The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A
Open accessAbstract
Cyclophilin A (CyPA) is specifically incorporated into the virions of HIV-1 and has been shown to enhance significantly an early step of cellular HIV-1 infection. Our preliminary studies implicated CD147 as a receptor for extracellular CyPA. Here, we demonstrate a role for CyPA–CD147 interaction during the early steps of HIV-1 infection. Expression of human CD147 increased infection by HIV-1 under one-cycle conditions. However, susceptibility to infection by viruses lacking CyPA (simian immunodeficiency virus or HIV-1 produced in the presence of cyclosporin A) was unaffected by CD147. Virus-associated CyPA coimmunoprecipitated with CD147 from infected cells. Antibody to CD147 inhibited HIV-1 entry as evidenced by the delay in translocation of the HIV-1 core proteins from the membrane and inhibition of viral reverse transcription. Viruses whose replication did not require CyPA (SIV or mutant HIV-1) were resistant to the inhibitory effect of anti-CD147 antibody. These results suggest that HIV-1 entry depends on an interaction between virus-associated CyPA and CD147 on a target cell.
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Cites
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116
Specific incorporation of cyclophilin A into HIV-1 virions
Franke, E. K., Yuan, H. E. H., & Luban, J. (1994) · Nature · doi:10.1038/372359a0 · Cited by 745
Bukrinsky, M. I., Sharova, N., McDonald, T. L., Pushkarskaya, T., Tarpley, W. G., & Stevenson, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6125 · Cited by 451
Self-citation
Cited by
Halestrap, A. P. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c130008 · Cited by 339
Muramatsu, T., & Miyauchi, T. (2003) · PubMed · doi:10.14670/hh-18.981 · Cited by 277
Ashary, N., Bhide, A., Chakraborty, P., Colaco, S., Mishra, A., Chhabria, K., Jolly, M. K., & Modi, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00783 · Cited by 121
Clathrin-independent endocytosis: A cargo-centric view
Maldonado-Báez, L., Williamson, C., & Donaldson, J. G. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.08.008 · Cited by 97
Cyclophilin A/CD147 Interaction: A Promising Target for Anticancer Therapy
Han, J. M., & Jung, H. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169341 · Cited by 75
Metadata
- Authors
- Pushkarsky, T., Zybarth, G., Dubrovsky, L., Yurchenko, V., Tang, H., Guo, H., Toole, B., Sherry, B., & Bukrinsky, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-05-15
- Volume
- 98
- Issue
- 11
- Pages
- 6360-6365
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977513191
- Cited by
- 270
- References
- 3
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Pushkarsky, T., Zybarth, G., Dubrovsky, L., Yurchenko, V., Tang, H., Guo, H., Toole, B., Sherry, B., & Bukrinsky, M. (2001). CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.111583198
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