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Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors
Open accessAbstract
Endometrial stromal tumors are divided into three types: benign stromal nodules, endometrial stromal sarcomas, and undifferentiated endometrial sarcomas. A variety of cytogenetic abnormalities involving chromosome 7 have been reported in endometrial stromal sarcomas, including a recurrent t(7;17)(p15;q21). We have identified two zinc finger genes, which we have termed JAZF1 and JJAZ1 , at the sites of the 7p15 and 17q21 breakpoints. Analyses of tumor RNA indicate that a JAZF1 / JJAZ1 fusion is present in all types of endometrial stromal tumors; however, the fusion appears to be rarer among endometrial stromal sarcomas that would be considered high-grade according to certain classification schemes. These findings suggest that the less malignant endometrial stromal tumors may evolve toward more malignant types, but that some endometrial stromal sarcomas with relatively abundant mitotic activity may compose a biologically distinct group.
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Citations
Cited by
Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (2002) · Genes & Development · doi:10.1101/gad.1035902 · Cited by 1,596
Kim, K. H., & Roberts, C. W. M. (2016) · Nature Medicine · doi:10.1038/nm.4036 · Cited by 1,471
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Bracken, A. P., Pasini, D., Capra, M., Prosperini, E., Colli, E., & Helin, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg542 · Cited by 1,196
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
Pasini, D., Bracken, A. P., Jensen, M. R., Denchi, E. L., & Helin, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600402 · Cited by 916
Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer
Sauvageau, M., & Sauvageau, G. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.002 · Cited by 586
Metadata
- Authors
- Koontz, J. I., Soreng, A. L., Nucci, M., Kuo, F. C., Pauwels, P., van den Berghe, H., Cin, P. D., Fletcher, J. A., & Sklar, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-05-22
- Volume
- 98
- Issue
- 11
- Pages
- 6348-6353
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2119376406
- Cited by
- 390
- References
- 0
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Koontz, J. I., Soreng, A. L., Nucci, M., Kuo, F. C., Pauwels, P., van den Berghe, H., Cin, P. D., Fletcher, J. A., & Sklar, J. (2001). Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.101132598
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