 · 2013: 5 · 2012: 14
FWCI: 3.49
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: NMDA receptor, GABAA receptor, gamma2 subunit, receptor clustering, receptor lateral mobility, inhibitory synapses, synaptic inhibition, calcineurin, calcium influx, glutamate receptor activation, activity-dependent synaptic plasticity, receptor phosphorylation, single-particle tracking
MeSH terms: Animals, Cells, Cultured, Neuronal Plasticity, Neurons, Receptors, GABA-A, Recombinant Fusion Proteins, Serine, Synapses, Transfection, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Mutagenesis, Site-Directed, Glutamic Acid, Calcineurin, Amino Acid Substitution, Calcium Signaling, Multiprotein Complexes, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NMDA receptors regulate GABA A receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the γ2 subunit

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks