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Mitochondrial matrix Ca 2 + as an intrinsic signal regulating mitochondrial motility in axons
Open accessAbstract
The proper distribution of mitochondria is particularly vital for neurons because of their polarized structure and high energy demand. Mitochondria in axons constantly move in response to physiological needs, but signals that regulate mitochondrial movement are not well understood. Aside from producing ATP, Ca 2+ buffering is another main function of mitochondria. Activities of many enzymes in mitochondria are also Ca 2+ -dependent, suggesting that intramitochondrial Ca 2+ concentration is important for mitochondrial functions. Here, we report that mitochondrial motility in axons is actively regulated by mitochondrial matrix Ca 2+ . Ca 2+ entry through the mitochondrial Ca 2+ uniporter modulates mitochondrial transport, and mitochondrial Ca 2+ content correlates inversely with the speed of mitochondrial movement. Furthermore, the miro1 protein plays a role in Ca 2+ uptake into the mitochondria, which subsequently affects mitochondrial movement.
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“it has been largely described that Ca2+ is a key regulator of mitochondria motility and docking44–49,107.”
From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [48]
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Metadata
- Authors
- Chang, K. T., Niescier, R. F., & Min, K.-T.
- Affiliations
- University of Southern California (US)
- Indiana University Bloomington (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2011-08-29
- Volume
- 108
- Issue
- 37
- Pages
- 15456-15461
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3174631
- OpenAlex
- W1998654006
- Cited by
- 153
- References
- 33
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 13 · 2023: 11 · 2022: 13 · 2021: 14 · 2020: 10 · 2019: 12 · 2018: 8 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 12 · 2013: 6 · 2012: 8
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (K99NS052524, NS052524, R00NS052524)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- mitochondrial motility, axons, mitochondrial matrix calcium, mitochondrial calcium uniporter, calcium uptake, Miro1, mitochondrial transport, calcium buffering, neuronal energy metabolism, calcium-dependent enzyme activity
- MeSH terms
- Animals, Axons, Calcium, Humans, Mitochondria, Movement, Mutation, Calcium Channels, Calcium Signaling, EF Hand Motifs, Mitochondrial Proteins, Mice
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