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Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein
Open accessAbstract
Certain types of human papillomaviruses (HPVs) are closely linked to the development of human cancers. Herein, it is shown that intracellular targeting of the HPV16 E6 oncoprotein by E6-binding peptide aptamers resulted in the apoptotic elimination of HPV16-positive cancer cells, whereas HPV-negative cells were not affected. These results provide direct experimental evidence that the HPV E6 oncoprotein has antiapoptotic activity in HPV-positive tumor cells that is required for their survival. The E6-targeting molecules identified herein have implications for the development of therapeutic strategies for the treatment of HPV-associated dysplasias and cancers.
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Cited by
Hershko, A., Ciechanover, A., & Varshavsky, A. (2000) · Nature Medicine · doi:10.1038/80384 · Cited by 649
Butz, K., Ristriani, T., Hengstermann, A., Denk, C., Scheffner, M., & Hoppe-Seyler, F. (2003) · Oncogene · doi:10.1038/sj.onc.1206894 · Cited by 283
Self-citationNew Approaches and Therapeutics Targeting Apoptosis in Disease
Fischer, U., & Schulze-Osthoff, K. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.6 · Cited by 257
Honegger, A., Schilling, D., Bastian, S., Sponagel, J., Kuryshev, V., Sültmann, H., Scheffner, M., Hoppe-Seyler, K., & Hoppe-Seyler, F. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004712 · Cited by 222
Self-citationHuman papillomaviruses, cervical cancer and cell polarity
Thomas, M., Narayan, N., Pim, D., Tomaić, V, Massimi, P., Nagasaka, K., Kranjec, C., Gammoh, N., & Banks, L. (2008) · Oncogene · doi:10.1038/onc.2008.351 · Cited by 163
Metadata
- Authors
- Butz, K., Denk, C., Ullmann, A., Scheffner, M., & Hoppe-Seyler, F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-05-30
- Volume
- 97
- Issue
- 12
- Pages
- 6693-6697
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1997161295
- Cited by
- 241
- References
- 0
- FWCI
- 13.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Butz, K., Denk, C., Ullmann, A., Scheffner, M., & Hoppe-Seyler, F. (2000). Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.110538897
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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