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Cited by 288

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Characterization of a canine homolog of hepatitis C virus

Open access
Kapoor, Amit, Simmonds, Peter, Gerold, Gisa, Qaisar, Natasha, Jain, Komal, Henriquez, Jose A., Firth, Cadhla, Hirschberg, David L., Rice, Charles M., Shields, Shelly, Lipkin, W. Ian·2011·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1101794108
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Abstract

An estimated 3% of the world's population is chronically infected with hepatitis C virus (HCV). Although HCV was discovered more than 20 y ago, its origin remains obscure largely because no closely related animal virus homolog has been identified; furthermore, efforts to understand HCV pathogenesis have been hampered by the absence of animal models other than chimpanzees for human disease. Here we report the identification in domestic dogs of a nonprimate hepacivirus. Comparative phylogenetic analysis of the canine hepacivirus (CHV) confirmed it to be the most genetically similar animal virus homolog of HCV. Bayesian Markov chains Monte Carlo and associated time to most recent common ancestor analyses suggest a mean recent divergence time of CHV and HCV clades within the past 500–1,000 y, well after the domestication of canines. The discovery of CHV may provide new insights into the origin and evolution of HCV and a tractable model system with which to probe the pathogenesis, prevention, and treatment of diseases caused by hepacivirus infection.

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Metadata

Authors
Kapoor, A., Simmonds, P., Gerold, G., Qaisar, N., Jain, K., Henriquez, J. A., Firth, C., Hirschberg, D. L., Rice, C. M., Shields, S., & Lipkin, W. I.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2011-05-24
Volume
108
Issue
28
Pages
11608-11613
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1101794108
OpenAlex
W2037999529
Cited by
288
References
39
FWCI
19.96
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Characterization of a canine homolog of hepatitis C virus. https://app.cochat.ai/papers/10.1073/pnas.1101794108
The paper
Kapoor, A., Simmonds, P., Gerold, G., Qaisar, N., Jain, K., Henriquez, J. A., Firth, C., Hirschberg, D. L., Rice, C. M., Shields, S., & Lipkin, W. I. (2011). Characterization of a canine homolog of hepatitis C virus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1101794108

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.