Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease
Open accessAbstract
Deep brain stimulation (DBS) is increasingly applied for the treatment of brain disorders, but its mechanism of action remains unknown. Here we evaluate the effect of basal ganglia DBS on cortical function using invasive cortical recordings in Parkinson's disease (PD) patients undergoing DBS implantation surgery. In the primary motor cortex of PD patients, neuronal population spiking is excessively synchronized to the phase of network oscillations. This manifests in brain surface recordings as exaggerated coupling between the phase of the beta rhythm and the amplitude of broadband activity. We show that acute therapeutic DBS reversibly reduces phase-amplitude interactions over a similar time course as that of the reduction in parkinsonian motor signs. We propose that DBS of the basal ganglia improves cortical function by alleviating excessive beta phase locking of motor cortex neurons.
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DBS for movement disorders is commonly believed to disrupt the function of pathologically hyper-connected motor circuitry.
“DBS for movement disorders is commonly believed to disrupt the function of pathologically hyper-connected motor circuitry (de Hemptinne et al. 2015, Herrington et al. 2015).”
From Deep brain stimulation for psychiatric disorders: From focal brain targets to cognitive networks (2021) · cites this paper as de Hemptinne et al. 2015
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BackgroundRamirez-Zamora, A., Giordano, J., Boyden, E. S., Gradinaru, V., Gunduz, A., Starr, P. A., Sheth, S. A., McIntyre, C. C., Fox, M. D., Vitek, J., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00936 · Cited by 37 · see citing works
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- Authors
- de Hemptinne, C., Swann, N. C., Ostrem, J. L., Ryapolova-Webb, E. S., San Luciano, M., Galifianakis, N. B., & Starr, P. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Nature Neuroscience
- Published
- 2015-04-13
- Volume
- 18
- Issue
- 5
- Pages
- 779-786
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4414895
- OpenAlex
- W1967428268
- Cited by
- 623
- References
- 61
- Citations by year
- 2026: 40 · 2025: 41 · 2024: 48 · 2023: 40 · 2022: 65 · 2021: 55 · 2020: 75 · 2019: 58 · 2018: 74 · 2017: 40 · 2016: 52 · 2015: 34
- FWCI
- 47.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Michael J. Fox Foundation for Parkinson's Research
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS069779)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, Parkinson's disease, phase-amplitude coupling, beta oscillations, primary motor cortex, basal ganglia, neuronal synchronization, cortical oscillations
- MeSH terms
- Aged, Arm, Basal Ganglia, Beta Rhythm, Electromyography, Female, Humans, Male, Middle Aged, Motor Cortex, Movement, Muscle Rigidity, Parkinson Disease, Tremor, Deep Brain Stimulation, Accelerometry
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