The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Coordination of Rab8 and Rab11 in primary ciliogenesis
Open accessAbstract
Primary cilia are microtubule-based membrane projections located at the surface of many cells. Defects in primary cilia formation have been implicated in a number of genetic disorders, such as Bardet-Biedl Syndrome and Polycystic Kidney Disease. Recent studies have demonstrated that polarized vesicular transport involving Rab8 and its guanine nucleotide-exchange factor Rabin8 is essential for primary ciliogenesis. Here we report that Rabin8 is a direct downstream effector of Rab11, which functions in membrane trafficking from the trans-Golgi network and recycling endosomes. Rab11, in its GTP-bound form, interacts with Rabin8 and kinetically stimulates the guanine nucleotide-exchange activity of Rabin8 toward Rab8. Rab11 is enriched at the base of the primary cilia and inhibition of Rab11 function by a dominant-negative mutant or RNA interference blocks primary ciliogenesis. Our results suggest that Rab GTPases coordinate with each other in the regulation of vesicular trafficking during primary ciliogenesis.
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Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,547
Nachury, M. V., Loktev, A. V., Zhang, Q., Westlake, C. J., Peränen, J., Merdes, A., Slusarski, D. C., Scheller, R. H., Bazan, J. F., Sheffield, V. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.053 · Cited by 1,384
Self-citationOverview of Structure and Function of Mammalian Cilia
Satir, P., & Christensen, S. T. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.040705.141236 · Cited by 1,142 · cited 2×
“P cilia are centriole-derived, microtubule-based membrane projections at the surface of many cells (1).”
BackgroundHEF1-Dependent Aurora A Activation Induces Disassembly of the Primary Cilium
Pugacheva, E. N., Jablonski, S. A., Hartman, T. R., Henske, E. P., & Golemis, E. A. (2007) · Cell · doi:10.1016/j.cell.2007.04.035 · Cited by 890
Cited by
Genes and molecular pathways underpinning ciliopathies
Reiter, J. F., & Leroux, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.60 · Cited by 1,588
Steger, M., Diez, F., Dhekne, H. S., Lis, P., Nirujogi, R. S., Karayel, O., Tonelli, F., Martinez, T. N., Lorentzen, E., Pfeffer, S. R., et al. (2017) · eLife · doi:10.7554/elife.31012 · Cited by 482
Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors
Yoshimura, S.-I., Gerondopoulos, A., Linford, A., Rigden, D. J., & Barr, F. A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201008051 · Cited by 317
Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition
Garcia-Gonzalo, F. R., & Reiter, J. F. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028134 · Cited by 290
Phosphoinositides in Control of Membrane Dynamics
Schink, K. O., Tan, K.-W., & Stenmark, H. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125349 · Cited by 283
Metadata
- Authors
- Knödler, A., Feng, S., Zhang, J., Zhang, X., Das, A., Peränen, J., & Guo, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-03-22
- Volume
- 107
- Issue
- 14
- Pages
- 6346-6351
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2145676689
- Cited by
- 483
- References
- 4
- FWCI
- 19.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Knödler, A., Feng, S., Zhang, J., Zhang, X., Das, A., Peränen, J., & Guo, W. (2010). Coordination of Rab8 and Rab11 in primary ciliogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1002401107
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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