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The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative
Open accessAbstract
Reactive oxygen species induce the expression of detoxification and repair genes critical for life in an aerobic environment. Bacterial factors that sense reactive oxygen species use either thiol-disulfide exchange reactions (OxyR, RsrA) or redox labile 2Fe–2S clusters (SoxR). We demonstrate that the reduced form of Bacillus subtilis OhrR binds cooperatively to two adjacent inverted repeat sequences in the ohrA control region and thereby represses transcription. In the presence of organic hydroperoxides, OhrR is inactivated by the reversible oxidation of a single conserved cysteine residue to the corresponding cysteine-sulfenic acid, and perhaps to higher oxidation states.
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Cited by
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D'Autréaux, B., & Toledano, M. B. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2256 · Cited by 3,642
Hydrogen peroxide sensing and signaling
Veal, E. A., Day, A. M., & Morgan, B. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.016 · Cited by 1,604
Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches
Paulsen, C. E., & Carroll, K. S. (2010) · ACS Chemical Biology · doi:10.1021/cb900258z · Cited by 476
Sulfenic acid chemistry, detection and cellular lifetime
Gupta, V., & Carroll, K. S. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.05.040 · Cited by 427
Green, J., & Paget, M. S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro1022 · Cited by 410
Metadata
- Authors
- Fuangthong, M., & Helmann, J. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-04-30
- Volume
- 99
- Issue
- 10
- Pages
- 6690-6695
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2107553219
- Cited by
- 230
- References
- 0
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Fuangthong, M., & Helmann, J. D. (2002). The OhrR repressor senses organic hydroperoxides by reversible formation of a cysteine-sulfenic acid derivative. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.102483199
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