Cited by 3,642Redox biology and oxidative stressGenetics, Aging, and Longevity in Model OrganismsAntioxidant Activity and Oxidative Stress

ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis

D'Autréaux, Benoît, Toledano, Michel B.·2007·Nature Reviews Molecular Cell Biology

Abstract

Reactive oxygen species (ROS) have been shown to be toxic but also function as signalling molecules. This biological paradox underlies mechanisms that are important for the integrity and fitness of living organisms and their ageing. The pathways that regulate ROS homeostasis are crucial for mitigating the toxicity of ROS and provide strong evidence about specificity in ROS signalling. By taking advantage of the chemistry of ROS, highly specific mechanisms have evolved that form the basis of oxidant scavenging and ROS signalling systems.

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Crossref · 10.1038/nrm2256

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Authors
D'Autréaux, B., & Toledano, M. B.
Venue
Nature Reviews Molecular Cell Biology
Published
2007-10
Volume
8
Issue
10
Pages
813-824
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W2102472842
Cited by
3,642
References
133
Citations by year
2026: 155 · 2025: 214 · 2024: 248 · 2023: 266 · 2022: 264 · 2021: 299 · 2020: 184 · 2019: 238 · 2018: 217 · 2017: 213 · 2016: 224 · 2015: 188 · 2014: 204 · 2013: 184 · 2012: 166
FWCI
6.36
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
reactive oxygen species, ROS signalling, ROS homeostasis, oxidative stress, aging, prokaryotes, mammals
MeSH terms
Animals, Homeostasis, Humans, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species

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