The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin
Open accessAbstract
Bone regeneration relies on the activation of skeletal stem cells (SSCs) that still remain poorly characterized. Here, we show that periosteum contains SSCs with high bone regenerative potential compared to bone marrow stromal cells/skeletal stem cells (BMSCs) in mice. Although periosteal cells (PCs) and BMSCs are derived from a common embryonic mesenchymal lineage, postnatally PCs exhibit greater clonogenicity, growth and differentiation capacity than BMSCs. During bone repair, PCs can efficiently contribute to cartilage and bone, and integrate long-term after transplantation. Molecular profiling uncovers genes encoding Periostin and other extracellular matrix molecules associated with the enhanced response to injury of PCs. Periostin gene deletion impairs PC functions and fracture consolidation. Periostin-deficient periosteum cannot reconstitute a pool of PCs after injury demonstrating the presence of SSCs within periosteum and the requirement of Periostin in maintaining this pool. Overall our results highlight the importance of analyzing periosteum and PCs to understand bone phenotypes.
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Cited by
Liu, Y., Zhu, Z., Pei, X., Zhang, X., Cheng, X., Hu, S., Gao, X., Wang, J., Chen, J., & Wan, Q. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c12090 · Cited by 259
Fracture Healing in the Setting of Endocrine Diseases, Aging, and Cellular Senescence
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Zhao, L., Lai, Y., Jiao, H., & Huang, J. (2024) · Nature Communications · doi:10.1038/s41467-024-47633-6 · Cited by 69
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Metadata
- Authors
- Duchamp de Lageneste, O., Julien, A., Abou-Khalil, R., Frangi, G., Carvalho, C., Cagnard, N., Cordier, C., Conway, S. J., & Colnot, C.
- Venue
- Nature Communications
- Published
- 2018-02-22
- Volume
- 9
- Issue
- 1
- Pages
- 773-773
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2790664419
- Cited by
- 555
- References
- 67
- FWCI
- 25.27
- Type
- journal article
- Language
- en
- Open access
- gold
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- Duchamp de Lageneste, O., Julien, A., Abou-Khalil, R., Frangi, G., Carvalho, C., Cagnard, N., Cordier, C., Conway, S. J., & Colnot, C. (2018). Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. Nature Communications. https://doi.org/10.1038/s41467-018-03124-z
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