The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Direct conversion of human fibroblasts to dopaminergic neurons
Open accessAbstract
Recent reports demonstrate that somatic mouse cells can be directly converted to other mature cell types by using combined expression of defined factors. Here we show that the same strategy can be applied to human embryonic and postnatal fibroblasts. By overexpression of the transcription factors Ascl1, Brn2, and Myt1l, human fibroblasts were efficiently converted to functional neurons. We also demonstrate that the converted neurons can be directed toward distinct functional neurotransmitter phenotypes when the appropriate transcriptional cues are provided together with the three conversion factors. By combining expression of the three conversion factors with expression of two genes involved in dopamine neuron generation, Lmx1a and FoxA2 , we could direct the phenotype of the converted cells toward dopaminergic neurons. Such subtype-specific induced neurons derived from human somatic cells could be valuable for disease modeling and cell replacement therapy.
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Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
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Direct conversion of fibroblasts to functional neurons by defined factors
Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M. (2010) · Nature · doi:10.1038/nature08797 · Cited by 3,017
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
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Induced pluripotent stem cells from a spinal muscular atrophy patient
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Identification of intrinsic determinants of midbrain dopamine neurons
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Rapid single-step induction of functional neurons from human pluripotent stem cells
Zhang, Y., Pak, C., Han, Y., Ahlenius, H., Zhang, Z., Chanda, S., Marro, S., Patzke, C., Acuna, C., Covy, J., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.029 · Cited by 1,644
Jo, J., Xiao, Y., Sun, A. X., Cukuroglu, E., Tran, H.-D., Göke, J., Tan, Z. Y., Saw, T. Y., Tan, C.-P., Lokman, H., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.07.005 · Cited by 861
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Shi, Y., Lin, S., Staats, K. A., Li, Y., Chang, W.-H., Hung, S.-T., Hendricks, E., Linares, G. R., Wang, Y., Son, E. Y., et al. (2018) · Nature Medicine · doi:10.1038/nm.4490 · Cited by 566
Direct conversion of fibroblasts into stably expandable neural stem cells
Thier, M., Wörsdörfer, P., Lakes, Y. B., Gorris, R., Herms, S., Opitz, T., Seiferling, D., Quandel, T., Hoffmann, P., Nöthen, M. M., et al. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.03.003 · Cited by 447
Metadata
- Authors
- Pfisterer, U., Kirkeby, A., Torper, O., Wood, J., Nelander, J., Dufour, A., Björklund, A., Lindvall, O., Jakobsson, J., & Parmar, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2011-06-06
- Volume
- 108
- Issue
- 25
- Pages
- 10343-10348
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2114206069
- Cited by
- 744
- References
- 6
- FWCI
- 32.33
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Direct conversion of human fibroblasts to dopaminergic neurons. https://app.cochat.ai/papers/10.1073/pnas.1105135108
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- Pfisterer, U., Kirkeby, A., Torper, O., Wood, J., Nelander, J., Dufour, A., Björklund, A., Lindvall, O., Jakobsson, J., & Parmar, M. (2011). Direct conversion of human fibroblasts to dopaminergic neurons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1105135108
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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