The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion
Open accessAbstract
Postprandial insulin release is regulated by glucose, but other circulating nutrients may target beta cells and potentiate glucose-stimulated insulin secretion via distinct signaling pathways. We demonstrate that fructose activates sweet taste receptors (TRs) on beta cells and synergizes with glucose to amplify insulin release in human and mouse islets. Genetic ablation of the sweet TR protein T1R2 obliterates fructose-induced insulin release and its potentiating effects on glucose-stimulated insulin secretion in vitro and in vivo. TR signaling in beta cells is triggered, at least in part, in parallel with the glucose metabolic pathway and leads to increases in intracellular calcium that are dependent on the activation of phospholipase C (PLC) and transient receptor potential cation channel, subfamily M, member 5 (TRPM5). Our results unveil a pathway for the regulation of insulin release by postprandial nutrients that involves beta cell sweet TR signaling.
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Cites
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 3×
“Our data, together with previous reports showing that sweet TRs in the intestinal epithelium stimulate dietary glucose absorption and regulate GLP-1 secretion (16, 50, 51), suggest a TR-dependent intestinopancreatic axis that participates in the regulation of postprandial insulin release by absorbed sugars.”
BackgroundResultT1R3 and gustducin in gut sense sugars to regulate expression of Na + -glucose cotransporter 1
Margolskee, R. F., Dyer, J., Kokrashvili, Z., Salmon, K. S. H., Ilegems, E., Daly, K., Maillet, E. L., Ninomiya, Y., Mosinger, B., & Shirazi-Beechey, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706678104 · Cited by 882
Intense sweeteners, energy intake and the control of body weight.
Bellisle, F., & Drewnowski, A. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602649 · Cited by 200
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Vanadium compounds in medicine
Pessoa, J. C., Etcheverry, S., & Gambino, D. (2015) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2014.12.002 · Cited by 561
Metabolic Signaling in Fuel-Induced Insulin Secretion
Prentki, M., Matschinsky, F. M., & Madiraju, S. R. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.018 · Cited by 548
Transient receptor potential (TRP) channels: a clinical perspective
Kaneko, Y., & Szallasi, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 370
Pancreatic β-cell identity, glucose sensing and the control of insulin secretion
Rutter, G. A., Pullen, T. J., Hodson, D. J., & Martinez-Sanchez, A. (2015) · Biochemical Journal · doi:10.1042/bj20141384 · Cited by 339
Metabolic effects of non-nutritive sweeteners
Pepino, M. Y. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.06.024 · Cited by 285
Metadata
- Authors
- Kyriazis, G. A., Soundarapandian, M. M., & Tyrberg, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-02-06
- Volume
- 109
- Issue
- 8
- Pages
- E524-32
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2163903769
- Cited by
- 232
- References
- 3
- FWCI
- 22.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Kyriazis, G. A., Soundarapandian, M. M., & Tyrberg, B. (2012). Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1115183109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
