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Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes

Hammer, M. F., Redd, A. J., Wood, E. T., Bonner, M. R., Jarjanazi, H., Karafet, T., Santachiara-Benerecetti, S., Oppenheim, A., Jobling, M. A., Jenkins, T., Ostrer, H., Bonné-Tamir, B.·2000·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.100115997
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Abstract

Haplotypes constructed from Y-chromosome markers were used to trace the paternal origins of the Jewish Diaspora. A set of 18 biallelic polymorphisms was genotyped in 1,371 males from 29 populations, including 7 Jewish (Ashkenazi, Roman, North African, Kurdish, Near Eastern, Yemenite, and Ethiopian) and 16 non-Jewish groups from similar geographic locations. The Jewish populations were characterized by a diverse set of 13 haplotypes that were also present in non-Jewish populations from Africa, Asia, and Europe. A series of analyses was performed to address whether modern Jewish Y-chromosome diversity derives mainly from a common Middle Eastern source population or from admixture with neighboring non-Jewish populations during and after the Diaspora. Despite their long-term residence in different countries and isolation from one another, most Jewish populations were not significantly different from one another at the genetic level. Admixture estimates suggested low levels of European Y-chromosome gene flow into Ashkenazi and Roman Jewish communities. A multidimensional scaling plot placed six of the seven Jewish populations in a relatively tight cluster that was interspersed with Middle Eastern non-Jewish populations, including Palestinians and Syrians. Pairwise differentiation tests further indicated that these Jewish and Middle Eastern non-Jewish populations were not statistically different. The results support the hypothesis that the paternal gene pools of Jewish communities from Europe, North Africa, and the Middle East descended from a common Middle Eastern ancestral population, and suggest that most Jewish communities have remained relatively isolated from neighboring non-Jewish communities during and after the Diaspora.

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Metadata

Authors
Hammer, M. F., Redd, A. J., Wood, E. T., Bonner, M. R., Jarjanazi, H., Karafet, T., Santachiara-Benerecetti, S., Oppenheim, A., Jobling, M. A., Jenkins, T., Ostrer, H., & Bonné-Tamir, B.
Affiliations
Laboratory of Molecular Systematics and Evolution, University of Arizona, Tucson, AZ 85721; Department of Genetics, Università degli Studi di Pavia, Pavia 27100, Italy; Hadassah Medical School, Hebrew University of Jerusalem, Jerusalem 91120, Israel; Department of Genetics, University of Leicester, Leicester LE1 7RH, England; SAMIR, University of Witwatersrand, Johannesburg 2000, South Africa; Department of Pediatrics, New York University Medical Center, New York, NY 10016; and Department of Human...
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2000-05-09
Volume
97
Issue
12
Pages
6769-6774
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.100115997
Cited by
204
References
0
Language
en

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CoChat. (2026). Citation check: Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes. https://app.cochat.ai/papers/10.1073/pnas.100115997
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Hammer, M. F., Redd, A. J., Wood, E. T., Bonner, M. R., Jarjanazi, H., Karafet, T., Santachiara-Benerecetti, S., Oppenheim, A., Jobling, M. A., Jenkins, T., Ostrer, H., & Bonné-Tamir, B. (2000). Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.100115997