Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750 · see citing works

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

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SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

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Transcriptional Mechanisms Underlying Lymphocyte Tolerance

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Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway

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The Forkhead Transcription Factor FoxO Regulates Transcription of p27 Kip1 and Bim in Response to IL-2

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Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

Heissmeyer, V., Macián, F., Im, S., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y., Dustin, M. L., & Rao, A. (2004) · Nature Immunology · doi:10.1038/ni1047 · Cited by 515 · see citing works

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

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Egr-2 and Egr-3 are negative regulators of T cell activation

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Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 + T Cells

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Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

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The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

Zhang, J., Lee, S., Shannon, S., Gao, B., Chen, W., Chen, A., Divekar, R. D., McBurney, M. W., Braley‐Mullen, H., Zaghouani, H., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38902 · Cited by 289 · see citing works

Untitled work

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The Akt-regulated Forkhead Transcription Factor FOXO3a Controls Endothelial Cell Viability through Modulation of the Caspase-8 Inhibitor FLIP

Skurk, C., Maatz, H., Kim, H.-S., Jiang, Y., Abid, M. R., Aird, W. C., & Walsh, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m304736200 · Cited by 271 · see citing works

Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells

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Molecular mechanisms of CD4+ T-cell anergy

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Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

Waldner, H., Collins, M. A., & Kuchroo, V. K. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19388 · Cited by 198 · see citing works

Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T Cell Hyperactivation

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Sequential Involvement of NFAT and Egr Transcription Factors in FasL Regulation

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Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes

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sirt1-null mice develop an autoimmune-like condition

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Phospholipase Cγ1 is essential for T cell development, activation, and tolerance

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Dendritic cells as targets for therapy in rheumatoid arthritis

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NF-κB Signaling in the Aging Process

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Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells

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In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.

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FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1

Lee, S., Gao, B., & Fang, D. (2008) · Blood · doi:10.1182/blood-2007-09-115014 · Cited by 103 · see citing works

The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation

Kong, S., Kim, S.-J., Sandal, B., Lee, S., Gao, B., Zhang, D. D., & Fang, D. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.218206 · Cited by 98 · see citing works

Distinct migration patterns of naive and effector CD8 T cells in the spleen: correlation with CCR7 receptor expression and chemokine reactivity

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Regulation of T‐cell tolerance by calcium/NFAT signaling

Baine, I. L., Abe, B. T., & Macián, F. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00817.x · Cited by 92 · see citing works

Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance

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The HECT-Type E3 Ubiquitin Ligase AIP2 Inhibits Activation-Induced T-Cell Death by Catalyzing EGR2 Ubiquitination

Chen, A., Gao, B., Zhang, J., McEwen, T. J., Ye, S. Q., Zhang, D. D., & Fang, D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00407-09 · Cited by 51 · see citing works

Tolerance and Ways to Break Ita

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The sound of silence: modulating anergy in T lymphocytes

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Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

Waldner, H., Collins, M. K., & Kuchroo, V. K. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419388 · Cited by 30 · see citing works

T-cell Tolerance and Autoimmune Diabetes

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T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

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Redox regulation of SIRT1 in inflammation and cellular senescence

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USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development

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P6-003 Sirtuin-1はヒト単球のinterleukin-10制御に関与する

雄生, 宮., 正明, 新., 俊行, 深., et al. (2014) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.37.357a

Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors

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Sirtuin‐1 deacetylation of p53 plays a role in shear stress‐induced autophagy in endothelial cells

Ting, P., Wu, L., & Wang, D. L. (2017) · The FASEB Journal · doi:10.1096/fasebj.31.1_supplement.lb662

Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors

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Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors

Angibaud, P. R., Emelen, K. V., Decrane, L., Brandt, S. V., ten Holte, P., Pilatte, I., Roux, B., Poncelet, V., Speybrouck, D., Quéguiner, L., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.10.118 · Cited by 18 · see citing works