The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Roles of epithelial cell-derived periostin in TGF-β activation, collagen production, and collagen gel elasticity in asthma
Open accessAbstract
Periostin is considered to be a matricellular protein with expression typically confined to cells of mesenchymal origin. Here, by using in situ hybridization, we show that periostin is specifically up-regulated in bronchial epithelial cells of asthmatic subjects, and in vitro, we show that periostin protein is basally secreted by airway epithelial cells in response to IL-13 to influence epithelial cell function, epithelial–mesenchymal interactions, and extracellular matrix organization. In primary human bronchial epithelial cells stimulated with periostin and epithelial cells overexpressing periostin, we reveal a function for periostin in stimulating the TGF-β signaling pathway in a mechanism involving matrix metalloproteinases 2 and 9. Furthermore, conditioned medium from the epithelial cells overexpressing periostin caused TGF-β–dependent secretion of type 1 collagen by airway fibroblasts. In addition, mixing recombinant periostin with type 1 collagen in solution caused a dramatic increase in the elastic modulus of the collagen gel, indicating that periostin alters collagen fibrillogenesis or cross-linking and leads to stiffening of the matrix. Epithelial cell-derived periostin in asthma has roles in TGF-β activation and collagen gel elasticity in asthma.
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Woodruff, P. G., Boushey, H. A., Dolganov, G. M., Barker, C. S., Yang, Y. H., Donnelly, S., Ellwanger, A., Sidhu, S. S., Dao-Pick, T. P., Pantoja, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707413104 · Cited by 828
Self-citationAbe, M., Harpel, J. G., Metz, C. N., Nunes, I., Loskutoff, D. J., & Rifkin, D. B. (1994) · Analytical Biochemistry · doi:10.1006/abio.1994.1042 · Cited by 757
Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients
Araya, J., Cambier, S., Markovics, J. A., Wolters, P., Jablons, D., Hill, A., Finkbeiner, W., Jones, K., Broaddus, V. C., Sheppard, D., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32526 · Cited by 257
Essential Role of TGF-β Signaling in Glucose-Induced Cell Hypertrophy
Wu, L., & Derynck, R. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.05.010 · Cited by 167
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Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
Jia, G., Erickson, R. W., Choy, D. F., Mosesova, S., Wu, L. C., Solberg, O. D., Shikotra, A., Carter, R., Audusseau, S., Hamid, Q., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.06.025 · Cited by 615
Self-citationDuchamp de Lageneste, O., Julien, A., Abou-Khalil, R., Frangi, G., Carvalho, C., Cagnard, N., Cordier, C., Conway, S. J., & Colnot, C. (2018) · Nature Communications · doi:10.1038/s41467-018-03124-z · Cited by 555
Hanania, N. A., Korenblat, P., Chapman, K. R., Bateman, E. D., Kopecky, P., Paggiaro, P., Yokoyama, A., Olsson, J., Gray, S., Holweg, C. T. J., et al. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(16)30265-x · Cited by 469
Periostin promotes chronic allergic inflammation in response to Th2 cytokines
Masuoka, M., Shiraishi, H., Ohta, S., Suzuki, S., Arima, K., Aoki, S., Toda, S., Inagaki, N., Kurihara, Y., Hayashida, S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58978 · Cited by 388
Metadata
- Authors
- Sidhu, S. S., Yuan, S., Innes, A. L., Kerr, S., Woodruff, P. G., Hou, L., Muller, S. J., & Fahy, J. V.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-07-26
- Volume
- 107
- Issue
- 32
- Pages
- 14170-14175
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1981782394
- Cited by
- 384
- References
- 4
- FWCI
- 15.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Sidhu, S. S., Yuan, S., Innes, A. L., Kerr, S., Woodruff, P. G., Hou, L., Muller, S. J., & Fahy, J. V. (2010). Roles of epithelial cell-derived periostin in TGF-β activation, collagen production, and collagen gel elasticity in asthma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1009426107
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
