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Cited by 542

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

A unique wheat disease resistance-like gene governs effector-triggered susceptibility to necrotrophic pathogens

Open access
Faris, Justin D., Zhang, Zengcui, Lu, Huangjun, Lu, Shunwen, Reddy, Leela, Cloutier, Sylvie, Fellers, John P., Meinhardt, Steven W., Rasmussen, Jack B., Xu, Steven S., Oliver, Richard P., Simons, Kristin J., Friesen, Timothy L.·2010·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1004090107
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Abstract

Plant disease resistance is often conferred by genes with nucleotide binding site (NBS) and leucine-rich repeat (LRR) or serine/threonine protein kinase (S/TPK) domains. Much less is known about mechanisms of susceptibility, particularly to necrotrophic fungal pathogens. The pathogens that cause the diseases tan spot and Stagonospora nodorum blotch on wheat produce effectors (host-selective toxins) that induce susceptibility in wheat lines harboring corresponding toxin sensitivity genes. The effector ToxA is produced by both pathogens, and sensitivity to ToxA is governed by the Tsn1 gene on wheat chromosome arm 5BL. Here, we report the cloning of Tsn1 , which was found to have disease resistance gene-like features, including S/TPK and NBS-LRR domains. Mutagenesis revealed that all three domains are required for ToxA sensitivity, and hence disease susceptibility. Tsn1 is unique to ToxA-sensitive genotypes, and insensitive genotypes are null. Sequencing and phylogenetic analysis indicated that Tsn1 arose in the B-genome diploid progenitor of polyploid wheat through a gene-fusion event that gave rise to its unique structure. Although Tsn1 is necessary to mediate ToxA recognition, yeast two-hybrid experiments suggested that the Tsn1 protein does not interact directly with ToxA. Tsn1 transcription is tightly regulated by the circadian clock and light, providing further evidence that Tsn1 -ToxA interactions are associated with photosynthesis pathways. This work suggests that these necrotrophic pathogens may thrive by subverting the resistance mechanisms acquired by plants to combat other pathogens.

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Metadata

Authors
Faris, J. D., Zhang, Z., Lu, H., Lu, S., Reddy, L., Cloutier, S., Fellers, J. P., Meinhardt, S. W., Rasmussen, J. B., Xu, S. S., Oliver, R. P., Simons, K. J., & Friesen, T. L.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2010-07-12
Volume
107
Issue
30
Pages
13544-13549
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1004090107
OpenAlex
W2139627950
Cited by
542
References
13
FWCI
25.47
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: A unique wheat disease resistance-like gene governs effector-triggered susceptibility to necrotrophic pathogens. https://app.cochat.ai/papers/10.1073/pnas.1004090107
The paper
Faris, J. D., Zhang, Z., Lu, H., Lu, S., Reddy, L., Cloutier, S., Fellers, J. P., Meinhardt, S. W., Rasmussen, J. B., Xu, S. S., Oliver, R. P., Simons, K. J., & Friesen, T. L. (2010). A unique wheat disease resistance-like gene governs effector-triggered susceptibility to necrotrophic pathogens. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1004090107

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.