The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Association mapping of local climate-sensitive quantitative trait loci in Arabidopsis thaliana
Open accessAbstract
Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation. We dissected natural variation in FT across a new global diversity set of 473 unique accessions, with >12,000 plants across two seasonal plantings in each of two simulated local climates, Spain and Sweden. Genome-wide association mapping was carried out with 213,497 SNPs. A total of 12 FT candidate quantitative trait loci (QTL) were fine-mapped in two independent studies, including 4 located within ±10 kb of previously cloned FT alleles and 8 novel loci. All QTL show sensitivity to planting season and/or simulated location in a multi-QTL mixed model. Alleles at four QTL were significantly correlated with latitude of origin, implying past selection for faster flowering in southern locations. Finally, maximum seed yield was observed at an optimal FT unique to each season and location, with four FT QTL directly controlling yield. Our results suggest that these major, environmentally sensitive FT QTL play an important role in spatial and temporal adaptation.
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PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089
Variance component model to account for sample structure in genome-wide association studies
Kang, H. M., Sul, J. H., Service, S. K., Zaitlen, N. A., Kong, S.-Y., Freimer, N. B., Sabatti, C., & Eskin, E. (2010) · Nature Genetics · doi:10.1038/ng.548 · Cited by 2,817
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines
Atwell, S., Huang, Y. S., Vilhjálmsson, B. J., Willems, G., Horton, M., Li, Y., Meng, D., Platt, A., Tarone, A. M., Hu, T. T., et al. (2010) · Nature · doi:10.1038/nature08800 · Cited by 1,780
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Cited by
Yang, W., Guo, Z., Huang, C., Duan, L., Chen, G., Jiang, N., Fang, W., Feng, H., Xie, W., Lian, X., et al. (2014) · Nature Communications · doi:10.1038/ncomms6087 · Cited by 598
Horton, M. W., Hancock, A. M., Huang, Y. S., Toomajian, C., Atwell, S., Auton, A., Muliyati, N. W., Platt, A., Sperone, F. G., Vilhjálmsson, B. J., et al. (2012) · Nature Genetics · doi:10.1038/ng.1042 · Cited by 543
Self-citationKorte, A., Vilhjálmsson, B. J., Segura, V., Platt, A., Long, Q., & Nordborg, M. (2012) · Nature Genetics · doi:10.1038/ng.2376 · Cited by 446
Self-citationEvolutionary genetics of plant adaptation
Anderson, J. T., Willis, J. H., & Mitchell-Olds, T. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.04.001 · Cited by 434
Famoso, A. N., Zhao, K., Clark, R. T., Tung, C.-W., Wright, M. H., Bustamante, C., Kochian, L. V., & McCouch, S. R. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002221 · Cited by 385
Metadata
- Authors
- Li, Y., Huang, Y., Bergelson, J., Nordborg, M., & Borevitz, J. O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-11-15
- Volume
- 107
- Issue
- 49
- Pages
- 21199-21204
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035422475
- Cited by
- 293
- References
- 3
- FWCI
- 11.40
- Type
- journal article
- Language
- en
- Open access
- green
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