The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Extranuclear protection of chromosomal DNA from oxidative stress
Open accessAbstract
Eukaryotic organisms evolved under aerobic conditions subjecting nuclear DNA to damage provoked by reactive oxygen species (ROS). Although ROS are thought to be a major cause of DNA damage, little is known about the molecular mechanisms protecting nuclear DNA from oxidative stress. Here we show that protection of nuclear DNA in plants requires a coordinated function of ROS-scavenging pathways residing in the cytosol and peroxisomes, demonstrating that nuclear ROS scavengers such as peroxiredoxin and glutathione are insufficient to safeguard DNA integrity. Both catalase (CAT2) and cytosolic ascorbate peroxidase (APX1) play a key role in protecting the plant genome against photorespiratory-dependent H 2 O 2 -induced DNA damage. In apx1/cat2 double-mutant plants, a DNA damage response is activated, suppressing growth via a WEE1 kinase-dependent cell-cycle checkpoint. This response is correlated with enhanced tolerance to oxidative stress, DNA stress-causing agents, and inhibited programmed cell death.
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Cites
Reactive oxygen species: Metabolism, oxidative stress, and signal transduction
Apel, K., & Hirt, H. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141701 · Cited by 11,723
Free Radicals in Biology and Medicine
Halliwell, B., & Gutteridge, J. M. C. (2015) · doi:10.1093/acprof:oso/9780198717478.001.0001 · Cited by 8,990
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438
The DNA Damage Response: Ten Years After
Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.015 · Cited by 1,705
Base-excision repair of oxidative DNA damage
David, S. S., O'Shea, V. L., & Kundu, S. (2007) · Nature · doi:10.1038/nature05978 · Cited by 1,238
Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions
Soutoglou, E., & Misteli, T. (2008) · Science · doi:10.1126/science.1159051 · Cited by 299
Cited by
Mittler, R. (2017) · Trends in Plant Science · doi:10.1016/j.tplants.2016.08.002 · Cited by 3,499
Self-citationReactive oxygen species signalling in plant stress responses
Mittler, R., Zandalinas, S. I., Fichman, Y., & Van Breusegem, F. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00499-2 · Cited by 2,351
Self-citationCatalase function in plants: a focus on Arabidopsis mutants as stress-mimic models
Mhamdi, A., Queval, G., Chaouch, S., Vanderauwera, S., Van Breusegem, F., & Noctor, G. (2010) · Journal of Experimental Botany · doi:10.1093/jxb/erq282 · Cited by 989
Self-citationMolecular Regulation of Plant Responses to Environmental Temperatures
Ding, Y., Shi, Y., & Yang, S. (2020) · Molecular Plant · doi:10.1016/j.molp.2020.02.004 · Cited by 787
Reactive oxygen species in plant development
Mhamdi, A., & Van Breusegem, F. (2018) · Development · doi:10.1242/dev.164376 · Cited by 667
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Metadata
- Authors
- Vanderauwera, S., Suzuki, N., Miller, G., van de Cotte, B., Morsa, S., Ravanat, J.-L., Hegie, A., Triantaphylidès, C., Shulaev, V., Van Montagu, M. C. E., Van Breusegem, F., & Mittler, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-01-10
- Volume
- 108
- Issue
- 4
- Pages
- 1711-1716
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1981479374
- Cited by
- 229
- References
- 6
- FWCI
- 17.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vanderauwera, S., Suzuki, N., Miller, G., van de Cotte, B., Morsa, S., Ravanat, J.-L., Hegie, A., Triantaphylidès, C., Shulaev, V., Van Montagu, M. C. E., Van Breusegem, F., & Mittler, R. (2011). Extranuclear protection of chromosomal DNA from oxidative stress. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1018359108
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
