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Expansion of human NK-22 cells with IL-7, IL-2, and IL-1β reveals intrinsic functional plasticity
Open accessAbstract
Natural killer-22 (NK-22) cells are a human NK cell subset situated in mucosal-associated lymphoid tissues that specialize in IL-22 secretion in response to IL-23. Here we investigated the cytokine requirements for NK-22 cell expansion. IL-7 maintained the sur-vival of NK-22 cells and IL-22 production in response to IL-23 but was insufficient to induce robust expansion. Proliferation of NK-22 cells was increased markedly by adding either IL-1β or IL-2 to IL-7 and was even stronger in the presence of IL-1β plus IL-2. In contrast to IL-7, continuous culture in IL-1β and IL-2 modified NK-22 cytokine profiles. IL-1β promoted constitutive IL-22 secretion rather than acute IL-22 production in response to IL-23 and induced IL-17 in some cells. IL-2 reduced secretion of IL-22 and IL-17, increasing production of IFN-γ and leukemia inhibitory factor. Functional deviation toward IFN-γ production also was induced by continuous culture in IL-23. These results demonstrate the functional plasticity of NK-22 cells, which may allow flexible responses to different pathogens. Finally, we found that NK-22 cells released the B-cell survival factor, B-cell activating factor belonging to the TNF family (BAFF), suggesting a potential role of NK-22 cells in promoting B-cell–mediated mucosal immunity.
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Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.005 · Cited by 1,053
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Metadata
- Authors
- Cella, M., Otero, K., & Colonna, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-06
- Volume
- 107
- Issue
- 24
- Pages
- 10961-10966
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1982840915
- Cited by
- 350
- References
- 2
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cella, M., Otero, K., & Colonna, M. (2010). Expansion of human NK-22 cells with IL-7, IL-2, and IL-1β reveals intrinsic functional plasticity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1005641107
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