The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation
Open accessAbstract
Cofactors for estrogen receptor α (ERα) can modulate gene activity by posttranslationally modifying histone tails at target promoters. Here, we found that stimulation of ERα-positive cells with 17β-estradiol (E2) promotes global citrullination of histone H3 arginine 26 (H3R26) on chromatin. Additionally, we found that the H3 citrulline 26 (H3Cit26) modification colocalizes with ERα at decondensed chromatin loci surrounding the estrogen-response elements of target promoters. Surprisingly, we also found that citrullination of H3R26 is catalyzed by peptidylarginine deiminase (PAD) 2 and not by PAD4 (which citrullinates H4R3). Further, we showed that PAD2 interacts with ERα after E2 stimulation and that inhibition of either PAD2 or ERα strongly suppresses E2-induced H3R26 citrullination and ERα recruitment at target gene promoters. Collectively, our data suggest that E2 stimulation induces the recruitment of PAD2 to target promoters by ERα, whereby PAD2 then citrullinates H3R26, which leads to local chromatin decondensation and transcriptional activation.
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Cites
Voss, T. C., Schiltz, R. L., Sung, M.-H., Yen, P. M., Stamatoyannopoulos, J. A., Biddie, S. C., Johnson, T. A., Miranda, T. B., John, S., & Hager, G. L. (2011) · Cell · doi:10.1016/j.cell.2011.07.006 · Cited by 307
Sun, J., Nawaz, Z., & Slingerland, J. M. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0082 · Cited by 83
Cited by
Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442
Quantitative Proteomic Analysis of Histone Modifications
Huang, H., Lin, S., Garcia, B. A., & Zhao, Y. (2015) · Chemical Reviews · doi:10.1021/cr500491u · Cited by 370
Witalison, E., Thompson, P., & Hofseth, L. (2015) · Current Drug Targets · doi:10.2174/1389450116666150202160954 · Cited by 310
Self-citationGnRH Stimulates Peptidylarginine Deiminase Catalyzed Histone Citrullination in Gonadotrope Cells
Khan, S. A., Edwards, B. S., Muth, A., Thompson, P. R., Cherrington, B. D., & Navratil, A. M. (2016) · Molecular Endocrinology · doi:10.1210/me.2016-1085 · Cited by 21
Self-citation(2024) · doi:10.1016/j.isci.2024.109584 · Cited by 6
Metadata
- Authors
- Zhang, X., Bolt, M., Guertin, M. J., Chen, W., Zhang, S., Cherrington, B. D., Slade, D. J., Dreyton, C. J., Subramanian, V., Bicker, K. L., Thompson, P. R., Mancini, M. A., Lis, J. T., & Coonrod, S. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-08
- Volume
- 109
- Issue
- 33
- Pages
- 13331-13336
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2081340836
- Cited by
- 211
- References
- 2
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, X., Bolt, M., Guertin, M. J., Chen, W., Zhang, S., Cherrington, B. D., Slade, D. J., Dreyton, C. J., Subramanian, V., Bicker, K. L., Thompson, P. R., Mancini, M. A., Lis, J. T., & Coonrod, S. A. (2012). Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1203280109
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