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Cited by 135Pregnancy and preeclampsia studiesNeurological Complications and SyndromesMaternal Mental Health During Pregnancy and Postpartum

Risk factors for pre‐eclampsia in nulliparous and parous women: the Jerusalem Perinatal Study

Funai, E. F., Paltiel, O. B., Malaspina, D., Friedlander, Y., Deutsch, L., Harlap, S.·2005·Paediatric and Perinatal Epidemiology
DOI 10.1111/j.1365-3016.2004.00623.x
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Abstract

Summary: Pre‐eclampsia has been described as a ‘disease of first pregnancies’ and many believe that its occurrence in a later pregnancy signals a fundamentally different entity. We sought to compare risk factors in first and subsequent pregnancies. We studied 1319 cases of pre‐eclampsia recorded in a historical cohort of 82 436 deliveries in Jerusalem in 1964–76. Logistic regression was used to control for covariates. The adjusted odds ratio (OR) for pre‐eclampsia in first births was 2.58 (95% confidence interval[CI] 2.23, 2.97), compared with all later birth order groups, between which there were no detectable differences in risk. Other risk factors included increasing maternal age, diabetes (OR 5.64, 95% CI 4.33, 7.35), multiple gestations (OR 3.38, 95% CI 2.54, 4.49), fetal haemolytic disease (OR 2.24, 95% CI 1.43, 3.50) and lower maternal education. The risk of pre‐eclampsia was not associated with the mother's employment outside the home and did not differ between immigrants vs. Israeli‐born mothers or between groups of women whose fathers had been born in Western Asia, North Africa or Europe. Effects of each risk factor were similar within first and subsequent births. These results lend no support to the hypothesis that there is a fundamental difference between pre‐eclampsia in a first pregnancy compared with that occurring in a later pregnancy; conclusions may be moderated, however, by the knowledge that the incidence of pre‐eclampsia was low in this historical cohort.

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Authors
Funai, E. F., Paltiel, O. B., Malaspina, D., Friedlander, Y., Deutsch, L., & Harlap, S.
Affiliations
  • Yale University (US)
  • Hebrew University of Jerusalem (IL)
  • New York State Psychiatric Institute (US)
  • Columbia University (US)
Corresponding author
Funai, E. F.
ORCID
Venue
Paediatric and Perinatal Epidemiology
Publisher
Wiley
Published
2005-01
Volume
19
Issue
1
Pages
59-68
ISSN
  • 0269-5022 (ISSN-L)
  • 1365-3016
DOI
10.1111/j.1365-3016.2004.00623.x
OpenAlex
W2028863648
Cited by
135
References
42
Citations by year
2024: 5 · 2023: 3 · 2022: 1 · 2021: 12 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 58 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
5.65
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 20 d)
Locations
  • Paediatric and Perinatal Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (R01CA080197, R01 CA80197-03)
  • National Center for Research Resources (M01RR000125, M01 RR-00125, K23RR015536, 1 K23 RR15536-03)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
preeclampsia, risk factors, nulliparous women, parous women, birth order, maternal age, diabetes in pregnancy, multiple pregnancy, maternal education, maternal employment, immigrant mothers
MeSH terms
Adolescent, Adult, Birth Order, Diabetes Mellitus, Type 1, Educational Status, Epidemiologic Methods, Female, Humans, Israel, Maternal Age, Middle Aged, Parity, Pre-Eclampsia, Pregnancy, Pregnancy in Diabetics, Socioeconomic Factors

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