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Cited by 272

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model

Open access
Jin, Cong, Liang, Mifang, Ning, Junyu, Gu, Wen, Jiang, Hong, Wu, Wei, Zhang, Fushun, Li, Chuan, Zhang, Quanfu, Zhu, Hua, Chen, Ting, Han, Ying, Zhang, Weilun, Zhang, Shuo, Wang, Qin, Sun, Lina, Liu, Qinzhi, Li, Jiandong, Wang, Tao, Wei, Qiang, Wang, Shiwen, Deng, Ying, Qin, Chuan, Li, Dexin·2012·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1120246109
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Abstract

The discovery of an emerging viral disease, severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV), has prompted the need to understand pathogenesis of SFTSV. We are unique in establishing an infectious model of SFTS in C57/BL6 mice, resulting in hallmark symptoms of thrombocytopenia and leukocytopenia. Viral RNA and histopathological changes were identified in the spleen, liver, and kidney. However, viral replication was only found in the spleen, which suggested the spleen to be the principle target organ of SFTSV. Moreover, the number of macrophages and platelets were largely increased in the spleen, and SFTSV colocalized with platelets in cytoplasm of macrophages in the red pulp of the spleen. In vitro cellular assays further revealed that SFTSV adhered to mouse platelets and facilitated the phagocytosis of platelets by mouse primary macrophages, which in combination with in vivo findings, suggests that SFTSV-induced thrombocytopenia is caused by clearance of circulating virus-bound platelets by splenic macrophages. Thus, this study has elucidated the pathogenic mechanisms of thrombocytopenia in a mouse model resembling human SFTS disease.

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Metadata

Authors
Jin, C., Liang, M., Ning, J., Gu, W., Jiang, H., Wu, W., Zhang, F., Li, C., Zhang, Q., Zhu, H., Chen, T., Han, Y., Zhang, W., Zhang, S., Wang, Q., Sun, L., Liu, Q., Li, J., Wang, T., Wei, Q., Wang, S., Deng, Y., Qin, C., & Li, D.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2012-06-04
Volume
109
Issue
25
Pages
10053-10058
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1120246109
OpenAlex
W1987995337
Cited by
272
References
16
FWCI
9.31
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model. https://app.cochat.ai/papers/10.1073/pnas.1120246109
The paper
Jin, C., Liang, M., Ning, J., Gu, W., Jiang, H., Wu, W., Zhang, F., Li, C., Zhang, Q., Zhu, H., Chen, T., Han, Y., Zhang, W., Zhang, S., Wang, Q., Sun, L., Liu, Q., Li, J., Wang, T., . . . Li, D. (2012). Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1120246109

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.