THE SYNAPTIC VESICLE CYCLE

Short-Term Synaptic Plasticity

Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068 · see citing works

SNAP receptors implicated in vesicle targeting and fusion

Söllner, T. H., Whiteheart, S. W., Brunner, M., Erdjument‐Bromage, H., Geromanos, S. J., Tempst, P., & Rothman, J. E. (1993) · Nature · doi:10.1038/362318a0 · Cited by 3,239 · see citing works

EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION

Heuser, J. E., & Reese, T. S. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.57.2.315 · Cited by 2,147 · see citing works

The synaptic vesicle cycle: a cascade of protein–protein interactions

Südhof, T. (1995) · Nature · doi:10.1038/375645a0 · Cited by 2,002 · see citing works

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C. (1994) · Cell · doi:10.1016/0092-8674(94)90556-8 · Cited by 1,483 · see citing works

Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion

Verhage, M., Maia, A. S., Plomp, J. J., Brussaard, A. B., Heeroma, J. H., Vermeer, H., Toonen, R. F. G., Hammer, R. E., van den Berg, T. K., Berg, et al. (2000) · Science · doi:10.1126/science.287.5454.864 · Cited by 1,431 · see citing works

Membrane Fusion

Jahn, R., Lang, T., & Südhof, T. C. (2003) · Cell · doi:10.1016/s0092-8674(03)00112-0 · Cited by 1,331 · see citing works

Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones

Bennett, M. K., Calakos, N., & Scheller, R. H. (1992) · Science · doi:10.1126/science.1321498 · Cited by 1,263 · see citing works

SNARE-mediated membrane fusion

Chen, Y. A., & Scheller, R. H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052017 · Cited by 1,133 · see citing works

Definition of the readily releasable pool of vesicles at hippocampal synapses.

Rosenmund, C., & Stevens, C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80146-4 · Cited by 1,084 · see citing works

Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation [published erratum appears in J Neurosci 1992 Aug;12(8):following table of contents]

Harris, K. M., Jensen, F. E., & Tsao, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02685.1992 · Cited by 990 · see citing works

Synaptotagmin I functions as a calcium regulator of release probability

Fernández-Chacón, R., Königstorfer, A., Gerber, S. H., García, J., Matos, M. F., Stevens, C. F., Brose, N., Rizo, J., Rosenmund, C., & Südhof, T. C. (2001) · Nature · doi:10.1038/35065004 · Cited by 961 · see citing works

Identification and characterization of the vesicular GABA transporter

McIntire, S. L., Reimer, R. J., Schuske, K. R., Edwards, R. H., & Jørgensen, E. M. (1997) · Nature · doi:10.1038/39908 · Cited by 867 · see citing works

Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons

Takamori, S., Rhee, J. S., Rosenmund, C., & Jahn, R. (2000) · Nature · doi:10.1038/35025070 · Cited by 862 · see citing works

Contrasting properties of two forms of long-term potentiation in the hippocampus

Nicoll, R., & Malenka, R. (1995) · Nature · doi:10.1038/377115a0 · Cited by 854 · see citing works

TURNOVER OF TRANSMITTER AND SYNAPTIC VESICLES AT THE FROG NEUROMUSCULAR JUNCTION

Ceccarelli, B., Hurlbut, W. P., & Mauro, A. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.57.2.499 · Cited by 837 · see citing works

Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

Perin, M. S., Fried, V. A., Mignery, G. A., Jahn, R., & Südhof, T. C. (1990) · Nature · doi:10.1038/345260a0 · Cited by 813 · see citing works

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

Augustin, I., Rosenmund, C., Südhof, T. C., & Brose, N. (1999) · Nature · doi:10.1038/22768 · Cited by 787 · see citing works

Intracellular calcium dependence of transmitter release rates at a fast central synapse

Schneggenburger, R., & Neher, E. (2000) · Nature · doi:10.1038/35022702 · Cited by 785 · see citing works

A conformational switch in syntaxin during exocytosis: role of munc18

Dulubova, I., Sugita, S., Hill, S., Hosaka, M., Fernández, I., Südhof, T., & Rizo, J. (1999) · EMBO Journal · doi:10.1093/emboj/18.16.4372 · Cited by 772 · see citing works

Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin

Hata, Y., Slaughter, C., & Südhof, T. (1993) · Nature · doi:10.1038/366347a0 · Cited by 751 · see citing works

Essential functions of synapsins I and II in synaptic vesicle regulation

Rosahl, T. W., Spillane, D., Missler, M., Herz, J., Selig, D. K., Wolff, J. R., Hammer, R. E., Malenka, R. C., & Südhof, T. C. (1995) · Nature · doi:10.1038/375488a0 · Cited by 719 · see citing works

The release of neural transmitter substances

Hubbard, J. I. (1970) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(70)90283-x · Cited by 718 · see citing works

Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells.

Buckley, K. M., & Kelly, R. B. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.100.4.1284 · Cited by 713 · see citing works

Beyond parallel fiber LTD: the diversity of synaptic and non-synaptic plasticity in the cerebellum

Hansel, C., Linden, D. J., & D'Angelo, E. (2001) · Nature Neuroscience · doi:10.1038/87419 · Cited by 694 · see citing works

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

Wang, Y., Okamoto, M., Schmitz, F., Hofmann, K., & Südhof, T. C. (1997) · Nature · doi:10.1038/41580 · Cited by 684 · see citing works

SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice

Schoch, S., Deák, F., Königstorfer, A., Mozhayeva, M. G., Sara, Y., Südhof, T. C., & Kavalali, E. T. (2001) · Science · doi:10.1126/science.1064335 · Cited by 664 · see citing works

A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons

Gras, C., Herzog, E., Bellenchi, G. C., Bernard, V., Ravassard, P., Pohl, M., Gasnier, B., Giros, B., & El Mestikawy, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05442.2002 · Cited by 639 · see citing works

Calcium influx and transmitter release in a fast CNS synapse

Borst, J. G., & Sakmann, B. J. (1996) · Nature · doi:10.1038/383431a0 · Cited by 637 · see citing works

Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP

Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A., & Nicoll, R. A. (1994) · Science · doi:10.1126/science.7916482 · Cited by 618 · see citing works

Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

Li, C., Ullrich, B., Zhang, J. Z., Anderson, R. G. W., Brose, N., & Südhof, T. C. (1995) · Nature · doi:10.1038/375594a0 · Cited by 599 · see citing works

A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter

Liu, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90425-c · Cited by 589 · see citing works

RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone

Schoch, S., Castillo, P. E., Jo, T., Mukherjee, K., Geppert, M., Wang, Y., Schmitz, F., Malenka, R. C., & Südhof, T. C. (2002) · Nature · doi:10.1038/415321a · Cited by 579 · see citing works

The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate

Fremeau, R. T., Burman, J. L., Qureshi, T., Tran, C. H., Proctor, J. M., Johnson, J., Zhang, H., Sulzer, D. L., Copenhagen, D. R., Storm‐Mathisen, J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222546799 · Cited by 568 · see citing works

Presynaptic Specificity of Endocannabinoid Signaling in the Hippocampus

Wilson, R. I., Kunos, G., & Nicoll, R. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00372-5 · Cited by 543 · see citing works

Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis

Washbourne, P., Thompson, P. M., Carta, M., da Costa, E. T., Mathews, J. R., López‐Bendito, G., Molnár, Z., Bêcher, M. W., Valenzuela, C. F., Partridge, L. D., et al. (2001) · Nature Neuroscience · doi:10.1038/nn783 · Cited by 535 · see citing works

Synapsins: Mosaics of Shared and Individual Domains in a Family of Synaptic Vesicle Phosphoproteins

Südhof, T. C., Czernik, A. J., Kao, H., Takei, K., Johnston, P. A., Horiuchi, A., Kanazir, S., Wagner, M. A., Perin, M. S., Camilli, P. V. D., et al. (1989) · Science · doi:10.1126/science.2506642 · Cited by 533 · see citing works

Distinct pools of synaptic vesicles in neurotransmitter release

Pieribone, V. A., Shupliakov, O., Brodin, L., Hilfiker, S., Czernik, A. J., & Greengard, P. (1995) · Nature · doi:10.1038/375493a0 · Cited by 532 · see citing works

Two components of transmitter release at a central synapse.

Goda, Y., & Stevens, C. F. (1994) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.91.26.12942 · Cited by 529 · see citing works

Accessory factors in clathrin-dependent synaptic vesicle endocytosis

Slepnev, V. I., & Camilli, P. V. D. (2000) · Nature reviews. Neuroscience · doi:10.1038/35044540 · Cited by 517 · see citing works

Morphological correlates of functionally defined synaptic vesicle populations

Schikorski, T., & Stevens, C. F. (2001) · Nature Neuroscience · doi:10.1038/86042 · Cited by 516 · see citing works

Calcium Sensitivity of Glutamate Release in a Calyx-Type Terminal

Bollmann, J. H., Sakmann, B. J., & Borst, J. G. G. (2000) · Science · doi:10.1126/science.289.5481.953 · Cited by 507 · see citing works

Synaptotagmins: Why So Many?*

Südhof, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100052200 · Cited by 503 · see citing works

Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release

Reim, K., Mansour, M., Varoqueaux, F., McMahon, H. T., Südhof, T. C., Brose, N., & Rosenmund, C. (2001) · Cell · doi:10.1016/s0092-8674(01)00192-1 · Cited by 500 · see citing works

Complexins: cytosolic proteins that regulate SNAP receptor function.

McMahon, H., Missler, M., Li, C., & Südhof, T. (1995) · Cell · doi:10.1016/0092-8674(95)90239-2 · Cited by 497 · see citing works

cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase

Huang, Y.-Y., Li, X.-C., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90401-4 · Cited by 490 · see citing works

Expression cloning of a reserpine-sensitive vesicular monoamine transporter.

Erickson, J. D., Eiden, L. E., & Hoffman, B. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.10993 · Cited by 488 · see citing works

Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals

Dieck, S., Sanmartí-Vila, L., Langnaese, K., Richter, K., Kindler, S., Soyke, A., Wex, H., Smalla, K.-H., Kämpf, U., Fränzer, J.-T., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.2.499 · Cited by 482 · see citing works

The role of Rab3A in neurotransmitter release

Geppert, M., Bolshakov, V., Siegelbaum, S., Takei, K., Camilli, P. D., Hammer, R., & Südhof, T. (1994) · Nature · doi:10.1038/369493a0 · Cited by 481 · see citing works

Three modes of synaptic vesicular recycling revealed by single-vesicle imaging

Gandhi, S., & Stevens, C. F. (2003) · Nature · doi:10.1038/nature01677 · Cited by 457 · see citing works

Origin of variability in quantal size in cultured hippocampal neurons and hippocampal slices.

Bekkers, J. M., Richerson, G. B., & Stevens, C. F. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5359 · Cited by 455 · see citing works

Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.

Edelmann, L., Hanson, P. I., Chapman, E. R., & Jahn, R. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb06995.x · Cited by 453 · see citing works

Three-Dimensional Structure of the Complexin/SNARE Complex

Chen, X., Tomchick, D. R., Kovrigin, E., Araç, D., Machius, M., Südhof, T. C., & Rizo, J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00583-4 · Cited by 451 · see citing works

Timing of neurotransmission at fast synapses in the mammalian brain

Sabatini, B. L., & Regehr, W. G. (1996) · Nature · doi:10.1038/384170a0 · Cited by 442 · see citing works

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis

von Mollard, G. F., Südhof, T. C., & Jahn, R. (1991) · Nature · doi:10.1038/349079a0 · Cited by 442 · see citing works

Differential expression of synaptic vesicle protein 2 (SV2) isoforms

Bajjalieh, S., Frantz, G., Weimann, J., McConnell, S., & Scheller, R. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05223.1994 · Cited by 440 · see citing works

Cyclic AMP Mediates a Presynaptic Form of LTP at Cerebellar Parallel Fiber Synapses

Salin, P. A., Malenka, R. C., & Nicoll, R. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80099-9 · Cited by 439 · see citing works

Currents through the fusion pore that forms during exocytosis of a secretory vesicle

Breckenridge, L. J., & Almers, W. (1987) · Nature · doi:10.1038/328814a0 · Cited by 432 · see citing works

Pre‐ and postsynaptic whole‐cell recordings in the medial nucleus of the trapezoid body of the rat.

Borst, J. G. G., Helmchen, F., & Sakmann, B. J. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp021095 · Cited by 432 · see citing works

Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming

Betz, A., Thakur, P., Junge, H. J., Ashery, U., Rhee, J.-S., Scheuss, V., Rosenmund, C., Rettig, J., & Brose, N. (2001) · Neuron · doi:10.1016/s0896-6273(01)00272-0 · Cited by 425 · see citing works

The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion

Geppert, M., Goda, Y., Stevens, C., & Südhof, T. (1997) · Nature · doi:10.1038/42954 · Cited by 422 · see citing works

Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release

Wucherpfennig, T., Wilsch‐Bräuninger, M., & González‐Gaitán, M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211087 · Cited by 422 · see citing works

Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)

Crowder, K. M., Gunther, J. M., Jones, T. A., Hale, B. D., Zhang, H. Z., Peterson, M. R., Scheller, R. H., Chavkin, C., & Bajjalieh, S. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15268 · Cited by 415 · see citing works

Mammalian Homologues of Caenorhabditis elegans unc-13 Gene Define Novel Family of C2-domain Proteins

Brose, N., Hofmann, K., Hata, Y., & Südhof, T. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.42.25273 · Cited by 412 · see citing works

Molecular Cloning and Functional Identification of Mouse Vesicular Glutamate Transporter 3 and Its Expression in Subsets of Novel Excitatory Neurons

Schäfer, M. K.-H., Varoqui, H., Defamie, N., Weihe, E., & Erickson, J. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206738200 · Cited by 410 · see citing works

Munc18-1 Promotes Large Dense-Core Vesicle Docking

Voets, T., Toonen, R. F., Brian, E. C., de Wit, H., Moser, T., Rettig, J., Südhof, T. C., Neher, E., & Verhage, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00391-9 · Cited by 396 · see citing works

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin

Shirataki, H., Kaibuchi, K., Sakoda, T., Kishida, S., Yamaguchi, T., Wada, K., Miyazaki, M., & Takai, Y. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2061-2068.1993 · Cited by 393 · see citing works

Optimizing Synaptic Architecture and Efficiency for High-Frequency Transmission

Taschenberger, H., Leão, R. M., Rowland, K. C., Spirou, G. A., & von Gersdorff, H. (2002) · Neuron · doi:10.1016/s0896-6273(02)01137-6 · Cited by 389 · see citing works

RIM1α is required for presynaptic long-term potentiation

Castillo, P. E., Schoch, S., Schmitz, F., Südhof, T. C., & Malenka, R. C. (2002) · Nature · doi:10.1038/415327a · Cited by 389 · see citing works

Short-term plasticity at the calyx of held

von Gersdorff, H., & Borst, J. G. G. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn705 · Cited by 388 · see citing works

The architecture of active zone material at the frog's neuromuscular junction

Harlow, M. L., Ress, D., Stoschek, A., Marshall, R. M., & McMahan, U. J. (2001) · Nature · doi:10.1038/35054000 · Cited by 388 · see citing works

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine.

Fernández, I., Araç, D., Ubach, J., Gerber, S. H., Shin, O., Gao, Y., Anderson, R. G. W., Südhof, T., & Rizo, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00548-7 · Cited by 387 · see citing works

Rabenosyn-5, a Novel Rab5 Effector, Is Complexed with Hvps45 and Recruited to Endosomes through a Fyve Finger Domain

Nielsen, E., Christoforidis, S., Uttenweiler‐Joseph, S., Miączyńska, M., Dewitte, F., Wilm, M. S., Hoflack, B., & Zerial, M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.601 · Cited by 383 · see citing works

The Caenorhabditis elegans unc-17 Gene: a Putative Vesicular Acetylcholine Transporter

Alfonso, A., Grundahl, K. M., Duerr, J. S., Han, H. P., & Rand, J. B. (1993) · Science · doi:10.1126/science.8342028 · Cited by 378 · see citing works

SV2A and SV2B Function as Redundant Ca2+ Regulators in Neurotransmitter Release

Janz, R., Goda, Y., Geppert, M., Missler, M., & Südhof, T. C. (1999) · Neuron · doi:10.1016/s0896-6273(00)81046-6 · Cited by 366 · see citing works

Three-Dimensional Reconstruction of a Calyx of Held and Its Postsynaptic Principal Neuron in the Medial Nucleus of the Trapezoid Body

Sätzler, K., Söhl, L. F., Bollmann, J. H., Borst, J. G. G., Frotscher, M., Sakmann, B. J., & Lübke, J. H. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10567.2002 · Cited by 364 · see citing works

Ca2+ Regulates the Interaction between Synaptotagmin and Syntaxin 1 (*)

Chapman, E., Hanson, P., An, S. J., & Jahn, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23667 · Cited by 363 · see citing works

Glutamate uptake by brain synaptic vesicles. Energy dependence of transport and functional reconstitution in proteoliposomes.

Maycox, P. R., Deckwerth, T. L., Hell, J. W., & Jahn, R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37605-7 · Cited by 361 · see citing works

Vesicle pools and short-term synaptic depression: lessons from a large synapse

Schneggenburger, R., Sakaba, T., & Neher, E. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02139-2 · Cited by 361 · see citing works

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

Castillo, P. E., Janz, R., Sdhof, T. C., Tzounopoulos, T., Malenka, R. C., & Nicoll, R. A. (1997) · Nature · doi:10.1038/41574 · Cited by 356 · see citing works

The kinetics of transmitter release at the frog neuromuscular junction

Barrett, E. F., & Stevens, C. F. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp010054 · Cited by 356 · see citing works

Identification of Synaptophysin as a Hexameric Channel Protein of the Synaptic Vesicle Membrane

Thomas, L., Hartung, K., Langosch, D., Rehm, H., Bamberg, E., Franke, W. W., & Betz, H. (1988) · Science · doi:10.1126/science.2461586 · Cited by 354 · see citing works

Two Endocytic Recycling Routes Selectively Fill Two Vesicle Pools in Frog Motor Nerve Terminals

Richards, D. A., Guatimosim, C., & Betz, W. J. (2000) · Neuron · doi:10.1016/s0896-6273(00)00065-9 · Cited by 353 · see citing works

Impairment of synaptic vesicle clustering and of synaptic transmission, and increased seizure propensity, in synapsin I-deficient mice.

Li, L., Chin, L., Shupliakov, O., Brodin, L., Sihra, T., Hvalby, O., Jensen, V., Zheng, D., McNamara, J. O., & Greengard, P. (1995) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.92.20.9235 · Cited by 351 · see citing works

Rapid Reuse of Readily Releasable Pool Vesicles at Hippocampal Synapses

Pyle, J. L., Kavalali, E. T., Piedras-Renterı́a, E. S., & Tsien, R. W. (2000) · Neuron · doi:10.1016/s0896-6273(00)00098-2 · Cited by 345 · see citing works

Domain structure of synaptotagmin (p65)

Perin, M., Brose, N., Jahn, R., & Südhof, T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52480-7 · Cited by 329 · see citing works

Short-term synaptic plasticity is altered in mice lacking synapsin I

Rosahl, T. (1993) · Cell · doi:10.1016/0092-8674(93)90487-b · Cited by 328 · see citing works

Three-Dimensional Comparison of Ultrastructural Characteristics at Depressing and Facilitating Synapses onto Cerebellar Purkinje Cells

Xu‐Friedman, M. A., Harris, K. M., & Regehr, W. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06666.2001 · Cited by 313 · see citing works

Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases

Sagné, C., Mestikawy, S. E., Isambert, M., Hamon, M., Henry, J., Bruno Giros, A., & Gasnier, B. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01279-9 · Cited by 311 · see citing works

Calcium dynamics associated with a single action potential in a CNS presynaptic terminal

Helmchen, F., Borst, J. G. G., & Sakmann, B. J. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78792-7 · Cited by 306 · see citing works

Direct Interaction of the Rat unc-13 Homologue Munc13-1 with the N Terminus of Syntaxin

Betz, A., Okamoto, M., Benseler, F., & Brose, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.4.2520 · Cited by 304 · see citing works

Actin-Dependent Regulation of Neurotransmitter Release at Central Synapses

Morales, M., Colicos, M. A., & Goda, Y. (2000) · Neuron · doi:10.1016/s0896-6273(00)00064-7 · Cited by 300 · see citing works

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2‐domain?

Ubach, J., Zhang, X., Shao, X., Südhof, T., & Rizo, J. (1998) · EMBO Journal · doi:10.1093/emboj/17.14.3921 · Cited by 298 · see citing works

Synaptotagmin Modulation of Fusion Pore Kinetics in Regulated Exocytosis of Dense-Core Vesicles

Wang, C.-T., Grishanin, R., Earles, C. A., Chang, P. Y., Martin, T., Chapman, E., & Jackson, M. (2001) · Science · doi:10.1126/science.1064002 · Cited by 296 · see citing works

Cast

Ohtsuka, T., Takao‐Rikitsu, E., Inoue, E., Inoue, M., Takeuchi, M., Matsubara, K., Deguchi‐Tawarada, M., Satoh, K., Morimoto, K., Nakanishi, H., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202083 · Cited by 295 · see citing works

Liprins, a Family of LAR Transmembrane Protein-tyrosine Phosphatase-interacting Proteins

Serra‐Pages, C., Medley, Q. G., Tang, M., Hart, A. C., & Streuli, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15611 · Cited by 292 · see citing works

Tomosyn: a Syntaxin-1–Binding Protein that Forms a Novel Complex in the Neurotransmitter Release Process

Fujita, Y., Shirataki, H., Sakisaka, T., Asakura, T., Ohya, T., Kotani, H., Yokoyama, S., Nishioka, H., Matsuura, Y., Mizoguchi, A., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80472-9 · Cited by 291 · see citing works

Calcium Secretion Coupling at Calyx of Held Governed by Nonuniform Channel–Vesicle Topography

Meinrenken, C., Borst, J. G., & Sakmann, B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01648.2002 · Cited by 290 · see citing works

Calcium dynamics associated with action potentials in single nerve terminals of pyramidal cells in layer 2/3 of the young rat neocortex

Koester, H. J., & Sakmann, B. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00625.x · Cited by 288 · see citing works

Simultaneous electrical and optical measurements show that membrane fusion precedes secretory granule swelling during exocytosis of beige mouse mast cells.

Zimmerberg, J. J., Curran, M., Cohen, F., et al. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.6.1585 · Cited by 283 · see citing works

A phospho-switch controls the dynamic association of synapsins with synaptic vesicles.

Hosaka, M., Hammer, R., & Südhof, T. (1999) · Neuron · doi:10.1016/s0896-6273(00)80851-x · Cited by 283 · see citing works

Synaptotagmins form a hierarchy of exocytotic Ca2+ sensors with distinct Ca2+ affinities

Sugita, S., Shin, O., Han, W., Lao, Y., & Südhof, T. (2002) · EMBO Journal · doi:10.1093/emboj/21.3.270 · Cited by 280 · see citing works

Synaptic vesicles have two distinct recycling pathways.

Koenig, J. H., & Ikeda, K. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.3.797 · Cited by 278 · see citing works

The Synaptic VesicleCycle Revisited

Südhof, T. C. (2000) · Neuron · doi:10.1016/s0896-6273(00)00109-4 · Cited by 276 · see citing works

Regulation of reversible binding of smg p25A, a ras p21-like GTP-binding protein, to synaptic plasma membranes and vesicles by its specific regulatory protein, GDP dissociation inhibitor.

Araki, S., Kikuchi, A., Hata, Y., Isomura, M., & Takai, Y. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38260-2 · Cited by 265 · see citing works

Stages of Synapse Development Defined by Dependence on F-Actin

Zhang, W., & Benson, D. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05169.2001 · Cited by 262 · see citing works

A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones

Wang, Y., Liu, X., Biederer, T., & Südhof, T. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182532999 · Cited by 256 · see citing works

Reversal of synaptic vesicle docking at central synapses

Murthy, V. N., & Stevens, C. F. (1999) · Nature Neuroscience · doi:10.1038/9149 · Cited by 254 · see citing works

Delayed Release of Neurotransmitter from Cerebellar Granule Cells

Atluri, P. P., & Regehr, W. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08214.1998 · Cited by 250 · see citing works

Single and multiple vesicle fusion induce different rates of endocytosis at a central synapse

Sun, J., Wu, X., & Wu, L. (2002) · Nature · doi:10.1038/417555a · Cited by 248 · see citing works

Phosphorylation of RIM1α by PKA Triggers Presynaptic Long-Term Potentiation at Cerebellar Parallel Fiber Synapses

Lónárt, G., Schoch, S., Kaeser, P. S., Larkin, C. J., Südhof, T. C., & Linden, D. J. (2003) · Cell · doi:10.1016/s0092-8674(03)00727-x · Cited by 244 · see citing works

A third member of the synapsin gene family

Kao, H., Porton, B., Czernik, A. J., Feng, J., Yiu, G. C., Häring, M., Benfenati, F., & Greengard, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4667 · Cited by 244 · see citing works

The RIM/NIM Family of Neuronal C2 Domain Proteins

Wang, Y., Sugita, S., & Südhof, T. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909008199 · Cited by 243 · cited 6× · see citing works

Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis.

Sugita, S., Han, W., Butz, S., Liu, X., Fernández-Chacón, R., Lao, Y., & Südhof, T. (2001) · Neuron · doi:10.1016/s0896-6273(01)00290-2 · Cited by 241 · see citing works

The regulation of quantal size

der Kloot, W. V. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90019-w · Cited by 240 · see citing works

Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle.

Calakos, N., & Scheller, R. H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31422-9 · Cited by 239 · see citing works

Synaptotagmin II. A novel differentially distributed form of synaptotagmin

Geppert, M., Archer, B. T., & Südhof, T. C. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92733-x · Cited by 234 · see citing works

Sequential steps in clathrin-mediated synaptic vesicle endocytosis

Brodin, L., Löw, P., & Shupliakov, O. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00097-0 · Cited by 233 · see citing works

Fast Kinetics of Exocytosis Revealed by Simultaneous Measurements of Presynaptic Capacitance and Postsynaptic Currents at a Central Synapse

Sun, J., & Wu, L. (2001) · Neuron · doi:10.1016/s0896-6273(01)00271-9 · Cited by 231 · see citing works

Molecular cloning and functional characterization of human vesicular glutamate transporter 3

Takamori, S., Malherbe, P., Broger, C., & Jahn, R. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf159 · Cited by 231 · see citing works

The GTPase Rab3a negatively controls calcium‐dependent exocytosis in neuroendocrine cells.

Johannes, L., Lledo, P., Roa, M., Vincent, J., Henry, J., & Darchen, F. (1994) · EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06476.x · Cited by 229 · see citing works

Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif.

Yamaguchi, T., Dulubova, I., Min, S.-W., Chen, X., Rizo, J., & Südhof, T. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00125-9 · Cited by 223 · see citing works

Evidence for the involvement of Rab3A in Ca(2+)-dependent exocytosis from adrenal chromaffin cells.

Holz, R. W., Brondyk, W. H., Senter, R. A., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34051-6 · Cited by 221 · see citing works

Quantal Release of Serotonin

Bruns, D., Riedel, D., Klingauf, J., & Jahn, R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00097-0 · Cited by 221 · see citing works

Different domains of synaptotagmin control the choice between kiss-and-run and full fusion

Wang, C., Lu, J., Bai, J., Chang, P. Y., Martin, T. F. J., Chapman, E. R., & Jackson, M. B. (2003) · Nature · doi:10.1038/nature01857 · Cited by 219 · see citing works

Quantitative Relationship between Transmitter Release and Calcium Current at the Calyx of Held Synapse

Sakaba, T., & Neher, E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00462.2001 · Cited by 216 · see citing works

The presynaptic cytomatrix of brain synapses

Dresbach, T., Qualmann, B., Kessels, M. M., Garner, C. C., & Gundelfinger, E. D. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000781 · Cited by 216 · see citing works

SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family

Janz, R., & Südhof, T. C. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00370-x · Cited by 214 · see citing works

SV2 modulates the size of the readily releasable pool of secretory vesicles

Xu, T., & Bajjalieh, S. M. (2001) · Nature Cell Biology · doi:10.1038/35087000 · Cited by 212 · see citing works

Direct Interaction of the Rab3 Effector RIM with Ca2+Channels, SNAP-25, and Synaptotagmin

Coppola, T., Magnin, S., Perret-Menoud, V., Gattesco, S., Schiavo, G., & Regazzi, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100929200 · Cited by 211 · see citing works

Synaptic Vesicle Transporter Expression Regulates Vesicle Phenotype and Quantal Size

Pothos, E. N., Larsen, K. E., Krantz, D. E., Liu, Y., Haycock, J. W., Setlik, W., Gershon, M. D., Edwards, R. H., & Sulzer, D. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07297.2000 · Cited by 211 · see citing works

Synaptic Vesicle Pools at the Frog Neuromuscular Junction

Richards, D. A., Guatimosim, C., Rizzoli, S. O., & Betz, W. J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00405-7 · Cited by 208 · see citing works

How Tlg2p/syntaxin 16 'snares’ Vps45

Dulubova, I., Yamaguchi, T., Gao, Y., Min, S., Huryeva, I., Südhof, T. C., & Rizo, J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf381 · Cited by 204 · see citing works

Functional Specialization of Presynaptic Cav2.3 Ca2+ Channels

Dietrich, D., Kirschstein, T., Kukley, M., Pereverzev, A., von der Brelie, C., Schneider, T., & Beck, H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00430-6 · Cited by 203 · see citing works

Functional properties of multiple synaptotagmins in brain.

Ullrich, B., Li, C., Zhang, J. Z., McMahon, H., Anderson, R. G. W., Geppert, M., & Südhof, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90415-4 · Cited by 199 · see citing works

Control of Fusion Pore Dynamics During Exocytosis by Munc18

Fisher, R. J., Pevsner, J., & Burgoyne, R. D. (2001) · Science · doi:10.1126/science.291.5505.875 · Cited by 195 · see citing works

Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C.

Cai, L., Takei, K., Geppert, M., Daniell, L., Stenius, K., Chapman, E., Jahn, R., Camilli, P. D., & Südhof, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90254-2 · Cited by 194 · see citing works

Interaction of the ERC Family of RIM-binding Proteins with the Liprin-α Family of Multidomain Proteins

Ko, J., Na, M., Kim, S.-H., Lee, J.-R., & Kim, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307561200 · Cited by 185 · see citing works

Localization Versus Function of Rab3 Proteins

Schlüter, O., Khvotchev, M., Jahn, R., & Südhof, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203704200 · Cited by 184 · see citing works

Local routes revisited: the space and time dependence of the Ca2+ signal for phasic transmitter release at the rat calyx of Held

Meinrenken, C. J., Borst, J. G. G., & Sakmann, B. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.032714 · Cited by 183 · see citing works

Molecular cloning of a putative vesicular transporter for acetylcholine.

Roghani, A., Feldman, J. D., Kohan, S. A., Shirzadi, A., Gundersen, C. B., Brecha, N. C., & Edwards, R. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10620 · Cited by 180 · see citing works

The Synaptophysin–Synaptobrevin Complex: a Hallmark of Synaptic Vesicle Maturation

Becher, A., Drenckhahn, A., Pahner, I., Margittai, M., Jahn, R., & Ahnert‐Hilger, G. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01922.1999 · Cited by 178 · see citing works

Piccolo, a novel 420 kDa protein associated with the presynaptic cytomatrix.

Cases-Langhoff, C., Voss, B., Garner, A. M., APPELTAUER, U., Takei, K., Kindler, S., Veh, R. W., Camilli, P. V. D., Gundelfinger, E. D., & Garner, C. C. (1996) · PubMed · Cited by 176 · see citing works

Exocytotic fusion is activated by Rab3a peptides

Oberhauser, A. F., Monck, J. R., Balch, W. E., & Fernández, J. M. (1992) · Nature · doi:10.1038/360270a0 · Cited by 174 · see citing works

Potentiation of Developing Synapses by Postsynaptic Release of Neurotrophin-4

Wang, X.-H., & Poo, M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80964-2 · Cited by 173 · see citing works

Rabphilin Knock-Out Mice Reveal That Rabphilin Is Not Required for Rab3 Function in Regulating Neurotransmitter Release

Schlüter, O. M., Schnell, E., Verhage, M., Tzonopoulos, T., Nicoll, R. A., Janz, R., Malenka, R. C., Geppert, M., & Südhof, T. C. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05834.1999 · Cited by 172 · see citing works

Properties of synchronous and asynchronous release during pulse train depression in cultured hippocampal neurons.

Hagler, D., & Goda, Y. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2324 · Cited by 167 · see citing works

Regulation of Neurotransmitter Release by Synapsin III

Feng, J., Chi, P., Blanpied, T. A., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04372.2002 · Cited by 151 · see citing works

The R-SNARE Motif of Tomosyn Forms SNARE Core Complexes with Syntaxin 1 and SNAP-25 and Down-regulates Exocytosis

Hatsuzawa, K., Lang, T., Fasshauer, D., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305500200 · Cited by 147 · see citing works

Isoform-specific, Calcium-regulated Interaction of the Synaptic Vesicle Proteins SV2 and Synaptotagmin*

Schivell, A. E., Batchelor, R., & Bajjalieh, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27770 · Cited by 145 · see citing works

Presynaptic Long-Term Potentiation in Corticothalamic Synapses

Castro‐Alamancos, M. A., & Calcagnotto, M. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-09090.1999 · Cited by 139 · see citing works

Vesicle-associated membrane protein-2 (synaptobrevin-2) forms a complex with synaptophysin

Washbourne, P., Schiavo, G., & Montecucco, C. (1995) · Biochemical Journal · doi:10.1042/bj3050721 · Cited by 133 · see citing works

Divergent Functions of Neuronal Rab11b in Ca2+-Regulated versus Constitutive Exocytosis

Khvotchev, M. V., Ren, M., Takamori, S., Jahn, R., & Südhof, T. C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10531.2003 · Cited by 132 · see citing works

Distinct Roles of Synapsin I and Synapsin II during Neuronal Development

Ferreira, A., Chin, L.-S., Li, L., Lanier, L. M., Kosik, K. S., & Greengard, P. (1998) · Molecular Medicine · doi:10.1007/bf03401726 · Cited by 131 · see citing works

Choline metabolism in the cerebral cortex of guinea pigs. Stable-bound acetylcholine

Barker, L. A., Dowdall, M. J., & Whittaker, V. P. (1972) · Biochemical Journal · doi:10.1042/bj1301063 · Cited by 131 · see citing works

Structure/Function Analysis of Ca2+ Binding to the C2A Domain of Synaptotagmin 1

Fernández-Chacón, R., Shin, O., Königstorfer, A., Matos, M. F., Meyer, A. C., Garcia, J. M., Gerber, S. H., Rizo, J., Südhof, T., & Rosenmund, C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08438.2002 · Cited by 130 · see citing works

Electrostatic and hydrophobic interactions of synapsin I and synapsin I fragments with phospholipid bilayers

Benfenati, F., Greengard, P., Brunner, J., & Bähler, M. (1989) · Journal of Cell Biology · doi:10.1083/jcb.108.5.1851 · Cited by 130 · see citing works

Distinct Ca-dependent Properties of the First and Second C-domains of Synaptotagmin I (*)

Sugita, S., Hata, Y., & Südhof, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1262 · Cited by 128 · see citing works

Sr2+ Binding to the Ca2+ Binding Site of the Synaptotagmin 1 C2B Domain Triggers Fast Exocytosis without Stimulating SNARE Interactions

Shin, O., Rhee, J., Tang, J., Sugita, S., Rosenmund, C., & Südhof, T. C. (2003) · Neuron · doi:10.1016/s0896-6273(02)01145-5 · Cited by 128 · see citing works

Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathway.

von Mollard, G. F., Stahl, B., Walch-Solimena, C., Takei, K., Daniels, L. S., Khoklatchev, A., Camilli, P. V. D., Südhof, T. C., & Jahn, R. (1994) · PubMed · Cited by 127 · see citing works

Synapsin I is structurally similar to ATP‐utilizing enzymes

Esser, L., Wang, C.-R., Hosaka, M., Smagula, C. S., Südhof, T. C., & Deisenhofer, J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.4.977 · Cited by 126 · see citing works

Chronic Blockade of Glutamate Receptors Enhances Presynaptic Release and Downregulates the Interaction between Synaptophysin-Synaptobrevin–Vesicle-Associated Membrane Protein 2

Bacci, A., Coco, S., Pravettoni, E., Schenk, U., Armano, S., Frassoni, C., Verderio, C., Camilli, P. V. D., & Matteoli, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06588.2001 · Cited by 126 · see citing works

Examining Synaptotagmin 1 Function in Dense Core Vesicle Exocytosis under Direct Control of Ca2+

Sørensen, J. B., Fernández-Chacón, R., Südhof, T., & Neher, E. (2003) · The Journal of General Physiology · doi:10.1085/jgp.200308855 · Cited by 124 · see citing works

Heterogeneous presynaptic release probabilities: functional relevance for short-term plasticity.

Trommershäuser, J., Schneggenburger, R., Zippelius, A., & Neher, E. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74967-4 · Cited by 124 · see citing works

Complexin Regulates the Closure of the Fusion Pore during Regulated Vesicle Exocytosis

Archer, D. A., Graham, M. E., & Burgoyne, R. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200166200 · Cited by 122 · see citing works

Redistribution of synaptophysin and synapsin I during alpha-latrotoxin-induced release of neurotransmitter at the neuromuscular junction.

Tarelli, F. T., Villa, A., Valtorta, F., Camilli, P. V. D., Greengard, P., & Ceccarelli, B. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.2.449 · Cited by 122 · see citing works

Structure of the 116-kDa polypeptide of the clathrin-coated vesicle/synaptic vesicle proton pump

Perin, M. S., Fried, V. A., Stone, D. K., Xie, X., & Südhof, T. C. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67875-0 · Cited by 116 · see citing works

The SNARE Vti1a-β Is Localized to Small Synaptic Vesicles and Participates in a Novel SNARE Complex

Antonin, W., Riedel, D., & von Mollard, G. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05724.2000 · Cited by 113 · see citing works

Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins☆☆Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. AF548738 and AF548739.

Wang, Y., & Südhof, T. C. (2003) · Genomics · doi:10.1016/s0888-7543(02)00024-1 · Cited by 112 · see citing works

Comparison of Cysteine String Protein (Csp) and Mutant α-SNAP Overexpression Reveals a Role for Csp in Late Steps of Membrane Fusion in Dense-Core Granule Exocytosis in Adrenal Chromaffin Cells

Graham, M. E., & Burgoyne, R. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01281.2000 · Cited by 112 · see citing works

The synaptic vesicle cycle: exocytosis and endocytosis in Drosophila and C. elegans

Richmond, J. E., & Broadie, K. S. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00360-4 · Cited by 112 · see citing works

The SV2 Protein of Synaptic Vesicles Is a Keratan Sulfate Proteoglycan

Scranton, T. W., Iwata, M., & Carlson, S. S. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03535.x · Cited by 107 · see citing works

The multisubunit structure of synaptophysin. Relationship between disulfide bonding and homo-oligomerization.

Johnston, P. A., & Südhof, T. C. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38968-9 · Cited by 104 · see citing works

Homo- and Heterodimerization of Synapsins

Hosaka, M., & Südhof, T. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.16747 · Cited by 103 · see citing works

Cloning and expression of the vesamicol binding protein from the marine ray Torpedo

Varoqui, H., Diebler, M., Meunier, F.-M., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80592-x · Cited by 102 · see citing works

Amino acid neurotransmission: Dynamics of vesicular uptake

Fykse, E. M., & Fonnum, F. (1996) · Neurochemical Research · doi:10.1007/bf02532415 · Cited by 101 · see citing works

Synapsins I and II Are ATP-binding Proteins with Differential Ca2+ Regulation*

Hosaka, M., & Südhof, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1425 · Cited by 100 · see citing works

Amisyn, a Novel Syntaxin-binding Protein That May Regulate SNARE Complex Assembly

Scales, S. J., Hesser, B. A., Masuda, E. S., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204929200 · Cited by 98 · see citing works

Multiple aspects of Rab protein action in the secretory pathway: Focus on Rab3 and Rab6

Darchen, F. (2000) · Biochimie · doi:10.1016/s0300-9084(00)00219-4 · Cited by 95 · see citing works

Synapsin III, a Novel Synapsin with an Unusual Regulation by Ca2+

Hosaka, M., & Südhof, T. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13371 · Cited by 95 · see citing works

SVOP, an Evolutionarily Conserved Synaptic Vesicle Protein, Suggests Novel Transport Functions of Synaptic Vesicles

Janz, R., Hofmann, K., & Südhof, T. C. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09269.1998 · Cited by 94 · see citing works

rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence

Johnston, P. A., Archer, B. T., Robinson, K., Mignery, G. A., Jahn, R., & Südhof, T. C. (1991) · Neuron · doi:10.1016/0896-6273(91)90078-e · Cited by 94 · see citing works

Essential function of α-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse

Hinds, H. L., Goussakov, I. V., Nakazawa, K., Tonegawa, S., & Bolshakov, V. Y. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530202100 · Cited by 89 · see citing works

2 Synapsin I, an actin-binding protein regulating synaptic vesicle traffic in the nerve terminal

Greengard, P., Benfenati, F., & Valtorta, F. (1994) · Advances in second messenger and phosphoprotein research · doi:10.1016/s1040-7952(06)80005-4 · Cited by 83 · see citing works

Dimerization of the Synaptic Vesicle Protein Synaptobrevin (Vesicle‐Associated Membrane Protein) II Depends on Specific Residues within the Transmembrane Segment

Laage, R., & Langosch, D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00540.x · Cited by 81 · see citing works

Long-Term Potentiation of Glial Synaptic Currents in Cerebellar Culture

Linden, D. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80337-2 · Cited by 80 · see citing works

The maintenance of LTP at hippocampal mossy fiber synapses is independent of sustained presynaptic calcium

Regehr, W. G., & Tank, D. W. (1991) · Neuron · doi:10.1016/0896-6273(91)90297-d · Cited by 80 · see citing works

Structure of the Janus-faced C2B domain of rabphilin

Ubach, J., Garcia, J. M., Nittler, M., Südhof, T., & Rizo, J. (1999) · Nature Cell Biology · doi:10.1038/10076 · Cited by 72 · see citing works

Developmental Increase in Vesicular Glutamate Content Does Not Cause Saturation of AMPA Receptors at the Calyx of Held Synapse

Yamashita, T., Ishikawa, T., & Takahashi, T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03633.2003 · Cited by 72 · see citing works

Presynaptic Capacitance Measurements and Ca2+ Uncaging Reveal Submillisecond Exocytosis Kinetics and Characterize the Ca2+ Sensitivity of Vesicle Pool Depletion at a Fast CNS Synapse

Wölfel, M., & Schneggenburger, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07059.2003 · Cited by 71 · see citing works

Calcium regulation of neurotransmitter release: reliably unreliable?

Goda, Y., & Südhof, T. C. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80027-0 · Cited by 70 · see citing works

Cycling of Synaptic Vesicles: How Far? How Fast!

Galli, T., & Haucke, V. (2001) · Science s STKE · doi:10.1126/stke.2001.88.re1 · Cited by 65 · see citing works

F-Actin Is Concentrated in Nonrelease Domains at Frog Neuromuscular Junctions

Dunaevsky, A., & Connor, E. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06007.2000 · Cited by 64 · see citing works

Synaptic vesicles contain an ATP‐dependent proton pump and show ‘knob‐like’ protrusions on their surface.

Stadler, H., & Tsukita, S. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb02300.x · Cited by 62 · see citing works

Modulation of Transmitter Release by Action Potential Duration at the Hippocampal CA3-CA1 Synapse

Qian, J., & Saggau, P. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.1.288 · Cited by 62 · see citing works

Rim1 and Rabphilin-3 Bind Rab3-GTP by Composite Determinants Partially Related through N-terminal α-Helix Motifs

Wang, X., Hu, B., Zimmermann, B., & Kilimann, M. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103337200 · Cited by 59 · see citing works

Presynaptic Ca2+Entry Is Unchanged during Hippocampal Mossy Fiber Long-Term Potentiation

Kamiya, H., Umeda, K., Ozawa, S., & Manabe, T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10524.2002 · Cited by 56 · see citing works

Effects of 2-(4-Morpholinyl)-8-Phenyl-4H-1-Benzopyran-4-One on Synaptic Vesicle Cycling at the Frog Neuromuscular Junction

Rizzoli, S. O., & Betz, W. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10680.2002 · Cited by 56 · see citing works

RIM1: an edge for presynaptic plasticity.

Lonart, G. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02193-8 · Cited by 49 · see citing works

Structure, subunit function and regulation of the coated vesicle and yeast vacuolar (H+)-ATPases

Arata, Y., Nishi, T., Kawasaki-Nishi, S., et al. (2002) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(02)00257-8 · Cited by 45 · see citing works

Calcium Signaling

Clapham, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.11.028 · Cited by 4,175 · see citing works

SNAREs — engines for membrane fusion

Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635 · see citing works

Molecular anatomy of a trafficking organelle

Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.030 · Cited by 2,373 · see citing works

Neuroligins and neurexins link synaptic function to cognitive disease

Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849 · see citing works

Voltage-Gated Calcium Channels

Catterall, W. A. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003947 · Cited by 1,628 · see citing works

The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View

Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003 · see citing works

Calcium Channel Regulation and Presynaptic Plasticity

Catterall, W. A., & Few, A. P. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.005 · Cited by 647 · see citing works

Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human Brain

Evrony, G. D., Cai, X., Lee, E., Hills, L. B., Elhosary, P. C., Lehmann, H. S., Parker, J. J., Atabay, K. D., Gilmore, E. C., Poduri, A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.035 · Cited by 548 · see citing works

Lower synaptic density is associated with depression severity and network alterations

Holmes, S. E., Scheinost, D., Finnema, S. J., Naganawa, M., Davis, M. T., DellaGioia, N., Nabulsi, N., Matuskey, D., Angarita, G. A., Pietrzak, R. H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09562-7 · Cited by 484 · see citing works

Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP

Shibasaki, T., Takahashi, H., Miki, T., Sunaga, Y., Matsumura, K., Yamanaka, M., Zhang, C., Tamamoto, A., Satoh, T., Miyazaki, J.-I., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707054104 · Cited by 425 · see citing works

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease

Goetzl, E. J., Kapogiannis, D., Schwartz, J. B., Lobach, I. V., Goetzl, L., Abner, E. L., Jicha, G. A., Karydas, A. M., Boxer, A., & Miller, B. L. (2016) · The FASEB Journal · doi:10.1096/fj.201600816r · Cited by 398 · see citing works

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

Ma, C., Li, W., Xu, Y., & Rizo, J. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2047 · Cited by 363 · see citing works

Synaptotagmin-1, -2, and -9: Ca2+ Sensors for Fast Release that Specify Distinct Presynaptic Properties in Subsets of Neurons

Xu, J., Mashimo, T., & Südhof, T. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.004 · Cited by 336 · see citing works

Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan

Sigismund, S., Confalonieri, S., Ciliberto, A., Polo, S., Scita, G., & Di Fiore, P. P. (2012) · Physiological Reviews · doi:10.1152/physrev.00005.2011 · Cited by 338 · see citing works

Synapse Pathology in Psychiatric and Neurologic Disease

van Spronsen, M., & Hoogenraad, C. C. (2010) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-010-0104-8 · Cited by 345 · see citing works

Structural and synaptic plasticity in stress-related disorders

Christoffel, D. J., Golden, S. A., & Russo, S. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.044 · Cited by 334 · see citing works

Proteomic Analysis of in Vivo Phosphorylated Synaptic Proteins

Collins, M. O., Yu, L., Coba, M. P., Husi, H., Campuzano, I., Blackstock, W. P., Choudhary, J. S., & Grant, S. G. N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411220200 · Cited by 320 · see citing works

Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention

Yap, K., Lim, Z. Q., Khandelia, P., Friedman, B., & Makeyev, E. V. (2012) · Genes & Development · doi:10.1101/gad.188037.112 · Cited by 286 · see citing works

Synaptic vesicle recycling: steps and principles

Rizzoli, S. O. (2014) · The EMBO Journal · doi:10.1002/embj.201386357 · Cited by 317 · see citing works

Tunneling nanotubes: A new route for the exchange of components between animal cells

Gerdes, H.-H., Bukoreshtliev, N. V., & Barroso, J. F. V. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.03.071 · Cited by 304 · see citing works

A genomic view of the sea urchin nervous system

Burke, R. D., Angerer, L. M., Elphick, M. R., Humphrey, G. W., Yaguchi, S., Kiyama, T., Liang, S., Mu, X., Agca, C., Klein, W. H., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.007 · Cited by 293 · see citing works

Conformational switch of syntaxin-1 controls synaptic vesicle fusion

Gerber, S. H., Rah, J.-C., Min, S.-W., Liu, X., de Wit, H., Dulubova, I., Meyer, A. C., Rizo, J., Arancillo, M., Hammer, R. E., et al. (2008) · Science · doi:10.1126/science.1163174 · Cited by 294 · see citing works

RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13

Deng, L., Kaeser, P. S., Xu, W., & Südhof, T. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.005 · Cited by 287 · see citing works

Dysfunction of NMDA receptors in Alzheimer’s disease

Zhang, Y., Li, P., Feng, J., & Wu, M. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2546-5 · Cited by 282 · see citing works

Synaptic Vesicle Pools and Dynamics

Alabi, A. A., & Tsien, R. W. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013680 · Cited by 284 · see citing works

Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography

Fernández-Busnadiego, R., Zuber, B., Maurer, U. E., Cyrklaff, M., Baumeister, W., & Lučić, V. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200908082 · Cited by 267 · see citing works

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon

Altrock, W. D., tom Dieck, S., Sokolov, M., Meyer, A. C., Sigler, A., Brakebusch, C., Fässler, R., Richter, K., Boeckers, T. M., Potschka, H., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00088-6 · Cited by 258 · see citing works

Molecular Circuitry of Endocytosis at Nerve Terminals

Dittman, J., & Ryan, T. A. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113302 · Cited by 238 · see citing works

Bassoon speeds vesicle reloading at a central excitatory synapse

Hallermann, S., Fejtova, A., Schmidt, H., Weyhersmüller, A., Silver, R. A., Gundelfinger, E. D., & Eilers, J. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.026 · Cited by 223 · see citing works

SYD-2 Liprin-α organizes presynaptic active zone formation through ELKS

Dai, Y., Taru, H., Deken, S. L., Grill, B., Ackley, B., Nonet, M. L., & Jin, Y. (2006) · Nature Neuroscience · doi:10.1038/nn1808 · Cited by 218 · see citing works

Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease

Guo, L., Tian, J., & Du, H. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160702 · Cited by 211 · see citing works

Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis

Ohara-Imaizumi, M., Fujiwara, T., Nakamichi, Y., Okamura, T., Akimoto, Y., Kawai, J., Matsushima, S., Kawakami, H., Watanabe, T., Akagawa, K., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608132 · Cited by 211 · see citing works

Mechanism of neurotransmitter release coming into focus

Rizo, J. (2018) · Protein Science · doi:10.1002/pro.3445 · Cited by 210 · see citing works

Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity

Schlüter, O. M., Basu, J., Südhof, T. C., & Rosenmund, C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3553-05.2006 · Cited by 199 · see citing works

Fluid Biomarkers for Synaptic Dysfunction and Loss

Camporesi, E., Nilsson, J., Brinkmalm, A., Becker, B., Ashton, N. J., Blennow, K., & Zetterberg, H. (2020) · Biomarker Insights · doi:10.1177/1177271920950319 · Cited by 165 · see citing works

SV2 Renders Primed Synaptic Vesicles Competent for Ca²⁺-Induced Exocytosis

Chang, W.-P., & Südhof, T. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4521-08.2009 · Cited by 176 · see citing works

Synapse loss in dementias

Clare, R., King, V. G., Wirenfeldt, M., & Vinters, H. V. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22392 · Cited by 163 · see citing works

Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms

Denis, I., Potier, B., Vancassel, S., Heberden, C., & Lavialle, M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.01.007 · Cited by 150 · see citing works

Vesicle-Mediated Steroid Hormone Secretion in Drosophila melanogaster

Yamanaka, N., Marqués, G., & O’Connor, M. B. (2015) · Cell · doi:10.1016/j.cell.2015.10.022 · Cited by 147 · see citing works

Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer

Gray, N. W., Fourgeaud, L., Huang, B., Chen, J., Cao, H., Oswald, B. J., Hémar, A., & McNiven, M. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00136-2 · Cited by 143 · see citing works

Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP

Ahmad, M., Polepalli, J. S., Goswami, D., Yang, X., Kaeser-Woo, Y. J., Südhof, T. C., & Malenka, R. C. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.020 · Cited by 133 · see citing works

Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

Lu, J., Machius, M., Dulubova, I., Dai, H., Südhof, T. C., Tomchick, D. R., & Rizo, J. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040192 · Cited by 132 · see citing works

Neurotransmitter release regulated by a MALS-liprin-α presynaptic complex

Olsen, O., Moore, K. A., Fukata, M., Kazuta, T., Trinidad, J. C., Kauer, F. W., Streuli, M., Misawa, H., Burlingame, A. L., Nicoll, R. A., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200503011 · Cited by 128 · see citing works

Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load

Milnerwood, A. J., & Raymond, L. A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.142448 · Cited by 126 · see citing works

The Synaptic Vesicle Glycoprotein 2: Structure, Function, and Disease Relevance

Stout, K. A., Dunn, A. R., Hoffman, C., & Miller, G. W. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00351 · Cited by 112 · see citing works

A Gain-of-Function Mutation in Synaptotagmin-1 Reveals a Critical Role of Ca ²⁺ -Dependent Soluble <i>N</i> -Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Complex Binding in Synaptic Exocytosis

Pang, Z. P., Shin, O.-H., Meyer, A. C., Rosenmund, C., & Südhof, T. C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3804-06.2006 · Cited by 113 · see citing works

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

Xian, X., Pohlkamp, T., Durakoglugil, M. S., Wong, C. H., Beck, J. K., Lane-Donovan, C., Plattner, F., & Herz, J. (2018) · eLife · doi:10.7554/elife.40048 · Cited by 98 · see citing works

Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function

Varela-Nallar, L., Grabowski, C. P., Alfaro, I. E., Alvarez, A. R., & Inestrosa, N. C. (2009) · Neural Development · doi:10.1186/1749-8104-4-41 · Cited by 97 · see citing works

Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion

Gustavsson, N., & Han, W. (2009) · Bioscience Reports · doi:10.1042/bsr20090031 · Cited by 91 · see citing works

Scribble Interacts with β-Catenin to Localize Synaptic Vesicles to Synapses

Sun, Y., Aiga, M., Yoshida, E., Humbert, P. O., & Bamji, S. X. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1172 · Cited by 93 · see citing works

Acute Cocaine Induces Fast Activation of D1 Receptor and Progressive Deactivation of D2 Receptor Striatal Neurons:<i>In Vivo</i>Optical Microprobe [Ca²⁺]_iImaging

Luo, Z., Volkow, N. D., Heintz, N., Pan, Y., & Du, C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2369-11.2011 · Cited by 90 · see citing works

A secretagogin locus of the mammalian hypothalamus controls stress hormone release

Romanov, R. A., Alpár, A., Zhang, M., Zeisel, A., Calas, A., Landry, M., Fuszard, M., Shirran, S. L., Schnell, R., Dobolyi, Á., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201488977 · Cited by 85 · see citing works

Syntaxin-3 regulates newcomer insulin granule exocytosis and compound fusion in pancreatic beta cells

Zhu, D., Koo, E., Kwan, E., Kang, Y., Park, S., Xie, H., Sugita, S., & Gaisano, H. Y. (2013) · Diabetologia · doi:10.1007/s00125-012-2757-0 · Cited by 81 · see citing works

An Ancient Duplication of Exon 5 in the Snap25 Gene Is Required for Complex Neuronal Development/Function

Johansson, J. U., Ericsson, J., Janson, J., Beraki, S., Stanić, D., Mandic, S. A., Wikström, M. A., Hökfelt, T., Ögren, S. O., Rozell, B., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000278 · Cited by 83 · see citing works

Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning

Tsetsenis, T., Younts, T. J., Chiu, C. Q., Kaeser, P. S., Castillo, P. E., & Südhof, T. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112237108 · Cited by 81 · see citing works

Cysteine String Protein-α Prevents Activity-Dependent Degeneration in GABAergic Synapses

García-Junco-Clemente, P., Cantero, G., Gómez-Sánchez, L., Linares-Clemente, P., Martínez-López, J. A., Luján, R., & Fernández-Chacón, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0924-10.2010 · Cited by 79 · see citing works

Role for Reelin in neurotransmitter release

Hellwig, S., Hack, I., Kowalski, J., Brunne, B., Jarowyj, J., Unger, A., Bock, H. H., Junghans, D., & Frotscher, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-10.2011 · Cited by 74 · see citing works

Anxiety induced by prenatal stress is associated with suppression of hippocampal genes involved in synaptic function

Bogoch, Y., Biala, Y. N., Linial, M., & Weinstock, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04402.x · Cited by 74 · see citing works

Redundant Localization Mechanisms of RIM and ELKS in<i>Caenorhabditis elegans</i>

Deken, S. L., Vincent, R., Hadwiger, G., Liu, Q., Wang, Z.-W., & Nonet, M. L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0804-05.2005 · Cited by 72 · see citing works

Ca-Stimulated Type 8 Adenylyl Cyclase Is Required for Rapid Acquisition of Novel Spatial Information and for Working/Episodic-Like Memory

Zhang, M., Moon, C., Chan, G. C.-K., Yang, L., Zheng, F., Conti, A. C., Muglia, L., Muglia, L. J., Storm, D. R., & Wang, H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1177-08.2008 · Cited by 67 · see citing works

Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer’s disease

Eteleeb, A. M., Novotny, B. C., Tarraga, C. S., Sohn, C., Dhungel, E., Brase, L., Nallapu, A., Buss, J., Farias, F., Bergmann, K., et al. (2024) · PLOS Biology · doi:10.1371/journal.pbio.3002607 · Cited by 64 · see citing works

Ketamine regulates the presynaptic release machinery in the hippocampus

Müller, H. K., Wegener, G., Liebenberg, N., Zarate, C. A., Popoli, M., & Elfving, B. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.03.008 · Cited by 61 · see citing works

Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder

D’Souza, D. C., Radhakrishnan, R., Naganawa, M., Ganesh, S., Nabulsi, N., Najafzadeh, S., Ropchan, J., Ranganathan, M., Cortes-Briones, J., Huang, Y., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00891-4 · Cited by 55 · see citing works

Impaired neurotransmission in ether lipid-deficient nerve terminals

Brodde, A., Teigler, A., Brugger, B., Lehmann, W. D., Wieland, F., Berger, J., & Just, W. W. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds097 · Cited by 57 · see citing works

The dose makes the poison: From glutamate-mediated neurogenesis to neuronal atrophy and depression

Rubio-Casillas, A., & Fernández-Guasti, A. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0066 · Cited by 49 · see citing works

Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals

Lenkey, N., Kirizs, T., Holderith, N., Máté, Z., Szabó, G., Vizi, E. S., Hájos, N., & Nusser, Z. (2015) · Nature Communications · doi:10.1038/ncomms7557 · Cited by 45 · see citing works

Excitation–transcription coupling in sympathetic neurons and the molecular mechanism of its initiation

Ma, H., Groth, R. D., Wheeler, D. G., Barrett, C. F., & Tsien, R. W. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.02.004 · Cited by 42 · see citing works

Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil

Wu, P.-P., Cao, B.-R., Tian, F.-Y., & Gao, Z.-B. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-023-01138-2 · Cited by 35 · see citing works

Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

Zoltowska, K. M., Maesako, M., Lushnikova, I., Takeda, S., Keller, L. J., Skibo, G., Hyman, B. T., & Berezovska, O. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0159-y · Cited by 36 · see citing works

Pharmacokinetic Characterization of [¹⁸F]UCB-H PET Radiopharmaceutical in the Rat Brain

Becker, G., Warnier, C., Serrano, M. E., Bahri, M. A., Mercier, J., Lemaire, C., Salmon, E., Luxen, A., & Plenevaux, A. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00235 · Cited by 31 · see citing works

Chronic Desipramine Prevents Acute Stress-Induced Reorganization of Medial Prefrontal Cortex Architecture by Blocking Glutamate Vesicle Accumulation and Excitatory Synapse Increase

Nava, N., Treccani, G., Liebenberg, N., Chen, F., Popoli, M., Wegener, G., & Nyengaard, J. R. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu085 · Cited by 32 · see citing works

Long-Term Memory Stabilized by Noise-Induced Rehearsal

Wei, Y., & Koulakov, A. A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3929-12.2014 · Cited by 29 · see citing works

The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening

Lai, Y., Lou, X., Jho, Y., Yoon, T.-Y., & Shin, Y.-K. (2013) · Biochemical Journal · doi:10.1042/bj20130949 · Cited by 28 · see citing works

Synaptic Density and Neuronal Metabolic Function Measured by Positron Emission Tomography in the Unilateral 6-OHDA Rat Model of Parkinson’s Disease

Raval, N. R., Gudmundsen, F., Juhl, M., Andersen, I. V., Speth, N., Videbæk, A., Petersen, I. N., Mikkelsen, J. D., Fisher, P. M., Herth, M. M., et al. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.715811 · Cited by 22 · see citing works

Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression

Asch, R. H., Abdallah, C. G., Carson, R. E., & Esterlis, I. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-024-01913-3 · Cited by 13 · see citing works

Measurement of intact quantal packet of transmitters released from single nerve terminal by loose-patch amperometry

Chen, P., Shen, X., Zhao, S., Liu, Z., Zhu, Q., Zhu, T., Zhang, S., Li, Y., Mao, L., & Sun, J. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113143 · Cited by 5 · see citing works

SIP30 involvement in vesicle exocytosis from PC12 cells

Guo, N., & Yu, L. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101614 · Cited by 2 · see citing works

Ca 2+ Dependence of Synaptic Vesicle Endocytosis

Leitz, J., & Kavalali, E. T. (2015) · The Neuroscientist · doi:10.1177/1073858415588265 · Cited by 43 · see citing works

The synaptic vesicle cycle: exocytosis and endocytosis in Drosophila and C. elegans

Richmond, J. E., & Broadie, K. S. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00360-4 · Cited by 112 · see citing works

What is the function of neuronal AP‐3?

Danglot, L., & Galli, T. (2007) · Biology of the Cell · doi:10.1042/bc20070029 · Cited by 57 · see citing works

Quantitative Analysis of Domain Formation after Snare Mediated Fusion of Synaptic Vesicles

Fernandes, F., Holt, M. G., van den Bogaart, G., et al. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2009.12.3728