The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
RETRACTED: Stabilization of vaccines and antibiotics in silk and eliminating the cold chain
Open accessAbstract
Sensitive biological compounds, such as vaccines and antibiotics, traditionally require a time-dependent “cold chain” to maximize therapeutic activity. This flawed process results in billions of dollars worth of viable drug loss during shipping and storage, and severely limits distribution to developing nations with limited infrastructure. To address these major limitations, we demonstrate self-standing silk protein biomaterial matrices capable of stabilizing labile vaccines and antibiotics, even at temperatures up to 60 °C over more than 6 months. Initial insight into the mechanistic basis for these findings is provided. Importantly, these findings suggest a transformative approach to the cold chain to revolutionize the way many labile therapeutic drugs are stored and utilized throughout the world.
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Citations
Cites
Altman, G. H., Diaz, F., Jakuba, C., Calabro, T., Horan, R. L., Chen, J., Lu, H., Richmond, J., & Kaplan, D. L. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00353-8 · Cited by 3,458
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Cited by
Silk biomaterials in wound healing and skin regeneration therapeutics: From bench to bedside
Chouhan, D., & Mandal, B. B. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.11.050 · Cited by 348
Controlled release of cytokines using silk-biomaterials for macrophage polarization
Reeves, A. R. D., Spiller, K. L., Freytes, D. O., Vunjak-Novakovic, G., & Kaplan, D. L. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.09.027 · Cited by 131
Self-citationThermal stability of self-assembled peptide vaccine materials
Sun, T., Han, H., Hudalla, G. A., Wen, Y., Pompano, R. R., & Collier, J. H. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.11.019 · Cited by 76
Metadata
- Authors
- Zhang, J., Pritchard, E., Hu, X., Valentin, T., Panilaitis, B., Omenetto, F. G., & Kaplan, D. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2012-07-09
- Volume
- 109
- Issue
- 30
- Pages
- 11981-11986
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079477627
- Cited by
- 168
- References
- 1
- FWCI
- 7.94
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- green
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- Zhang, J., Pritchard, E., Hu, X., Valentin, T., Panilaitis, B., Omenetto, F. G., & Kaplan, D. L. (2012). RETRACTED: Stabilization of vaccines and antibiotics in silk and eliminating the cold chain. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1206210109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
