The DNA Damage Response: Ten Years After

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

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Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

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Cell Cycle Checkpoints: Preventing an Identity Crisis

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PCNA, the Maestro of the Replication Fork

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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

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RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

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Molecular mechanism of nucleotide excision repair

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Histone acetyltransferase complexes: one size doesn't fit all

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RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

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Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

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TopBP1 Activates the ATR-ATRIP Complex

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Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

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Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

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p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage

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Regulation of monoubiquitinated PCNA by DUB autocleavage

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A Ubiquitin Mutant with Specific Defects in DNA Repair and Multiubiquitination

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

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Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

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γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes

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Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cellsPreprint

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Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

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Homologous repair of DNA damage and tumorigenesis:the BRCA connection

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Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites.Preprint

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UBA domains of DNA damage-inducible proteins interact with ubiquitin.

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Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11

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The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function.

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The Chk2 protein kinase

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Adaptation of a DNA Replication Checkpoint Response Depends upon Inactivation of Claspin by the Polo-like Kinase

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The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint

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One Ring to Rule a Superfamily of E3 Ubiquitin Ligases

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DNA Damage Response as an Anti-Cancer Barrier: Damage Threshold and the Concept of 'Conditional Haploinsufficiency'

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Interplay of replication checkpoints and repair proteins at stalled replication forks

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Arrested replication fork processing: Interplay between checkpoints and recombination

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Stabilizers and Destabilizers Controlling Cell Cycle Oscillators

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Ubiquitin proteasome system (UPS): what can chromatin do for you?

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Emerging links between the biological clock and the DNA damage response

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The Fanconi Family Adds a Fraternal Twin

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A Touching Response to Damage

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Checkpoint and Coordinated Cellular Responses to DNA Damage

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DNA-Damage Control: Claspin Destruction Turns off the Checkpoint

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Hallmarks of Cancer: The Next Generation

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The DNA-damage response in human biology and disease

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The DNA Damage Response: Making It Safe to Play with Knives

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DNA damage, aging, and Cancer

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Mechanisms of DNA damage, repair, and mutagenesis

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Principles of cancer therapy: oncogene and non-oncogene addiction

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Cellular Stress Responses: Cell Survival and Cell Death

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Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

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DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

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Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

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Transcription-coupled DNA repair: two decades of progress and surprises

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Nonproteolytic Functions of Ubiquitin in Cell Signaling

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Effects of Ionizing Radiation on Biological Molecules—Mechanisms of Damage and Emerging Methods of Detection

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Radiation-induced bystander signalling in cancer therapy

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Mechanisms of Multidrug Resistance in Cancer

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Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

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53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

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Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

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Therapeutic opportunities within the DNA damage response

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The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

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A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

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Comparative Genomics and Molecular Dynamics of DNA Repeats in Eukaryotes

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ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

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A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

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Oxidative stress and pulmonary fibrosis

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The cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

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Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

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DNA Damage ResponsePreprint

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The p53 network: cellular and systemic DNA damage responses in aging and Cancer

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Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

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The MRN complex in double‐strand break repair and telomere maintenance

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Analysis of protein dynamics at active, stalled, and collapsed replication forksPreprint

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Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis

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DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing

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Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

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WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

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The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint

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Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

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Regulation of DNA‐damage responses and cell‐cycle progression by the chromatin remodelling factor CHD4

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Human Papillomaviruses Activate the ATM DNA Damage Pathway for Viral Genome Amplification upon Differentiation

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Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair

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Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

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DNA damage and ageing: new-age ideas for an age-old problem

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Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography

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Plant flavonoids in cancer chemoprevention: role in genome stability

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A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

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Screen for DNA‐damage‐responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells

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Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

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Assembly and function of DNA double-strand break repair foci in mammalian cells

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A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

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Checkpoint kinase 1 in DNA damage response and cell cycle regulation

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DNA repair deficiency and neurological disease

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Function of BRCA1 in the DNA Damage Response Is Mediated by ADP-Ribosylation

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DNA polymerases and human disease

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Mapping the Genetic Landscape of Human Cells

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Molecular Cell Perspective The DNA Damage Response: Ten Years After

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DNA Damage Response and Metabolic Reprogramming in Health and Disease

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