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Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity
Open accessAbstract
Retinopathy of prematurity is a blinding disease, initiated by lack of retinal vascular growth after premature birth. We show that lack of insulin-like growth factor I (IGF-I) in knockout mice prevents normal retinal vascular growth, despite the presence of vascular endothelial growth factor, important to vessel development. In vitro , low levels of IGF-I prevent vascular endothelial growth factor-induced activation of protein kinase B (Akt), a kinase critical for endothelial cell survival. Our results from studies in premature infants suggest that if the IGF-I level is sufficient after birth, normal vessel development occurs and retinopathy of prematurity does not develop. When IGF-I is persistently low, vessels cease to grow, maturing avascular retina becomes hypoxic and vascular endothelial growth factor accumulates in the vitreous. As IGF-I increases to a critical level, retinal neovascularization is triggered. These data indicate that serum IGF-I levels in premature infants can predict which infants will develop retinopathy of prematurity and further suggests that early restoration of IGF-I in premature infants to normal levels could prevent this disease.
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Cited by
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SanGiovanni, J. P., & Chew, E. Y. (2005) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.06.002 · Cited by 874
Retinopathy of prematurity: a review of risk factors and their clinical significance
Kim, S. J., Port, A. D., Swan, R., Campbell, J. P., Chan, R. V. P., & Chiang, M. F. (2018) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2018.04.002 · Cited by 579
Metadata
- Authors
- Hellstrom, A., Perruzzi, C., Ju, M., Engström, E., Hård, A.-L., Liu, J.-L., Albertsson-Wikland, K., Carlsson, B., Niklasson, A., Sjödell, L., LeRoith, D., Senger, D. R., & Smith, L. E. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-05
- Volume
- 98
- Issue
- 10
- Pages
- 5804-5808
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2153259848
- Cited by
- 583
- References
- 0
- FWCI
- 18.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Hellstrom, A., Perruzzi, C., Ju, M., Engström, E., Hård, A.-L., Liu, J.-L., Albertsson-Wikland, K., Carlsson, B., Niklasson, A., Sjödell, L., LeRoith, D., Senger, D. R., & Smith, L. E. H. (2001). Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.101113998
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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