The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism
Open accessAbstract
The human APOBEC3 ( A3A–A3H ) locus encodes six cytidine deaminases that edit single-stranded DNA, the result being DNA peppered with uridine. Although several cytidine deaminases are clearly restriction factors for retroviruses and hepadnaviruses, it is not known if APOBEC3 enzymes have roles outside of these settings. It is shown here that both human mitochondrial and nuclear DNA are vulnerable to somatic hypermutation by A3 deaminases, with APOBEC3A standing out among them. The degree of editing is much greater in patients lacking the uracil DNA-glycolyase gene, indicating that the observed levels of editing reflect a dynamic composed of A3 editing and DNA catabolism involving uracil DNA-glycolyase. Nonetheless, hyper- and lightly mutated sequences went hand in hand, raising the hypothesis that recurrent low-level mutation by APOBEC3A could catalyze the transition from a healthy to a cancer genome.
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Cites
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
Mangeat, B., Turelli, P., Caron, G., Friedli, M., Perrin, L., & Trono, D. (2003) · Nature · doi:10.1038/nature01709 · Cited by 1,486
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Nik-Zainal, S., Wedge, D. C., Alexandrov, L. B., Petljak, M., Butler, A. P., Bolli, N., Davies, H. R., Knappskog, S., Martin, S., Papaemmanuil, E., et al. (2014) · Nature Genetics · doi:10.1038/ng.2955 · Cited by 277
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Arbeithuber, B., Cremona, M. A., Hester, J., Barrett, A., Higgins, B., Anthony, K., Chiaromonte, F., Diaz, F. J., & Makova, K. D. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118740119 · Cited by 40
Metadata
- Authors
- Suspène, R., Aynaud, M.-M., Guétard, D., Henry, M., Eckhoff, G., Marchio, A., Pineau, P., Dejean, A., Vartanian, J.-P., & Wain-Hobson, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-03-02
- Volume
- 108
- Issue
- 12
- Pages
- 4858-4863
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977239712
- Cited by
- 172
- References
- 2
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Suspène, R., Aynaud, M.-M., Guétard, D., Henry, M., Eckhoff, G., Marchio, A., Pineau, P., Dejean, A., Vartanian, J.-P., & Wain-Hobson, S. (2011). Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1009687108
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