The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants
Open accessAbstract
Microorganisms and their hosts communicate with each other through an array of signals. The plant hormone auxin (indole-3-acetic acid; IAA) is central in many aspects of plant development. Cyclodipeptides and their derivative diketopiperazines (DKPs) constitute a large class of small molecules synthesized by microorganisms with diverse and noteworthy activities. Here, we present genetic, chemical, and plant-growth data showing that in Pseudomonas aeruginosa , the LasI quorum-sensing (QS) system controls the production of three DKPs—namely, cyclo( l -Pro- l -Val), cyclo( l -Pro- l -Phe), and cyclo( l -Pro- l -Tyr)—that are involved in plant growth promotion by this bacterium. Analysis of all three bacterial DKPs in Arabidopsis thaliana seedlings provided detailed information indicative of an auxin-like activity, based on their efficacy at modulating root architecture, activation of auxin-regulated gene expression, and response of auxin-signaling mutants tir1 , tir1 afb2 afb3 , arf7 , arf19 , and arf7arf19 . The observation that QS-regulated bacterial production of DKPs modulates auxin signaling and plant growth promotion establishes an important function for DKPs mediating prokaryote/eukaryote transkingdom signaling.
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Cites
The F-box protein TIR1 is an auxin receptor
Dharmasiri, N., Dharmasiri, S., & Estelle, M. (2005) · Nature · doi:10.1038/nature03543 · Cited by 2,083
Mechanism of auxin perception by the TIR1 ubiquitin ligase
Tan, X., Calderon-Villalobos, L. I. A., Sharon, M., Zheng, C., Robinson, C. V., Estelle, M., & Zheng, N. (2007) · Nature · doi:10.1038/nature05731 · Cited by 1,688
Plant Development Is Regulated by a Family of Auxin Receptor F Box Proteins
Dharmasiri, N., Dharmasiri, S., Weijers, D., Lechner, E., Yamada, M., Hobbie, L., Ehrismann, J. S., Jürgens, G., & Estelle, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.05.014 · Cited by 997
Bacteria–host communication: the language of hormones
Sperandio, V., Torres, A. G., Jarvis, B., Nataro, J. P., & Kaper, J. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1537100100 · Cited by 902
Ström, K., Sjögren, J., Broberg, A., & Schnürer, J. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.9.4322-4327.2002 · Cited by 627
Auxin Perception--Structural Insights
Calderon-Villalobos, L. I., Tan, X., Zheng, N., & Estelle, M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005546 · Cited by 177
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Weiss, I. M., Muth, C., Drumm, R., & Kirchner, H. O. K. (2018) · BMC Biophysics · doi:10.1186/s13628-018-0042-4 · Cited by 404
VOCs-mediated hormonal signaling and crosstalk with plant growth promoting microbes
Tyagi, S., Mulla, S. I., Lee, K.-J., Chae, J.-C., & Shukla, P. (2018) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2018.1472551 · Cited by 138
2, 5-diketopiperazines in food and beverages: Taste and bioactivity
Borthwick, A. D., & Da Costa, N. C. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.911142 · Cited by 92
Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament
Sutherland, E., Harding, C. J., du Monceau de Bergendal, T., Florence, G. J., Ackermann, K., Bode, B. E., Synowsky, S., Sundaramoorthy, R., & Czekster, C. M. (2025) · Nature Communications · doi:10.1038/s41467-025-56127-y · Cited by 2
Metadata
- Authors
- Ortiz-Castro, R., Díaz-Pérez, C., Martínez-Trujillo, M., del Río, R. E., Campos-García, J., & López-Bucio, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-04-11
- Volume
- 108
- Issue
- 17
- Pages
- 7253-7258
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052036460
- Cited by
- 249
- References
- 6
- FWCI
- 15.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Ortiz-Castro, R., Díaz-Pérez, C., Martínez-Trujillo, M., del Río, R. E., Campos-García, J., & López-Bucio, J. (2011). Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1006740108
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