Mitochondria in neuroplasticity and neurological disorders
Open accessAbstract
Mitochondrial electron transport generates the ATP that is essential for the excitability and survival of neurons, and the protein phosphorylation reactions that mediate synaptic signaling and related long-term changes in neuronal structure and function. Mitochondria are highly dynamic organelles that divide, fuse, and move purposefully within axons and dendrites. Major functions of mitochondria in neurons include the regulation of Ca(2+) and redox signaling, developmental and synaptic plasticity, and the arbitration of cell survival and death. The importance of mitochondria in neurons is evident in the neurological phenotypes in rare diseases caused by mutations in mitochondrial genes. Mitochondria-mediated oxidative stress, perturbed Ca(2+) homeostasis, and apoptosis may also contribute to the pathogenesis of prominent neurological diseases including Alzheimer's, Parkinson's, and Huntington's diseases; stroke; amyotrophic lateral sclerosis; and psychiatric disorders. Advances in understanding the molecular and cell biology of mitochondria are leading to novel approaches for the prevention and treatment of neurological disorders.
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In neurons, mitochondria generate ATP through oxidative phosphorylation in order to sustain synaptic transmission and cell maintenance/repair.
“In neurons, mitochondria generate ATP through oxidative phosphorylation in order to sustain synaptic transmission and cell maintenance/repair.73,75”
From Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex (2026) · cites this paper as [75]
The Structure and Regulatory Systems of Mitochondria section describes ATP production by the electron transport chain, and Mitochondria in Synaptic Plasticity links mitochondrial ATP to synaptic function. The Abstract says this ATP is essential for neuronal survival, which supports cell maintenance, but the passages do not establish a role in cell repair. Page numbers are unavailable in our copy. (LLM, conf=0.84)
Experimental — accuracy not yet measuredMitochondrial dysfunction is a known hallmark of the aging brain and neurodegenerative disorders.
“Mitochondrial dysfunction is a known hallmark of the aging brain73,74 and neurodegenerative disorders.75,76,77”
From Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex (2026) · cites this paper as [75]
Mitochondria generate ATP for neuronal activities including neurotransmission and Ca2+ homeostasis and provide signals regulating nuclear-mitochondrial communication and neuronal survival/death.
“Mitochondria generate ATP to support neuronal activities including neurotransmission and Ca2+ homeostasis and are a source of signals that regulate nuclear-mitochondrial communication and even the arbitration of neuronal survival and death (Mattson et al., 2008).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Mattson et al., 2008
Mitochondria from animal and post-mortem human brain tissues show age-dependent increases in functional heterogeneity, oxidative damage, reduced ETC function, disrupted membrane potential, impaired Ca2+ handling, and/or accumulation of dysfunctional mitochondria.
“Mitochondria isolated from animal and post-mortem human brain tissues show an age-dependent rise in mitochondrial functional heterogeneity, increased oxidative damage, reduced function of the ETC, disrupted membrane potential, impaired Ca2+ handling, and/or an accumulation of dysfunctional mitochondria (Lin and Beal, 2006; Mattson et al., 2008; Sorrentino et al., 2017).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Mattson et al., 2008
On the basis of evidence from post-mortem brain tissues from Alzheimer's disease patients and different AD mouse models, damaged mitochondria and increased oxidative stress are common features of Alzheimer's disease.
“On the basis of evidence from post-mortem brain tissues from AD patients as well as different AD mouse models, damaged mitochondria and increased oxidative stress are common features of AD (Lin and Beal, 2006; Mattson et al., 2008).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Mattson et al., 2008
Brain mitochondrial dysfunction and the resulting bioenergetic disruption are fundamental to the injury cascade of traumatic brain injury (TBI).
“Brain mitochondrial dysfunction and the resulting bioenergetic disruption are fundamental to the injury cascade of TBI.”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [115]
Mitochondria are crucial to energy production, calcium homeostasis, free radical production, neurotransmitter synthesis, and apoptosis in neurons and glia.
“Mitochondria are crucial to energy production, as well as calcium homeostasis, free radical production, neurotransmitter synthesis, and apoptosis in neurons and glia.”
From Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know (2019) · cites this paper as [115]
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Cites
Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works
α-Synuclein Locus Triplication Causes Parkinson's Disease
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383 · see citing works
Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
Miyawaki, A., Llopis, J. L., Heim, R., McCaffery, J. M., Adams, J. A., Ikura, M., & Tsien, R. Y. (1997) · Nature · doi:10.1038/42264 · Cited by 3,250 · see citing works
Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., & Nagata, S. (1998) · Nature · doi:10.1038/34112 · Cited by 3,181 · see citing works
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works
Self-citationTDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
Sreedharan, J., Blair, I. P., Tripathi, V. B., Hu, X., Vance, C., Rogelj, B., Ackerley, S., Durnall, J. C., Williams, K. L., Buratti, E., et al. (2008) · Science · doi:10.1126/science.1154584 · Cited by 2,630 · see citing works
Walker, F. O. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60111-1 · Cited by 2,623 · see citing works
A Century of Alzheimer's Disease
Goedert, M., & Spillantini, M. G. (2006) · Science · doi:10.1126/science.1132814 · Cited by 2,106 · see citing works
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
Kuida, K., Zheng, T. S., Na, S., Kuan, C.-Y., Yang, D., Karasuyama, H., RAKIC, P. T., & Flavell, R. A. (1996) · Nature · doi:10.1038/384368a0 · Cited by 1,881 · see citing works
Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
Yu, S.-W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2002) · Science · doi:10.1126/science.1072221 · Cited by 1,826 · see citing works
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788 · see citing works
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Verdugo, J. M. G., Armanini, M., Ryan, A., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)80886-7 · Cited by 1,722 · see citing works
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705 · see citing works
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
Li, Z., Okamoto, K.-I., Hayashi, Y., & Sheng, M. (2004) · Cell · doi:10.1016/j.cell.2004.11.003 · Cited by 1,498 · see citing works
Lindsten, T., Ross, A. J., King, A., Zong, W.-X., Rathmell, J. C., Shiels, H. A., Ulrich, E., Waymire, K. G., Mahar, P., Frauwirth, K., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00136-2 · Cited by 1,489 · see citing works
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
Boillée, S., Velde, C. V., & Cleveland, D. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.018 · Cited by 1,426 · see citing works
Mitochondrial abnormalities in Alzheimer's disease
Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works
ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease
Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science · doi:10.1126/science.1091230 · Cited by 1,303 · see citing works
Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo
Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kägi, D., Khoo, W., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81477-4 · Cited by 1,284 · see citing works
Mitochondrial pathology and apoptotic muscle degeneration in <i>Drosophila parkin</i> mutants
Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., & Pallanck, L. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737556100 · Cited by 1,203 · see citing works
The axonal transport of mitochondria
Saxton, W. M., & Hollenbeck, P. J. (2012) · Journal of Cell Science · doi:10.1242/jcs.053850 · Cited by 1,198 · see citing works
Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
Yoshida, H., Kong, Y., Yoshida, R., Elia, A., Hakem, A., Hakem, R., Penninger, J. M., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81733-x · Cited by 1,138 · see citing works
Cutler, R. G., Kelly, J., Storie, K., Pedersen, W. A., Tammara, A., Hatanpaa, K. J., Troncoso, J. C., & Mattson, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305799101 · Cited by 1,135 · see citing works
Self-citationCanet-Aviles, R., Wilson, M. A., Miller, D. W., Ahmad, R., McLendon, C., Bandyopadhyay, S., Baptista, M. J., Ringe, D., Petsko, G. A., & Cookson, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402959101 · Cited by 1,115 · see citing works
Manczak, M., Anekonda, T. S., Henson, E., Park, B. S., Quinn, J., & Reddy, P. H. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl066 · Cited by 1,104 · see citing works
The apoptosome: Signalling platform of cell death
Riedl, S. J., & Salvesen, G. S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2153 · Cited by 1,097 · see citing works
Devi, L., Raghavendran, V., Prabhu, B. M., Avadhani, N. G., & Anandatheerthavarada, H. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710012200 · Cited by 1,087 · see citing works
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
Panov, A. V., Gutekunst, C.-A., Leavitt, B. R., Hayden, M. R., Burke, J. R., Strittmatter, W. J., & Greenamyre, J. T. (2002) · Nature Neuroscience · doi:10.1038/nn884 · Cited by 1,030 · see citing works
Cui, L., Jeong, H., Borovecki, F., Parkhurst, C. N., Tanese, N., & Krainc, D. (2006) · Cell · doi:10.1016/j.cell.2006.09.015 · Cited by 1,012 · see citing works
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
Yin, X.-M., Wang, K., Gross, A., Zhao, Y., Zinkel, S., Klocke, B., Roth, K. A., & Korsmeyer, S. J. (1999) · Nature · doi:10.1038/23730 · Cited by 1,004 · see citing works
Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice
Palacino, J. J., Sagi, D., Goldberg, M. S., Krauss, S., Motz, C., Wacker, M., Klose, J., & Shen, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401135200 · Cited by 995 · see citing works
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
Bezprozvanny, I., & Mattson, M. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.005 · Cited by 938 · see citing works
Self-citationStructural Basis of Mitochondrial Tethering by Mitofusin Complexes
Koshiba, T., Detmer, S. A., Kaiser, J. T., Chen, H., McCaffery, J. M., & Chan, D. C. (2004) · Science · doi:10.1126/science.1099793 · Cited by 910 · see citing works
The PINK1/Parkin pathway regulates mitochondrial morphology
Poole, A. C., Thomas, R. E., Andrews, L. A., McBride, H. M., Whitworth, A. J., & Pallanck, L. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709336105 · Cited by 885 · see citing works
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
Schapira, A. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70327-7 · Cited by 883 · see citing works
Keller, J. N., Kindy, M. S., Holtsberg, F. W., St. Clair, D. K., Yen, H.-C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., & Mattson, M. P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00687.1998 · Cited by 863 · see citing works
Self-citationVerstreken, P., Ly, C. V., Venken, K. J. T., Koh, T.-W., Zhou, Y., & Bellen, H. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.018 · Cited by 841 · see citing works
Schinzel, A. C., Takeuchi, O., Huang, Z., Fisher, J. K., Zhou, Z., Rubens, J., Hetz, C., Danial, N. N., Moskowitz, M. A., & Korsmeyer, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505294102 · Cited by 820 · see citing works
Ancient Invasions: From Endosymbionts to Organelles
Dyall, S. D., Brown, M. T., & Johnson, P. J. (2004) · Science · doi:10.1126/science.1094884 · Cited by 819 · see citing works
Yang, Y., Gehrke, S., Imai, Y., Huang, Z., Ouyang, Y., Wang, J.-W., Yang, L., Beal, M. F., Vogel, H., & Lu, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602493103 · Cited by 798 · see citing works
The axonal transport of mitochondria
Hollenbeck, P. J., & Saxton, W. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02745 · Cited by 771 · see citing works
BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?
Lü, Y., Christian, K. M., & Lu, B. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.018 · Cited by 768 · see citing works
Keeney, P., Xie, J., Capaldi, R., & Bennett, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0984-06.2006 · Cited by 757 · see citing works
Kong, J., & Xu, Z. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03241.1998 · Cited by 723 · see citing works
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
Yu, S.-W., Andrabi, S. A., Wang, H., Kim, N. S., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606528103 · Cited by 718 · see citing works
α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress
Hsu, L. J., Sagara, Y., Arroyo, A., Rockenstein, E. M., Sisk, A., Mallory, M. E., Wong, J., Takenouchi, T., Hashimoto, M., & Masliah, E. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64553-1 · Cited by 716 · see citing works
Superoxide flashes in single mitochondria
Wang, W., Fang, H., Groom, L., Cheng, A., Zhang, W., Liu, J., Wang, X., Li, K., Han, P., Zheng, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.017 · Cited by 715 · see citing works
Self-citationFerrante, R. J., Kubilus, J. K., Lee, J.-H., Ryu, H., Beesen, A. A., Zucker, B., Smith, K., Kowall, N. W., Ratan, R. R., Luthi‐Carter, R., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09418.2003 · Cited by 694 · see citing works
Martin, L. J., Pan, Y., Price, A. C., Sterling, W., Copeland, N. G., Jenkins, N. A., Price, D. L., & Lee, M. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4308-05.2006 · Cited by 684 · see citing works
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis
Klivenyi, P., Ferrante, R. J., Matthews, R. T., Bogdanov, M. B., Klein, A. M., Andreassen, O. A., Mueller, G., Wermer, M., Kaddurah-Daouk, R., & Beal, M. F. (1999) · Nature Medicine · doi:10.1038/6568 · Cited by 682 · see citing works
Nitric oxide‐induced mitochondrial fission is regulated by dynamin‐related GTPases in neurons
Barsoum, M. J., Yuan, H., Gerencser, A. A., Liot, G., Kushnareva, Y., Gräber, S., Kovács, I., Lee, W. D., Waggoner, J., Cui, J., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601253 · Cited by 658 · see citing works
Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view
Twig, G., Hyde, B. B., & Shirihai, O. S. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.05.001 · Cited by 646 · see citing works
Axonal Transport of Mitochondria to Synapses Depends on Milton, a Novel Drosophila Protein
Stowers, R. S., Megeath, L. J., Górska‐Andrzejak, J., Meinertzhagen, I. A., & Schwarz, T. L. (2002) · Neuron · doi:10.1016/s0896-6273(02)01094-2 · Cited by 643 · see citing works
Origin and functional consequences of the complex I defect in Parkinson's disease
Swerdlow, R. H., Parks, J. K., Miller, S. W., Davis, R. E., Tuttle, J. B., Trimmer, P. A., Sheehan, J. P., Bennett, J. P., & Parker, W. D. (1996) · Annals of Neurology · doi:10.1002/ana.410400417 · Cited by 638 · see citing works
Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis
Beal, M. F., Ferrante, R. J., Browne, S. E., Matthews, R. T., Kowall, N. W., & Brown, R. H. (1997) · Annals of Neurology · doi:10.1002/ana.410420416 · Cited by 599 · see citing works
Kang, J.-S., Tian, J.-H., Pan, P.-Y., Zald, P., Li, C., Deng, C., & Sheng, Z.-H. (2008) · Cell · doi:10.1016/j.cell.2007.11.024 · Cited by 598 · see citing works
PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1
Pridgeon, J. W., Olzmann, J. A., Chin, L.-S., & Li, L. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050172 · Cited by 596 · see citing works
Weydt, P., Pineda, V. V., Torrence, A. E., Libby, R. T., Satterfield, T. F., Lazarowski, E. R., Gilbert, M. L., Morton, G. J., Bammler, T. K., Strand, A. D., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.004 · Cited by 562 · see citing works
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
Yang, Y., Ouyang, Y., Yang, L., Beal, M. F., McQuibban, G. A., Vogel, H. S., & Lu, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711845105 · Cited by 536 · see citing works
Mattiasson, G., Shamloo, M., Gido, G., Mathi, K., Tomasevic, G., Yi, S., Warden, C. H., Castilho, R. F., Melcher, T., Gonzalez-Zulueta, M., et al. (2003) · Nature Medicine · doi:10.1038/nm903 · Cited by 515 · see citing works
Choo, Y. S. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh162 · Cited by 515 · see citing works
Axonal mitochondrial transport and potential are correlated
Miller, K. E., & Sheetz, M. P. (2004) · Journal of Cell Science · doi:10.1242/jcs.01130 · Cited by 512 · see citing works
Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin
Exner, N., Treske, B., Paquet, D., Holmström, K. M., Schiesling, C., Gispert, S., Carballo‐Carbajal, I., Berg, D., Hoepken, H.-H., Gasser, T., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0719-07.2007 · Cited by 511 · see citing works
Pasinelli, P., Belford, M. E., Lennon, N. J., Bacskai, B. J., Hyman, B. T., Trotti, D., & Brown, R. H. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.021 · Cited by 506 · see citing works
Liu, J., Head, E., Gharib, A., Yuan, W., Ingersoll, R. T., Hagen, T. M., Cotman, C. W., & Ames, B. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261709299 · Cited by 504 · see citing works
Hashimoto, M., Rockenstein, E. M., Crews, L. A., & Masliah, E. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:4:1-2:21 · Cited by 498 · see citing works
Tanaka, Y. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.9.919 · Cited by 497 · see citing works
Iwamoto, K., Bundo, M., & Kato, T. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi022 · Cited by 496 · see citing works
p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington’s Disease
Bae, B.-I., Xu, H., Igarashi, S., Fujimuro, M., Agrawal, N., Taya, Y., Hayward, S. D., Moran, T. H., Montell, C., Ross, C. A., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.005 · Cited by 480 · see citing works
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
Andrés‐Mateos, E., Perier, C., Zhang, L., Blanchard-Fillion, B., Greco, T. M., Thomas, B., Ko, H. S., Sasaki, M., Ischiropoulos, H., Przedborski, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703219104 · Cited by 478 · see citing works
A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients
Maurer, I. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00112-3 · Cited by 475 · see citing works
A Hundred Years of Alzheimer's Disease Research
Hardy, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.016 · Cited by 467 · see citing works
Mitochondrial Involvement in Post-Tetanic Potentiation of Synaptic Transmission
Tang, Y.-G., & Zucker, R. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)81248-9 · Cited by 441 · see citing works
N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking
Orr, A. L., Li, S., Wang, C.-E., Li, H., Wang, J., Rong, J., Xu, X., Mastroberardino, P. G., Greenamyre, J. T., & Li, X. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0106-08.2008 · Cited by 429 · see citing works
Vos, K. J. D., Chapman, A. L., Tennant, M. E., Manser, C., Tudor, E. L., Lau, K., Brownlees, J., Ackerley, S., Shaw, P. J., McLoughlin, D. M., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm226 · Cited by 420 · see citing works
Videbech, P. (2000) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2000.101001011.x · Cited by 419 · see citing works
Zhang, L., Shimoji, M., Thomas, B., Moore, D. J., Yu, S.-W., Marupudi, N. I., Torp, R., Torgner, I. A., Ottersen, O. P., Dawson, T. M., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi211 · Cited by 418 · see citing works
DiFiglia, M., Sena‐Esteves, M., Chase, K. O., Sapp, E., Pfister, E., Sass, M., Yoder, J., Reeves, P., Pandey, R. K., Rajeev, K. G., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708285104 · Cited by 417 · see citing works
Billups, B., & Forsythe, I. D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05840.2002 · Cited by 414 · see citing works
Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.
Murphy, A. N., Bredesen, D. E., Cortopassi, G. A., Wang, E., & Fiskum, G. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9893 · Cited by 403 · see citing works
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
Darios, F. D. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg044 · Cited by 401 · see citing works
Gould, T. W., Buss, R. R., Vinsant, S. L., Prevette, D. M., Sun, W., Knudson, C. M., Milligan, C., & Oppenheim, R. W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2315-06.2006 · Cited by 397 · see citing works
Martins, L. M., Morrison, A., Klupsch, K., Fedele, V., Moisoi, N., Teismann, P., Abuin, A., Grau, E., Geppert, M., Livi, G. P., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9848-9862.2004 · Cited by 395 · see citing works
Pedersen, W. A., Fu, W., Keller, J. N., Markesbery, W. R., Appel, S. H., Smith, R. G., Kasarskis, E. J., & Mattson, M. P. (1998) · Annals of Neurology · doi:10.1002/ana.410440518 · Cited by 391 · see citing works
Self-citationCulmsee, C., & Mattson, M. P. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.149 · Cited by 388 · see citing works
Self-citationMiller, T. M., Moulder, K. L., Knudson, C. M., Creedon, D. J., Deshmukh, M., Korsmeyer, S. J., & Johnson, E. M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.1.205 · Cited by 383 · see citing works
Mitochondrial dynamics and division in budding yeast
Shaw, J. M., & Nunnari, J. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02246-2 · Cited by 375 · see citing works
Friberg, H., Ferrand-Drake, M., Bengtsson, F., Halestrap, A. P., & Wieloch, T. W. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05151.1998 · Cited by 366 · see citing works
Brouillet, E., Jacquard, C., Bizat, N., & Blum, D. L. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03515.x · Cited by 361 · see citing works
Hippocampal hypometabolism predicts cognitive decline from normal aging
Mosconi, L., De Santi, S., Li, J., Tsui, W. H., Li, Y., Boppana, M., Laska, E., Rusinek, H., & de Leon, M. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.008 · Cited by 360 · see citing works
Keller, J. N., Mark, R. J., Bruce‐Keller, A. J., Blanc, E. M., Rothstein, J. D., Uchida, K., Waeg, G., & Mattson, M. P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00065-1 · Cited by 358 · see citing works
Self-citationNeurohormetic phytochemicals: low-dose toxins that induce adaptive neuronal stress responses
Mattson, M. P., & Cheng, A. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.09.001 · Cited by 356 · see citing works
Self-citationDetmer, S. A., & Chan, D. C. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200611080 · Cited by 343 · see citing works
Evidence for Synaptic Apoptosis
Mattson, M. P., Keller, J. N., & Begley, J. G. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6863 · Cited by 340 · see citing works
Self-citationMoving Mitochondria: Establishing Distribution of an Essential Organelle
Frederick, R. L., & Shaw, J. M. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00644.x · Cited by 329 · see citing works
Cutler, R. G., Pedersen, W. A., Camandola, S., Rothstein, J. D., & Mattson, M. P. (2002) · Annals of Neurology · doi:10.1002/ana.10312 · Cited by 325 · see citing works
Self-citationTherapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines
Rogawski, M. A. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90005-5 · Cited by 318 · see citing works
Cassina, P., Cassina, A., Pehar, M., Castellanos, R., Gandelman, M., de León, A., Robinson, K. M., Mason, R. P., Beckman, J. S., Barbeito, L., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5308-07.2008 · Cited by 310 · see citing works
Cheng, A., Wang, S., Cai, J., Rao, M. S., & Mattson, M. P. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00120-9 · Cited by 310 · see citing works
Self-citationMPTP mechanisms of neurotoxicity and their implications for Parkinson's disease
Gerlach, M., Riederer, P. F., Przuntek, H., & Youdim, M. B. H. (1991) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(91)90073-q · Cited by 307 · see citing works
Mitochondrial involvement in psychiatric disorders
Shao, L., Martin, M. V., Watson, S. J., Schatzberg, A. F., Akil, H., Myers, R., Jones, E. G., Bunney, W. E., & Vawter, M. P. (2008) · Annals of Medicine · doi:10.1080/07853890801923753 · Cited by 303 · see citing works
Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport
Pigino, G. F., Morfini, G. A., Pelsman, A., Mattson, M. P., Brady, S. T., & Busciglio, J. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04499.2003 · Cited by 300 · see citing works
Self-citationEnergy metabolism in mammalian brain during development
Erecińska, M., Cherian, S., & Silver, I. A. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.003 · Cited by 299 · see citing works
Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons
Chang, D. T. W., Rintoul, G. L., Pandipati, S., & Reynolds, I. J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.007 · Cited by 299 · see citing works
Nerve Growth Factor Signaling Regulates Motility and Docking of Axonal Mitochondria
Chada, S. R., & Hollenbeck, P. J. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.027 · Cited by 296 · see citing works
Wang, H., Yu, S.-W., Koh, D. W., Lew, J., Coombs, C. M., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3461-04.2004 · Cited by 282 · see citing works
Hao, Z., Duncan, G. S., Chang, C., Elia, A., Fang, M., Wakeham, A. C., Okada, H., Calzascia, T., Jang, Y., You-Ten, A. J., et al. (2005) · Cell · doi:10.1016/j.cell.2005.03.016 · Cited by 278 · see citing works
Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria
Velde, C. V., Miller, T. M., Cashman, N. R., & Cleveland, D. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712209105 · Cited by 276 · see citing works
Gardner, A. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00067-8 · Cited by 272 · see citing works
Cybrids in Alzheimer's disease: a cellular model of the disease?
Swerdlow, R. H., Parks, J. K., Cassarino, D. S., Maguire, D. J., Maguire, R. S., Bennett, J. P., Davis, R. E., & Parker, W. D. (1997) · Neurology · doi:10.1212/wnl.49.4.918 · Cited by 272 · see citing works
Kruman, I. I., Pedersen, W. A., Springer, J. E., & Mattson, M. P. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7190 · Cited by 268 · see citing works
Self-citationMattson, M. P., Maudsley, S. R., & Martin, B. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.08.001 · Cited by 266 · see citing works
Self-citationEndophilin B1 is required for the maintenance of mitochondrial morphology
Karbowski, M., Jeong, S., & Youle, R. J. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200407046 · Cited by 264 · see citing works
Sources and Targets of Reactive Oxygen Species in Synaptic Plasticity and Memory
Kishida, K. T., & Klann, E. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.233 · Cited by 264 · see citing works
Cybrids in Alzheimer's disease: A cellular model of the disease?
Swerdlow, R. H., & Parker, D. W. (1998) · Neurology · doi:10.1212/wnl.51.1.326-a · Cited by 260 · see citing works
Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials
Ferri, A., Cozzolino, M., Crosio, C., Nencini, M., Casciati, A., Gralla, E. B., Rotilio, G., Valentine, J. S., & Carrı̀, M. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605814103 · Cited by 259 · see citing works
Ved, R., Saha, S., Westlund, B., Perier, C., Griffin, L. B., Sluder, A. E., Hoener, M. C., Rodrigues, C. M. P., Alfonso, A., Steer, C. J., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505910200 · Cited by 256 · see citing works
Nicastrin, Presenilin, APH-1, and PEN-2 Form Active γ-Secretase Complexes in Mitochondria
Hansson, C. A., Frykman, S., Farmery, M. R., Tjernberg, L. O., Nilsberth, C., Pursglove, S. E., Ito, A., Winblad, B., Cowburn, R. F., Thyberg, J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404500200 · Cited by 256 · see citing works
Genetics of familial and sporadic amyotrophic lateral sclerosis
Gros‐Louis, F., Gaspar, C., & Rouleau, G. A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.01.004 · Cited by 256 · see citing works
Esposito, L., Raber, J., Kekonius, L., Yan, F., Yu, G.-Q., Bien-Ly, N., Puoliväli, J., Scearce-Levie, K., Masliah, E., & Mucke, L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0482-06.2006 · Cited by 254 · see citing works
BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia
Plesnila, N., Zinkel, S. S., Le, D. A., Amin‐Hanjani, S., Wu, Y., Qiu, J., Chiarugi, A., Thomas, S. S., Kohane, D. S., Korsmeyer, S. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261323298 · Cited by 253 · see citing works
Mitochondrial Ca2+ as a key regulator of cell life and death
Giacomello, M., Drago, I., Pizzo, P., & Pozzan, T. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402147 · Cited by 249 · see citing works
Sources and Targets of Reactive Oxygen Species in Synaptic Plasticity and Memory
Kishida, K. T., & Klann, E. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.ft-8 · Cited by 245 · see citing works
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress
Moore, D. J., Zhang, L., Troncoso, J. C., Lee, M. K., Hattori, N., Mizuno, Y., Dawson, T. M., & Dawson, V. L. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi007 · Cited by 245 · see citing works
The mitochondrial protein MTP18 contributes to mitochondrial fission in mammalian cells
Tondera, D., Czauderna, F., Paulick, K., Schwarzer, R., Kaufmann, J., & Santel, A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02415 · Cited by 239 · see citing works
Bioenergetic approaches for neuroprotection in Parkinson's disease
Beal, M. F. (2003) · Annals of Neurology · doi:10.1002/ana.10479 · Cited by 236 · see citing works
Liu, D., Lu, C., Wan, R., Auyeung, W. W., & Mattson, M. P. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200204000-00007 · Cited by 212 · see citing works
Self-citationDrosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction
Park, J., Kim, S. Y., Cha, G., Lee, S. B., Kim, S., & Chung, J. (2005) · Gene · doi:10.1016/j.gene.2005.06.040 · Cited by 211 · see citing works
Review of the Literature on Major Mental Disorders in Adult Patients With Mitochondrial Diseases
Fattal, O., Budur, K., Vaughan, A. J., & Franco, K. (2006) · Psychosomatics · doi:10.1176/appi.psy.47.1.1 · Cited by 209 · see citing works
Organelle motility and metabolism in axons vs dendrites of cultured hippocampal neurons
Overly, C. C., Rieff, H. I., & Hollenbeck, P. J. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.5.971 · Cited by 200 · see citing works
Phosphorylation of Neurofilaments Is Altered in Amyotrophic Lateral Sclerosis
Manetto, V., Sternberger, N. H., Perry, G. L., Sternberger, L. A., & Gambetti, P. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198811000-00007 · Cited by 197 · see citing works
Cheung, E. C., Joza, N. A., Steenaart, N. A. E., McClellan, K. A., Neuspiel, M., McNamara, S., MacLaurin, J. G., Rippstein, P. U., Park, D. S., Shore, G. C., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601276 · Cited by 191 · see citing works
Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS
von Lewinski, F., & Keller, B. U. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.07.001 · Cited by 186 · see citing works
Fukui, H., Diaz, F., Garcia, S., & Moraes, C. T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705738104 · Cited by 185 · see citing works
Liu, D., Chan, S. L., de Souza-Pinto, N. C., Slevin, J. R., Wersto, R. P., Zhan, M., Mustafa, K., de Cabo, R., & Mattson, M. P. (2006) · NeuroMolecular Medicine · doi:10.1385/nmm:8:3:389 · Cited by 180 · see citing works
Self-citationMitochondrial Regulation of Synaptic Plasticity in the Hippocampus
Levy, M., Faas, G. C., Saggau, P., Craigen, W. J., & Sweatt, J. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212878200 · Cited by 179 · see citing works
Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage
Stichel, C. C., Zhu, X., Bader, V., Linnartz‐Gerlach, B., Schmidt, S., & Lübbert, H. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm083 · Cited by 179 · see citing works
Induction of neuronal death by α‐synuclein
Saha, R. A., Ninkina, N. N., Hanger, D. P., Anderton, B. H., Davies, A. M., & Buchman, V. L. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00210.x · Cited by 169 · see citing works
Poon, H. F., Frasier, M. A., Shreve, N., Calabrese, V., Wolozin, B. L., & Butterfield, D. A. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.12.009 · Cited by 165 · see citing works
Apoptosis in amyotrophic lateral sclerosis: a review of the evidence
Sathasivam, S., Ince, P. G., & Shaw, P. J. (2001) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2001.00332.x · Cited by 164 · see citing works
Endo, H., Kamada, H., Nito, C., Nishi, T., & Chan, P. H. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0897-06.2006 · Cited by 163 · see citing works
Stoica, B. A., Movsesyan, V. A., Lea, P. M., & Faden, A. I. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(02)00028-3 · Cited by 160 · see citing works
Son, M., Puttaparthi, K., Kawamata, H., Rajendran, B., Boyer, P. J., Manfredi, G., & Elliott, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610923104 · Cited by 160 · see citing works
Excitotoxicity and neurodegeneration in amyotrophic lateral sclerosis.
Rothstein, J. D. (1997) · PubMed · Cited by 157 · see citing works
Moustafa, R., & Baron, J.-C. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707530 · Cited by 156 · see citing works
Response of Mitochondrial Traffic to Axon Determination and Differential Branch Growth
Ruthel, G. T., & Hollenbeck, P. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08618.2003 · Cited by 155 · see citing works
NAD(P)H fluorescence imaging of postsynaptic neuronal activation in murine hippocampal slices
Shuttleworth, C. W., Brennan, A. M., & Connor, J. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03196.2003 · Cited by 151 · see citing works
Increased Autophagic Degradation of Mitochondria in Alzheimer Disease
Moreira, P. I., Siedlak, S. L., Wang, X., Santos, M. S., Oliveira, C. R., Tabaton, M., Nunomura, A., Szweda, L. I., Aliev, G. M., Smith, M. A., et al. (2007) · Autophagy · doi:10.4161/auto.4872 · Cited by 150 · see citing works
Mitochondrial fission and fusion dynamics: the long and short of it
Berman, S. B., Pineda, F. J., & Hardwick, J. M. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.57 · Cited by 146 · see citing works
Apoptosis and necrosis in health and disease: Role of mitochondria
Nieminen, A. (2003) · International review of cytology · doi:10.1016/s0074-7696(05)24002-0 · Cited by 145 · see citing works
The Chemistry of Peroxynitrite: Implications for Biological Activity
Goldstein, S., & Merényi, G. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)36004-2 · Cited by 145 · see citing works
Mutant Huntingtin Expression Induces Mitochondrial Calcium Handling Defects in Clonal Striatal Cells
Milakovic, T., Quintanilla, R. A., & Johnson, G. V. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603845200 · Cited by 142 · see citing works
Zhang, Y., & Lipton, P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-09-03307.1999 · Cited by 142 · see citing works
Caspase-Dependent and -Independent Neuronal Death: Two Distinct Pathways to Neuronal Injury
Stefanis, L. (2005) · The Neuroscientist · doi:10.1177/1073858404271087 · Cited by 142 · see citing works
BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II
Markham, A., Cameron, I., Franklin, P., & Spedding, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03578.x · Cited by 140 · see citing works
Amyotrophic lateral sclerosis models and human neuropathology: similarities and differences
Kato, S. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0308-4 · Cited by 139 · see citing works
Chang, D. T. W., & Reynolds, I. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.034 · Cited by 139 · see citing works
The Identity and Regulation of the Mitochondrial Permeability Transition Pore
Juhaszova, M., Wang, S., Zorov, D. B., Nuss, H. B., Gleichmann, M., Mattson, M. P., & Sollott, S. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1420.023 · Cited by 138 · see citing works
Self-citationStrain-Dependent Neurodevelopmental Abnormalities in Caspase-3-Deficient Mice
Leonard, J. R., Klocke, B. J., D’Sa-Eipper, C., Flavell, R. A., & Roth, K. A. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.8.673 · Cited by 135 · see citing works
Glazner, G. W., Chan, S. L., Lu, C., & Mattson, M. P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03641.2000 · Cited by 134 · see citing works
Self-citationBruce‐Keller, A. J., Li, Y., Lovell, M. A., Kraemer, P. J., Gary, D. S., Brown, R. R., Markesbery, W. R., & Mattson, M. P. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199803000-00007 · Cited by 133 · see citing works
Self-citationBrain-Derived Neurotrophic Factor Stimulates Energy Metabolism in Developing Cortical Neurons
Burkhalter, J., Fiumelli, H., Allaman, I., Chatton, J., & Martin, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-23-08212.2003 · Cited by 133 · see citing works
Hormesis/preconditioning mechanisms, the nervous system and aging
Arumugam, T. V., Gleichmann, M., Tang, S., & Mattson, M. P. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.03.003 · Cited by 131 · see citing works
Self-citationKorde, A. S., Pettigrew, L. C., Craddock, S. D., & Maragos, W. F. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03328.x · Cited by 126 · see citing works
Veereshwarayya, V., Kumar, P., Rosen, K. M., Mestril, R., & Querfurth, H. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602533200 · Cited by 125 · see citing works
Changes in Mitochondrial Function Resulting from Synaptic Activity in the Rat Hippocampal Slice
Bindokas, V. P., Lee, C. C., Colmers, W. F., & Miller, R. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04570.1998 · Cited by 125 · see citing works
Cai, H., Lin, X. Z., Xie, C., Laird, F. M., Lai, C., Wen, H., Chiang, H., Shim, H., Farah, M. H., Höke, A., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1645-05.2005 · Cited by 123 · see citing works
Dynamic Role of Postsynaptic Caspase-3 and BIRC4 in Zebra Finch Song-Response Habituation
Huesmann, G., & Clayton, D. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.033 · Cited by 118 · see citing works
Fernandes, H. B., Baimbridge, K. G., Church, J., Hayden, M. R., & Raymond, L. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3455-07.2007 · Cited by 117 · see citing works
Chan, S. L., Liu, D., Kyriazis, G. A., Bagsiyao, P., Ouyang, X., & Mattson, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605552200 · Cited by 116 · see citing works
Self-citationIntrathecal cyclosporin prolongs survival of late-stage ALS mice
Keep, M. F., Elmér, E., Fong, K. S. K., & Csiszár, K. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02012-1 · Cited by 114 · see citing works
Mitochondrial Dysfunction as the Molecular Basis of Bipolar Disorder
Kato, T. (2007) · CNS Drugs · doi:10.2165/00023210-200721010-00001 · Cited by 113 · see citing works
Nicholls, D. G., Vesce, S., Kirk, L., & Chalmers, S. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00144-1 · Cited by 108 · see citing works
Zhu, X., Yu, Q.-S., Cutler, R. G., Culmsee, C., Holloway, H. W., Lahiri, D. K., Mattson, M. P., & Greig, N. H. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm020044d · Cited by 105 · see citing works
Self-citationBax, Reactive Oxygen, and Cytochrome c Release in Neuronal Apoptosis
Kirkland, R. A., & Franklin, J. L. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603770310257 · Cited by 103 · see citing works
Participation of the mitochondrial genome in the differentiation of neuroblastoma cells
Vayssière, J., Cordeau‐Lossouarn, L., Larcher, J. C., Basseville, M., Gros, F., & Croizat, B. (1992) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/bf02631065 · Cited by 103 · see citing works
Duan, W., Rangnekar, V. M., & Mattson, M. P. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722312.x · Cited by 97 · see citing works
Self-citationβ-Amyloid Precursor Protein Is a Direct Cleavage Target of HtrA2 Serine Protease
Park, H., Kim, S. S., Seong, Y.-M., Kim, K., Goo, H. G., Yoon, E. J., Min, D. S., Kang, S., & Rhim, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603443200 · Cited by 95 · see citing works
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Zheng, Z., Lee, J. E., & Yenari, M. A. (2003) · Current Molecular Medicine · doi:10.2174/1566524033479717 · Cited by 93 · see citing works
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Atsumi, T. (1981) · Acta Neuropathologica · doi:10.1007/bf00691318 · Cited by 92 · see citing works
Transient Spine Expansion and Learning-Induced Plasticity in Layer 1 Primary Motor Cortex
Harms, K. J., Rioult-Pedotti, M. S., Carter, D. R., & Dunaevsky, A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0584-08.2008 · Cited by 92 · see citing works
Paroxetine retards disease onset and progression in Huntingtin mutant mice
Duan, W., Guo, Z., Jiang, H., Ladenheim, B., Xu, X. Z. S., Cadet, J. L., & Mattson, M. P. (2004) · Annals of Neurology · doi:10.1002/ana.20075 · Cited by 91 · see citing works
Self-citationMiyawaki, T., Mashiko, T., Ofengeim, D., Flannery, R. J., Noh, K.-M., Fujisawa, S., Bonanni, L., Bennett, M. V. L., Zukin, R. S., & Jonas, E. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800628105 · Cited by 89 · see citing works
Bogaerts, V., Theuns, J., & Broeckhoven, C. V. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00342.x · Cited by 86 · see citing works
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Mattson, M. P., Lu, C., Fu, W., et al. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:1:1:69 · Cited by 69 · see citing works
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Gulyaeva, N. V., Kudryashov, I. E., & Kudryashova, I. V. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10730 · Cited by 67 · see citing works
Liu, Q., & Shio, H. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000097 · Cited by 65 · see citing works
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Toresson, H., & Grant, S. G. N. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04342.x · Cited by 63 · see citing works
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Li, X., Chlan‐Fourney, J., Juorio, A. V., Bennett, V. L., Shrikhande, S., Keegan, D. L., Jin, Q., & Boulton, A. A. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990401)56:1 · Cited by 57 · see citing works
Cheng, A., Arumugam, T. V., Liu, D., Khatri, R. G., Mustafa, K., Kwak, S., Ling, H.-P., Gonzales, C., Xin, O., Jo, D.-G., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5154-06.2007 · Cited by 56 · see citing works
Self-citationPrince, J. A. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00111-6 · Cited by 55 · see citing works
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Wang, H., Guan, Y., Wang, X., Smith, K., Cormier, K., Zhu, S., Stavrovskaya, I. G., Huo, C., Ferrante, R. J., Kristal, B. S., et al. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05663.x · Cited by 53 · see citing works
Lu, C., Wang, Y., Furukawa, K., Fu, W., Ouyang, X., & Mattson, M. P. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03800.x · Cited by 51 · see citing works
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Masuda, N., Peng, Q., Li, Q., Jiang, M., Liang, Y., Wang, X., Zhao, M., Wang, W., Ross, C. A., & Duan, W. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.01.014 · Cited by 51 · see citing works
Organization of mitochondria in olfactory bulb granule cell dendritic spines
Cameron, H. A., Kaliszewski, C. K., & Greer, C. A. (1991) · Synapse · doi:10.1002/syn.890080205 · Cited by 49 · see citing works
Korde, A. S., Pettigrew, L. C., Craddock, S. D., Pocernich, C. B., Waldmeier, P. C., & Maragos, W. F. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0122 · Cited by 48 · see citing works
Darios, F. D., Muriel, M., Escobar-Khondiker, M., Brice, A., & Ruberg, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0060-05.2005 · Cited by 48 · see citing works
Depressive disorder due to mitochondrial transfer RNALeu(UUR) mutation
Onishi, H., Kawanishi, C., Iwasawa, T., Osaka, H., Hanihara, T., Inoue, K., Yamada, Y., & Kosaka, K. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00005-x · Cited by 42 · see citing works
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Green, D. R., Galluzzi, L., & Kroemer, G. (2011) · Science · doi:10.1126/science.1201940 · Cited by 1,245 · see citing works
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Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, V. A., & Fang, E. F. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.01.002 · Cited by 870 · see citing works
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Guo, X., Aviles, G., Liu, Y., Tian, R., Unger, B. A., Lin, Y.-H. T., Wiita, A. P., Xu, K., Correia, M. A., & Kampmann, M. (2020) · Nature · doi:10.1038/s41586-020-2078-2 · Cited by 674 · see citing works
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Wakabayashi, J., Zhang, Z., Wakabayashi, N., Tamura, Y., Fukaya, M., Kensler, T. W., Iijima, M., & Sesaki, H. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903065 · Cited by 667 · see citing works
Kapogiannis, D., & Mattson, M. P. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70277-5 · Cited by 594 · see citing works
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Gupte, R. P., Brooks, W. M., Vukas, R. R., Pierce, J. D., & Harris, J. L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6171 · Cited by 533 · see citing works
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Liu, Y., Cheng, A., Li, Y.-J., Yang, Y., Kishimoto, Y., Zhang, S., Wang, Y., Wan, R., Raefsky, S. M., Lu, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09897-1 · Cited by 176 · see citing works
Self-citationEckert, A., Schmitt, K., & Götz, J. (2011) · Alzheimer's Research & Therapy · doi:10.1186/alzrt74 · Cited by 177 · see citing works
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Self-citationChang, K. T., Niescier, R. F., & Min, K.-T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106862108 · Cited by 153 · see citing works
Silaidos, C., Pilatus, U., Grewal, R., Matura, S., Lienerth, B., Pantel, J., & Eckert, G. P. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0193-7 · Cited by 137 · see citing works
Berchtold, N. C., Sabbagh, M. N., Beach, T. G., Kim, R. C., Cribbs, D. H., & Cotman, C. W. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.031 · Cited by 124 · see citing works
Real, C. C., Ferreira, A. F. B., Chaves-Kirsten, G. P., Torrão, A. S., Pires, R. S., & Britto, L. R. G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.060 · Cited by 109 · see citing works
Bernardo, T. C., Marques‐Aleixo, I., Beleza, J., Oliveira, P. J., Ascensão, A., & Magalhães, J. (2016) · Brain Pathology · doi:10.1111/bpa.12403 · Cited by 108 · see citing works
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Yoon, S., Kim, J. E., Hwang, J., Kim, T.-S., Kang, H. J., Namgung, E., Ban, S., Oh, S., Yang, J., Renshaw, P. F., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.027 · Cited by 71 · see citing works
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Horváth, S., Janka, Z., & Mirnics, K. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.017 · Cited by 64 · see citing works
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Pei, L., Mu, Y., Leblanc, M., Alaynick, W., Barish, G. D., Pankratz, M., Tseng, T. W., Kaufman, S., Liddle, C., Yu, R. T., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.03.004 · Cited by 65 · see citing works
Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders
Adzic, M., Brkic, Z., Bulajic, S., Mitic, M., & Radojcic, M. B. (2016) · Drug Development Research · doi:10.1002/ddr.21332 · Cited by 60 · see citing works
Risks of cognitive detriments after low dose heavy ion and proton exposures
Cucinotta, F. A., & Cacao, E. (2019) · International Journal of Radiation Biology · doi:10.1080/09553002.2019.1623427 · Cited by 58 · see citing works
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Chen, J., & Vitetta, L. (2020) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29311 · Cited by 36 · see citing works
Hou, Y., Mattson, M. P., & Cheng, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076721 · Cited by 39 · see citing works
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Newton, D. F., Oh, H., Shukla, R., Misquitta, K., Fee, C., Banasr, M., & Sibille, E. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.10.015 · Cited by 19 · see citing works
Falkovich, R., Aryal, S., Sheng, M., & Bathe, M. (2024) · doi:10.1101/2024.10.28.620504 · Cited by 2 · see citing works
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“73,75 Experiments isolating mitochondria from brain tissue of animal models of aging and disease revealed deficits in ETC function when compared to young healthy animals.”
- Authors
- Mattson, M. P., Gleichmann, M., & Cheng, A.
- Affiliations
- National Institute on Aging (US)
- Corresponding author
- Mattson, Mark P.
- ORCID
- Mattson, Mark P.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 60
- Issue
- 5
- Pages
- 748-766
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2692277
- OpenAlex
- W2010179451
- Cited by
- 1,081
- References
- 210
- Citations by year
- 2026: 57 · 2025: 59 · 2024: 58 · 2023: 67 · 2022: 74 · 2021: 89 · 2020: 83 · 2019: 62 · 2018: 61 · 2017: 69 · 2016: 65 · 2015: 50 · 2014: 44 · 2013: 47 · 2012: 65
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
- Keywords
- mitochondria, neuroplasticity, neurological disorders, mitochondrial dynamics, mitochondrial fission and fusion, calcium homeostasis, redox signaling, synaptic plasticity, neuronal excitability, mitochondrial DNA mutations, oxidative stress, apoptosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, amyotrophic lateral sclerosis, mental illness
- MeSH terms
- Animals, Humans, Mitochondria, Models, Biological, Nervous System Diseases, Neuronal Plasticity, Mitochondrial Proteins, Electron Transport Complex I
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