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The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan
Open accessAbstract
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV), a novel bunyavirus reported to be endemic in central and northeastern China. This article describes the first identified patient with SFTS and a retrospective study on SFTS in Japan. METHODS: Virologic and pathologic examinations were performed on the patient's samples. Laboratory diagnosis of SFTS was made by isolation/genome amplification and/or the detection of anti-SFTSV immunoglobulin G antibody in sera. Physicians were alerted to the initial diagnosis and asked whether they had previously treated patients with symptoms similar to those of SFTS. RESULTS: A female patient who died in 2012 received a diagnosis of SFTS. Ten additional patients with SFTS were then retrospectively identified. All patients were aged ≥50 years and lived in western Japan. Six cases were fatal. The ratio of males to females was 8:3. SFTSV was isolated from 8 patients. Phylogenetic analyses indicated that all of the Japanese SFTSV isolates formed a genotype independent to those from China. Most patients showed symptoms due to hemorrhage, possibly because of disseminated intravascular coagulation and/or hemophagocytosis. CONCLUSIONS: SFTS has been endemic to Japan, and SFTSV has been circulating naturally within the country.
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Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China
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A New Phlebovirus Associated with Severe Febrile Illness in Missouri
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Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model
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Bao, C.-J., Guo, X.-L., Qi, X., Hu, J.-L., Zhou, M.-H., Varma, J. K., Cui, L.-B., Yang, H.-T., Jiao, Y.-J., Klena, J. D., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir732 · Cited by 269
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Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase
FURUTA, Y., KOMENO, T., & NAKAMURA, T. (2017) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.93.027 · Cited by 1,070
Zoonotic diseases: etiology, impact, and control
Rahman, M. T., Sobur, M. A., Islam, M. S., Ievy, S., Hossain, M. J., El Zowalaty, M. E., Rahman, A. T., & Ashour, H. M. (2020) · Microorganisms · doi:10.3390/microorganisms8091405 · Cited by 853
Mayer, S. V., Tesh, R. B., & Vasilakis, N. (2017) · Acta Tropica · doi:10.1016/j.actatropica.2016.11.020 · Cited by 470
Metadata
- Authors
- Takahashi, T., Maeda, K., Suzuki, T., Ishido, A., Shigeoka, T., Tominaga, T., Kamei, T., Honda, M., Ninomiya, D., Sakai, T., Senba, T., Kaneyuki, S., Sakaguchi, S., Satoh, A., Hosokawa, T., Kawabe, Y., Kurihara, S., Izumikawa, K., Kohno, S., Azuma, T., Suemori, K., Yasukawa, M., Mizutani, T., Omatsu, T., Katayama, Y., Miyahara, M., Ijuin, M., Doi, K., Okuda, M., Umeki, K., Saito, T., Fukushima, K., Nakajima, K., Yoshikawa, T., Tani, H., Fukushi, S., Fukuma, A., Ogata, M., Shimojima, M., Nakajima, N., Nagata, N., Katano, H., Fukumoto, H., Sato, Y., Hasegawa, H., Yamagishi, T., Oishi, K., Kurane, I., Morikawa, S., & Saijo, M.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-11-14
- Volume
- 209
- Issue
- 6
- Pages
- 816-827
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2103612325
- Cited by
- 958
- References
- 14
- FWCI
- 31.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Takahashi, T., Maeda, K., Suzuki, T., Ishido, A., Shigeoka, T., Tominaga, T., Kamei, T., Honda, M., Ninomiya, D., Sakai, T., Senba, T., Kaneyuki, S., Sakaguchi, S., Satoh, A., Hosokawa, T., Kawabe, Y., Kurihara, S., Izumikawa, K., Kohno, S., . . . Saijo, M. (2014). The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jit603
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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