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Subtype and pathway specific responses to anticancer compounds in breast cancer
Open accessAbstract
Breast cancers are comprised of molecularly distinct subtypes that may respond differently to pathway-targeted therapies now under development. Collections of breast cancer cell lines mirror many of the molecular subtypes and pathways found in tumors, suggesting that treatment of cell lines with candidate therapeutic compounds can guide identification of associations between molecular subtypes, pathways, and drug response. In a test of 77 therapeutic compounds, nearly all drugs showed differential responses across these cell lines, and approximately one third showed subtype-, pathway-, and/or genomic aberration-specific responses. These observations suggest mechanisms of response and resistance and may inform efforts to develop molecular assays that predict clinical response.
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The Cancer Genome Atlas Research Network, Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Shmulevich, I., Sander, C., & Stuart, J. M. (2013) · Nature Genetics · doi:10.1038/ng.2764 · Cited by 9,092
Self-citationReprogramming of fatty acid metabolism in cancer
Koundouros, N., & Poulogiannis, G. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0650-z · Cited by 1,614
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“Comprehensive cancer cell line panels screened for sensitivity to pan-PI3K, p110a-specific, and AKT inhibitors have consistently shown preferential activity of these drugs against HER2-amplified breast cancer lines (Heiser et al., 2012; O’Brien et al., 2010).”
BackgroundSadanandam, A., Lyssiotis, C. A., Homicsko, K., Collisson, E. A., Gibb, W. J., Wullschleger, S., Ostos, L. C. G., Lannon, W. A., Grotzinger, C., Del Rio, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3175 · Cited by 960
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Metadata
- Authors
- Heiser, L. M., Sadanandam, A., Kuo, W.-L., Benz, S. C., Goldstein, T. C., Ng, S., Gibb, W. J., Wang, N. J., Ziyad, S., Tong, F., Bayani, N., Hu, Z., Billig, J. I., Dueregger, A., Lewis, S., Jakkula, L., Korkola, J. E., Durinck, S., Pepin, F., Guan, Y., Purdom, E., Neuvial, P., Bengtsson, H., Wood, K. W., Smith, P. G., Vassilev, L. T., Hennessy, B. T., Greshock, J., Bachman, K. E., Hardwicke, M. A., Park, J. W., Marton, L. J., Wolf, D. M., Collisson, E. A., Neve, R. M., Mills, G. B., Speed, T. P., Feiler, H. S., Wooster, R. F., Haussler, D., Stuart, J. M., Gray, J. W., & Spellman, P. T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-10-14
- Volume
- 109
- Issue
- 8
- Pages
- 2724-2729
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2162946128
- Cited by
- 475
- References
- 5
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Heiser, L. M., Sadanandam, A., Kuo, W.-L., Benz, S. C., Goldstein, T. C., Ng, S., Gibb, W. J., Wang, N. J., Ziyad, S., Tong, F., Bayani, N., Hu, Z., Billig, J. I., Dueregger, A., Lewis, S., Jakkula, L., Korkola, J. E., Durinck, S., Pepin, F., . . . Spellman, P. T. (2012). Subtype and pathway specific responses to anticancer compounds in breast cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1018854108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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