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Cited by 548

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Exaggerated phase–amplitude coupling in the primary motor cortex in Parkinson disease

Open access
de Hemptinne, Coralie, Ryapolova-Webb, Elena S., Air, Ellen L., Garcia, Paul A., Miller, Kai J., Ojemann, Jeffrey G., Ostrem, Jill L., Galifianakis, Nicholas B., Starr, Philip A.·2013·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1214546110
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Abstract

An important mechanism for large-scale interactions between cortical areas involves coupling between the phase and the amplitude of different brain rhythms. Could basal ganglia disease disrupt this mechanism? We answered this question by analysis of local field potentials recorded from the primary motor cortex (M1) arm area in patients undergoing neurosurgery. In Parkinson disease, coupling between β-phase (13–30 Hz) and γ-amplitude (50–200 Hz) in M1 is exaggerated compared with patients with craniocervical dystonia and humans without a movement disorder. Excessive coupling may be reduced by therapeutic subthalamic nucleus stimulation. Peaks in M1 γ-amplitude are coupled to, and precede, the subthalamic nucleus β-trough. The results prompt a model of the basal ganglia–cortical circuit in Parkinson disease incorporating phase–amplitude interactions and abnormal corticosubthalamic feedback and suggest that M1 local field potentials could be used as a control signal for automated programming of basal ganglia stimulators.

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Metadata

Authors
de Hemptinne, C., Ryapolova-Webb, E. S., Air, E. L., Garcia, P. A., Miller, K. J., Ojemann, J. G., Ostrem, J. L., Galifianakis, N. B., & Starr, P. A.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2013-03-07
Volume
110
Issue
12
Pages
4780-4785
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1214546110
OpenAlex
W1987095365
Cited by
548
References
45
FWCI
24.51
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Exaggerated phase–amplitude coupling in the primary motor cortex in Parkinson disease. https://app.cochat.ai/papers/10.1073/pnas.1214546110
The paper
de Hemptinne, C., Ryapolova-Webb, E. S., Air, E. L., Garcia, P. A., Miller, K. J., Ojemann, J. G., Ostrem, J. L., Galifianakis, N. B., & Starr, P. A. (2013). Exaggerated phase–amplitude coupling in the primary motor cortex in Parkinson disease. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1214546110

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.