The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness
Open accessAbstract
Recent data reveal that the general anesthetic propofol gives rise to a frontal α-rhythm at dose levels sufficient to induce loss of consciousness. In this work, a computational model is developed that suggests the network mechanisms responsible for such a rhythm. It is shown that propofol can alter the dynamics in thalamocortical loops, leading to persistent and synchronous α-activity. The synchrony that forms in the cortex by virtue of the involvement of the thalamus may impede responsiveness to external stimuli, thus providing a correlate for the unconscious state.
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Citations
Cites
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Cited by
General Anesthesia, Sleep, and Coma
Brown, E. N., Lydic, R., & Schiff, N. D. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0808281 · Cited by 1,350
Self-citationElectroencephalogram signatures of loss and recovery of consciousness from propofol
Purdon, P. L., Pierce, E. T., Mukamel, E. A., Prerau, M. J., Walsh, J. L., Wong, K. F. K., Salazar-Gomez, A. F., Harrell, P. G., Sampson, A. L., Cimenser, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221180110 · Cited by 854
Self-citationClinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures
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Self-citationMultimodal General Anesthesia: Theory and Practice
Brown, E. N., Pavone, K. J., & Naranjo, M. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000003668 · Cited by 521
Self-citationNeuronal Mechanisms and Attentional Modulation of Corticothalamic Alpha Oscillations
Bollimunta, A., Mo, J., Schroeder, C. E., & Ding, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5580-10.2011 · Cited by 441
Metadata
- Authors
- Ching, S., Cimenser, A., Purdon, P. L., Brown, E. N., & Kopell, N. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2010-12-13
- Volume
- 107
- Issue
- 52
- Pages
- 22665-22670
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2044670283
- Cited by
- 397
- References
- 39
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ching, S., Cimenser, A., Purdon, P. L., Brown, E. N., & Kopell, N. J. (2010). Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1017069108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
