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Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer
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“Aberrations in PRCs’ functionality were linked to several human cancers,120,121 significantly contributing to the self-renewal/differentiation balance of cancer stem cells,122,123,124 including GSCs.125”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [123]
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
Guttman, M., Amit, I., Garber, M., French, C., Lin, M. F., Feldser, D., Huarte, M., Zuk, O., Carey, B. W., Cassady, J. P., et al. (2009) · Nature · doi:10.1038/nature07672 · Cited by 4,098
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775
Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
The polycomb group protein EZH2 is involved in progression of prostate cancer
Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717
Kleer, C. G., Cao, Q., Varambally, S., Shen, R., Ota, I., Tomlins, S. A., Ghosh, D., Sewalt, R. G. A. B., Otte, A. P., Hayes, D. F., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1933744100 · Cited by 1,649
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452
Self-citationSchlesinger, Y., Straussman, R., Keshet, I., Farkash, S., Hecht, M., Zimmerman, J., Eden, E., Yakhini, Z., Ben-Shushan, E., Reubinoff, B. E., et al. (2007) · Nature Genetics · doi:10.1038/ng1950 · Cited by 1,226
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Bracken, A. P., Pasini, D., Capra, M., Prosperini, E., Colli, E., & Helin, K. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg542 · Cited by 1,196
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Research works printed but not linked: 168
- Agherbi, 2009, Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence, PLoS ONE, 4, e5622, 10.1371/journal.pone.0005622 · DOI
- Akasaka, 2002, MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation, Genes Cells, 7, 835, 10.1046/j.1365-2443.2002.00565.x · DOI
- Al-Hajj, 2003, Prospective identification of tumorigenic breast cancer cells, Proc. Natl. Acad. Sci. USA, 100, 3983, 10.1073/pnas.0530291100 · DOI
- Attwooll, 2005, A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner, J. Biol. Chem., 280, 1199, 10.1074/jbc.M412509200 · DOI
- Beck, 2010, Cell cycle defects in polyhomeotic mutants are caused by abrogation of the DNA damage checkpoint, Dev. Biol., 339, 320, 10.1016/j.ydbio.2009.12.031 · DOI
- Ben-Porath, 2008, An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors, Nat. Genet., 40, 499, 10.1038/ng.127 · DOI
- Bergink, 2006, DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A, Genes Dev., 20, 1343, 10.1101/gad.373706 · DOI
- Bernstein, 2006, Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin, Mol. Cell. Biol., 26, 2560, 10.1128/MCB.26.7.2560-2569.2006 · DOI
- Birney, 2007, Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project, Nature, 447, 799, 10.1038/nature05874 · DOI · Paper page
- Boccuni, 2003, The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6), J. Biol. Chem., 278, 15412, 10.1074/jbc.M300592200 · DOI
- Bonnet, 1997, Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell, Nat. Med., 3, 730, 10.1038/nm0797-730 · DOI
- Boukarabila, 2009, The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation, Genes Dev., 23, 1195, 10.1101/gad.512009 · DOI
- Boultwood, 2010, Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia, Leukemia, 24, 1062, 10.1038/leu.2010.20 · DOI · Paper page
- Boyer, 2006, Polycomb complexes repress developmental regulators in murine embryonic stem cells, Nature, 441, 349, 10.1038/nature04733 · DOI
- Bracken, 2009, Polycomb group proteins: navigators of lineage pathways led astray in cancer, Nat. Rev. Cancer, 9, 773, 10.1038/nrc2736 · DOI · Paper page
- Bracken, 2006, Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions, Genes Dev., 20, 1123, 10.1101/gad.381706 · DOI
- Cao, 2004, The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3, Curr. Opin. Genet. Dev., 14, 155, 10.1016/j.gde.2004.02.001 · DOI
- Cao, 2010, MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta, Mol. Cancer, 9, 108, 10.1186/1476-4598-9-108 · DOI
- Carbuccia, 2009, Mutations of ASXL1 gene in myeloproliferative neoplasms, Leukemia, 23, 2183, 10.1038/leu.2009.141 · DOI
- Carbuccia, 2010, Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias, Leukemia, 24, 469, 10.1038/leu.2009.218 · DOI
- Caretti, 2004, The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation, Genes Dev., 18, 2627, 10.1101/gad.1241904 · DOI
- Chagraoui, 2006, E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells, Genes Dev., 20, 2110, 10.1101/gad.1453406 · DOI
- Chamberlain, 2008, Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency, Stem Cells, 26, 1496, 10.1634/stemcells.2008-0102 · DOI
- Chatoo, 2009, The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity, J. Neurosci., 29, 529, 10.1523/JNEUROSCI.5303-08.2009 · DOI
- Choi, 2008, Prohibitin interacts with RNF2 and regulates E2F1 function via dual pathways, Oncogene, 27, 1716, 10.1038/sj.onc.1210806 · DOI
- Clarke, 2008, Spatial and temporal coordination of mitosis by Ran GTPase, Nat. Rev. Mol. Cell Biol., 9, 464, 10.1038/nrm2410 · DOI
- Czermin, 2002, Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites, Cell, 111, 185, 10.1016/S0092-8674(02)00975-3 · DOI
- Dahiya, 2001, Linking the Rb and polycomb pathways, Mol. Cell, 8, 557, 10.1016/S1097-2765(01)00346-X · DOI
- de Napoles, 2004, Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation, Dev. Cell, 7, 663, 10.1016/j.devcel.2004.10.005 · DOI
- Denisenko, 1998, Point mutations in the WD40 domain of Eed block its interaction with Ezh2, Mol. Cell. Biol., 18, 5634, 10.1128/MCB.18.10.5634 · DOI · Paper page
- Deshpande, 2007, PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors, Oncogene, 26, 1714, 10.1038/sj.onc.1209988 · DOI
- Ezhkova, 2009, Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells, Cell, 136, 1122, 10.1016/j.cell.2008.12.043 · DOI
- Fajas, 2000, pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F, Proc. Natl. Acad. Sci. USA, 97, 7738, 10.1073/pnas.130198397 · DOI
- Fasano, 2007, shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development, Cell Stem Cell, 1, 87, 10.1016/j.stem.2007.04.001 · DOI
- Fisher, 2010, Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia, Blood, 115, 38, 10.1182/blood-2009-07-230698 · DOI
- Francis, 2004, Chromatin compaction by a polycomb group protein complex, Science, 306, 1574, 10.1126/science.1100576 · DOI
- Francis, 2009, Polycomb proteins remain bound to chromatin and DNA during DNA replication in vitro, Cell, 137, 110, 10.1016/j.cell.2009.02.017 · DOI
- Friedman, 2009, The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2, Cancer Res., 69, 2623, 10.1158/0008-5472.CAN-08-3114 · DOI
- Furuta, 2010, miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma, Carcinogenesis, 31, 766, 10.1093/carcin/bgp250 · DOI
- García-Cuéllar, 2001, The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3, Oncogene, 20, 411, 10.1038/sj.onc.1204108 · DOI
- Gelsi-Boyer, 2009, Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia, Br. J. Haematol., 145, 788, 10.1111/j.1365-2141.2009.07697.x · DOI
- Godlewski, 2008, Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal, Cancer Res., 68, 9125, 10.1158/0008-5472.CAN-08-2629 · DOI · Paper page
- Gong, 2006, NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element, Nucleic Acids Res., 34, 6158, 10.1093/nar/gkl834 · DOI
- González, 2009, The Polyhomeotic protein induces hyperplastic tissue overgrowth through the activation of the JAK/STAT pathway, Cell Cycle, 8, 4103, 10.4161/cc.8.24.10212 · DOI
- Grimm, 2009, Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt, EMBO J., 28, 1965, 10.1038/emboj.2009.147 · DOI
- Guo, 2007, Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells, Cancer Res., 67, 5083, 10.1158/0008-5472.CAN-06-4368 · DOI
- Gupta, 2010, Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis, Nature, 464, 1071, 10.1038/nature08975 · DOI
- Hansen, 2008, A model for transmission of the H3K27me3 epigenetic mark, Nat. Cell Biol., 10, 1291, 10.1038/ncb1787 · DOI
- Haupt, 1993, bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis, Oncogene, 8, 3161
- Hemenway, 2001, The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias, Oncogene, 20, 3798, 10.1038/sj.onc.1204478 · DOI
- Hirabayashi, 2009, Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition, Neuron, 63, 600, 10.1016/j.neuron.2009.08.021 · DOI
- Hong, 2008, A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell, Nucleic Acids Res., 36, 2939, 10.1093/nar/gkn146 · DOI
- Huen, 2008, Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication, J. Biol. Chem., 283, 11073, 10.1074/jbc.C700242200 · DOI
- Iwata, 2010, Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma, Cancer Sci., 101, 1646, 10.1111/j.1349-7006.2010.01586.x · DOI
- Jacobs, 1999, Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF, Genes Dev., 13, 2678, 10.1101/gad.13.20.2678 · DOI
- Jang, 2007, A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche, Blood, 110, 3056, 10.1182/blood-2007-05-087759 · DOI · Paper page
- Jin, 2009, DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer, Cancer Res., 69, 7412, 10.1158/0008-5472.CAN-09-0116 · DOI
- Jørgensen, 2007, The histone methyltransferase SET8 is required for S-phase progression, J. Cell Biol., 179, 1337, 10.1083/jcb.200706150 · DOI
- Joseph, 2002, SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles, J. Cell Biol., 156, 595, 10.1083/jcb.200110109 · DOI
- Juan, 2009, Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells, Mol. Cell, 36, 61, 10.1016/j.molcel.2009.08.008 · DOI
- Kalakonda, 2008, Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1, Oncogene, 27, 4293, 10.1038/onc.2008.67 · DOI
- Kamminga, 2006, The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion, Blood, 107, 2170, 10.1182/blood-2005-09-3585 · DOI · Paper page
- Kerppola, 2009, Polycomb group complexes—many combinations, many functions, Trends Cell Biol., 19, 692, 10.1016/j.tcb.2009.10.001 · DOI
- Kheradmand Kia, 2009, EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence, Epigenetics Chromatin, 2, 16, 10.1186/1756-8935-2-16 · DOI
- Kim, 2008, DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription, Int. J. Biochem. Cell Biol., 40, 2462, 10.1016/j.biocel.2008.04.018 · DOI
- Kirmizis, 2004, Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27, Genes Dev., 18, 1592, 10.1101/gad.1200204 · DOI
- Klein, 2009, SUMO-dependent regulation of centrin-2, J. Cell Sci., 122, 3312, 10.1242/jcs.050245 · DOI
- Koga, 1999, A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes, Oncogene, 18, 3799, 10.1038/sj.onc.1202732 · DOI
- Kotake, 2007, pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene, Genes Dev., 21, 49, 10.1101/gad.1499407 · DOI
- Kozaki, 2008, Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer, Cancer Res., 68, 2094, 10.1158/0008-5472.CAN-07-5194 · DOI
- Krivtsov, 2007, MLL translocations, histone modifications and leukaemia stem-cell development, Nat. Rev. Cancer, 7, 823, 10.1038/nrc2253 · DOI
- Ku, 2008, Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains, PLoS Genet., 4, e1000242, 10.1371/journal.pgen.1000242 · DOI
- Kuzmichev, 2002, Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein, Genes Dev., 16, 2893, 10.1101/gad.1035902 · DOI · Paper page
- Landeira, 2010, Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators, Nat. Cell Biol., 12, 618, 10.1038/ncb2065 · DOI
- Le Cam, 2006, E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation, Cell, 127, 775, 10.1016/j.cell.2006.09.031 · DOI
- Lee, 2006, Control of developmental regulators by Polycomb in human embryonic stem cells, Cell, 125, 301, 10.1016/j.cell.2006.02.043 · DOI
- Lee, 2008, Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis, J. Invest. Dermatol., 128, 9, 10.1038/sj.jid.5700949 · DOI
- Levine, 2002, The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans, Mol. Cell. Biol., 22, 6070, 10.1128/MCB.22.17.6070-6078.2002 · DOI
- Li, 2007, Identification of pancreatic cancer stem cells, Cancer Res., 67, 1030, 10.1158/0008-5472.CAN-06-2030 · DOI
- Lu, 2007, A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression, Proc. Natl. Acad. Sci. USA, 104, 9381, 10.1073/pnas.0610279104 · DOI
- Luo, 2004, The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions, Nature, 427, 749, 10.1038/nature02305 · DOI
- Maertens, 2009, Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus, PLoS ONE, 4, e6380, 10.1371/journal.pone.0006380 · DOI
- Majewski, 2008, Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity, PLoS Biol., 6, e93, 10.1371/journal.pbio.0060093 · DOI
- Marson, 2008, Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells, Cell, 134, 521, 10.1016/j.cell.2008.07.020 · DOI
- Martinez, 2009, A microarray-based DNA methylation study of glioblastoma multiforme, Epigenetics, 4, 255, 10.4161/epi.9130 · DOI
- Miyagishima, 2003, Dissociation of mammalian Polycomb-group proteins, Ring1B and Rae28/Ph1, from the chromatin correlates with configuration changes of the chromatin in mitotic and meiotic prophase, Histochem. Cell Biol., 120, 111, 10.1007/s00418-003-0551-2 · DOI
- Mohammad, 2009, Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation, Cancer Res., 69, 6322, 10.1158/0008-5472.CAN-09-0065 · DOI
- Molofsky, 2005, Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways, Genes Dev., 19, 1432, 10.1101/gad.1299505 · DOI
- Morin, 2010, Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin, Nat. Genet., 42, 181, 10.1038/ng.518 · DOI
- Negishi, 2007, Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing, Biochem. Biophys. Res. Commun., 353, 992, 10.1016/j.bbrc.2006.12.166 · DOI
- Nekrasov, 2007, Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes, EMBO J., 26, 4078, 10.1038/sj.emboj.7601837 · DOI
- Nikoloski, 2010, Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes, Nat. Genet., 42, 665, 10.1038/ng.620 · DOI
- O'Brien, 2007, A human colon cancer cell capable of initiating tumour growth in immunodeficient mice, Nature, 445, 106, 10.1038/nature05372 · DOI
- O'Dor, 2006, Polycomb group mutants exhibit mitotic defects in syncytial cell cycles of Drosophila embryos, Dev. Biol., 290, 312, 10.1016/j.ydbio.2005.11.015 · DOI
- O'Riain, 2009, Array-based DNA methylation profiling in follicular lymphoma, Leukemia, 23, 1858, 10.1038/leu.2009.114 · DOI
- Oda, 2009, Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development, Mol. Cell. Biol., 29, 2278, 10.1128/MCB.01768-08 · DOI
- Oguro, 2006, Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice, J. Exp. Med., 203, 2247, 10.1084/jem.20052477 · DOI
- Oguro, 2010, Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1, Cell Stem Cell, 6, 279, 10.1016/j.stem.2010.01.005 · DOI
- Ohtsubo, 2008, Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity, Proc. Natl. Acad. Sci. USA, 105, 10396, 10.1073/pnas.0800672105 · DOI
- Owusu-Ansah, 2009, Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation, Nature, 461, 537, 10.1038/nature08313 · DOI · Paper page
- Pan, 2007, Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells, Cell Stem Cell, 1, 299, 10.1016/j.stem.2007.08.003 · DOI · Paper page
- Pasini, 2004, Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity, EMBO J., 23, 4061, 10.1038/sj.emboj.7600402 · DOI
- Pasini, 2007, The polycomb group protein Suz12 is required for embryonic stem cell differentiation, Mol. Cell. Biol., 27, 3769, 10.1128/MCB.01432-06 · DOI
- Pasini, 2008, Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2, Genes Dev., 22, 1345, 10.1101/gad.470008 · DOI
- Peng, 2009, Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells, Cell, 139, 1290, 10.1016/j.cell.2009.12.002 · DOI
- Peterson, 1997, A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions, Mol. Cell. Biol., 17, 6683, 10.1128/MCB.17.11.6683 · DOI
- Peterson, 2004, Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression, Genetics, 167, 1225, 10.1534/genetics.104.027474 · DOI
- Rajasekhar, 2007, Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective, Stem Cells, 25, 2498, 10.1634/stemcells.2006-0608 · DOI
- Rice, 2002, Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes, Genes Dev., 16, 2225, 10.1101/gad.1014902 · DOI
- Richie, 2002, The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomas, Oncogene, 21, 299, 10.1038/sj.onc.1205051 · DOI
- Rinn, 2007, Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs, Cell, 129, 1311, 10.1016/j.cell.2007.05.022 · DOI
- Roh, 2006, The genomic landscape of histone modifications in human T cells, Proc. Natl. Acad. Sci. USA, 103, 15782, 10.1073/pnas.0607617103 · DOI
- Roscic, 2006, Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2, Mol. Cell, 24, 77, 10.1016/j.molcel.2006.08.004 · DOI
- Rossi, 2007, Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging, Cell Cycle, 6, 2371, 10.4161/cc.6.19.4759 · DOI
- Rouleau, 2007, PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery, J. Cell. Biochem., 100, 385, 10.1002/jcb.21051 · DOI
- Ruzankina, 2007, Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss, Cell Stem Cell, 1, 113, 10.1016/j.stem.2007.03.002 · DOI
- Sánchez, 2007, Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor, Mol. Cell. Proteomics, 6, 820, 10.1074/mcp.M600275-MCP200 · DOI
- Sander, 2008, MYC stimulates EZH2 expression by repression of its negative regulator miR-26a, Blood, 112, 4202, 10.1182/blood-2008-03-147645 · DOI
- Saramäki, 2006, The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer, Genes Chromosomes Cancer, 45, 639, 10.1002/gcc.20327 · DOI
- Sarma, 2008, Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo, Mol. Cell. Biol., 28, 2718, 10.1128/MCB.02017-07 · DOI
- Sauvageau, 2008, Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia, Blood, 111, 790, 10.1182/blood-2007-07-098236 · DOI
- Scheuermann, 2010, Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB, Nature, 465, 243, 10.1038/nature08966 · DOI
- Schoeftner, 2006, Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing, EMBO J., 25, 3110, 10.1038/sj.emboj.7601187 · DOI
- Schuettengruber, 2009, Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice, Development, 136, 3531, 10.1242/dev.033902 · DOI
- Schwartz, 2007, Polycomb silencing mechanisms and the management of genomic programmes, Nat. Rev. Genet., 8, 9, 10.1038/nrg1981 · DOI · Paper page
- Shen, 2008, EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency, Mol. Cell, 32, 491, 10.1016/j.molcel.2008.10.016 · DOI · Paper page
- Shen, 2009, Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells, Cell, 139, 1303, 10.1016/j.cell.2009.12.003 · DOI
- Shimono, 2009, Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells, Cell, 138, 592, 10.1016/j.cell.2009.07.011 · DOI
- Shumacher, 1996, Positional cloning of a global regulator of anterior-posterior patterning in mice, Nature, 383, 250, 10.1038/383250a0 · DOI
- Simon, 2009, Mechanisms of polycomb gene silencing: knowns and unknowns, Nat. Rev. Mol. Cell Biol., 10, 697, 10.1038/nrm2763 · DOI
- Singh, 2003, Identification of a cancer stem cell in human brain tumors, Cancer Res., 63, 5821
- Sparmann, 2006, Polycomb silencers control cell fate, development and cancer, Nat. Rev. Cancer, 6, 846, 10.1038/nrc1991 · DOI
- Su, 2009, MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity, Cancer Res., 69, 1135, 10.1158/0008-5472.CAN-08-2886 · DOI
- Surface, 2010, Polycomb group proteins set the stage for early lineage commitment, Cell Stem Cell, 7, 288, 10.1016/j.stem.2010.08.004 · DOI
- Suzuki, 2010, Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung, J. Immunol., 184, 4510, 10.4049/jimmunol.0903426 · DOI
- Tardat, 2007, PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase, J. Cell Biol., 179, 1413, 10.1083/jcb.200706179 · DOI
- Teschendorff, 2010, Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer, Genome Res., 20, 440, 10.1101/gr.103606.109 · DOI · Paper page
- Tetsu, 1998, mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25, Immunity, 9, 439, 10.1016/S1074-7613(00)80627-5 · DOI
- Tolhuis, 2006, Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster, Nat. Genet., 38, 694, 10.1038/ng1792 · DOI
- Tonini, 2004, Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A, Oncogene, 23, 4930, 10.1038/sj.onc.1207608 · DOI
- Trojer, 2007, L3MBTL1, a histone-methylation-dependent chromatin lock, Cell, 129, 915, 10.1016/j.cell.2007.03.048 · DOI
- Valk-Lingbeek, 2004, Stem cells and cancer; the polycomb connection, Cell, 118, 409, 10.1016/j.cell.2004.08.005 · DOI · Paper page
- van der Stoop, 2008, Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells, PLoS ONE, 3, e2235, 10.1371/journal.pone.0002235 · DOI
- van Haaften, 2009, Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer, Nat. Genet., 41, 521, 10.1038/ng.349 · DOI · Paper page
- van Lohuizen, 1998, Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes, Mol. Cell. Biol., 18, 3572, 10.1128/MCB.18.6.3572 · DOI
- Varambally, 2008, Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer, Science, 322, 1695, 10.1126/science.1165395 · DOI
- Villa, 2007, Role of the polycomb repressive complex 2 in acute promyelocytic leukemia, Cancer Cell, 11, 513, 10.1016/j.ccr.2007.04.009 · DOI
- Viré, 2006, The Polycomb group protein EZH2 directly controls DNA methylation, Nature, 439, 871, 10.1038/nature04431 · DOI · Paper page
- Voncken, 1999, Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status, J. Cell Sci., 112, 4627, 10.1242/jcs.112.24.4627 · DOI
- Wang, 2004, Role of histone H2A ubiquitination in Polycomb silencing, Nature, 431, 873, 10.1038/nature02985 · DOI
- Wang, 2009, Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger, Nature, 459, 847, 10.1038/nature08036 · DOI
- Wellner, 2009, The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs, Nat. Cell Biol., 11, 1487, 10.1038/ncb1998 · DOI
- Whitcomb, 2007, Polycomb Group proteins: an evolutionary perspective, Trends Genet., 23, 494, 10.1016/j.tig.2007.08.006 · DOI
- Wong, 2007, Polycomb group protein RING1B is a direct substrate of Caspases-3 and -9, Biochim. Biophys. Acta, 1773, 844, 10.1016/j.bbamcr.2007.02.005 · DOI
- Wu, 2010, Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression, Cell Death Differ., 17, 801, 10.1038/cdd.2009.162 · DOI
- Xiang, 2007, JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer, Proc. Natl. Acad. Sci. USA, 104, 19226, 10.1073/pnas.0700735104 · DOI · Paper page
- Yamashita, 2008, Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene, J. Exp. Med., 205, 1109, 10.1084/jem.20072000 · DOI
- Yang, 2009, CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells, PLoS ONE, 4, e5011, 10.1371/journal.pone.0005011 · DOI
- Yap, 2010, Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a, Mol. Cell, 38, 662, 10.1016/j.molcel.2010.03.021 · DOI · Paper page
- Yu, 2010, An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression, Cancer Cell, 17, 443, 10.1016/j.ccr.2010.03.018 · DOI · Paper page
- Zeidler, 2005, The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells, Neoplasia, 7, 1011, 10.1593/neo.05472 · DOI
- Zencak, 2005, Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation, J. Neurosci., 25, 5774, 10.1523/JNEUROSCI.3452-04.2005 · DOI
- Zhang, 2008, Mel-18 interacts with RanGAP1 and inhibits its sumoylation, Biochem. Biophys. Res. Commun., 375, 252, 10.1016/j.bbrc.2008.08.012 · DOI
- Zhang, 2007, Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence, J. Cell Sci., 120, 1572, 10.1242/jcs.003152 · DOI
- Zhang, 2008, MEL-18 interacts with HSF2 and the SUMO E2 UBC9 to inhibit HSF2 sumoylation, J. Biol. Chem., 283, 7464, 10.1074/jbc.M707122200 · DOI
- Zhang, 2008, Identification and characterization of ovarian cancer-initiating cells from primary human tumors, Cancer Res., 68, 4311, 10.1158/0008-5472.CAN-08-0364 · DOI
- Zhou, 2008, Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation, Mol. Cell, 29, 69, 10.1016/j.molcel.2007.11.002 · DOI
- Zhu, 2009, Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sites, DNA Repair (Amst.), 8, 262, 10.1016/j.dnarep.2008.11.007 · DOI
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Metadata
- Authors
- Sauvageau, M., & Sauvageau, G.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 7
- Issue
- 3
- Pages
- 299-313
- ISSN
- 1934-5909
- Cited by
- 586
- References
- 21
- Language
- en
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