Cited by 317Bacterial biofilms and quorum sensingBacterial Genetics and BiotechnologyAntibiotic Resistance in Bacteria

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Community surveillance enhances Pseudomonas aeruginosa virulence during polymicrobial infection

Open access

Korgaonkar, Aishwarya, Trivedi, Urvish, Rumbaugh, Kendra P., Whiteley, Marvin·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1214550110PMC PMC3549110

Open this paper in CoChat — free account

Abstract

Most infections result from colonization by more than one microbe. Within such polymicrobial infections, microbes often display synergistic interactions that result in increased disease severity. Although many clinical studies have documented the occurrence of synergy in polymicrobial infections, little is known about the underlying molecular mechanisms. A prominent pathogen in many polymicrobial infections is Pseudomonas aeruginosa, a Gram-negative bacterium that displays enhanced virulence during coculture with Gram-positive bacteria. In this study we discovered that during coinfection, P. aeruginosa uses peptidoglycan shed by Gram-positive bacteria as a cue to stimulate production of multiple extracellular factors that possess lytic activity against prokaryotic and eukaryotic cells. Consequently, P. aeruginosa displays enhanced virulence in a Drosophila model of infection when cocultured with Gram-positive bacteria. Inactivation of a gene (PA0601) required for peptidoglycan sensing mitigated this phenotype. Using Drosophila and murine models of infection, we also show that peptidoglycan sensing results in P. aeruginosa-mediated reduction in the Gram-positive flora in the infection site. Our data suggest that P. aeruginosa has evolved a mechanism to survey the microbial community and respond to Gram-positive produced peptidoglycan through production of antimicrobials and toxins that not only modify the composition of the community but also enhance host killing. Additionally, our results suggest that therapeutic strategies targeting Gram-positive bacteria might be a viable approach for reducing the severity of P. aeruginosa polymicrobial infections.

Integrity signals

Registry

Crossref · 10.1073/pnas.1214550110

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection
Girardin, S. E., Boneca, I. G., Viala, J., Chamaillard, M., Labigne-Roussel, A., Thomas, G. D., Philpott, D. J., & Sansonetti, P. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200651200 · Cited by 2,397
Chitin metabolism in insects: structure, function and regulation of chitin synthases and chitinases
Merzendorfer, H., & Zimoch, L. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00709 · Cited by 1,270
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
Pesci, E. C., Milbank, J. B. J., Pearson, J. P., McKnight, S. L., Kende, A. S., Greenberg, E. P., & Iglewski, B. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11229 · Cited by 1,115
An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants
Liberati, N. T., Urbach, J. M., Miyata, S., Lee, D. G., Drenkard, E., Wu, G., Villanueva, J. M., Wei, T., & Ausubel, F. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511100103 · Cited by 943
Identification and characterization of genes for a second anthranilate synthase in Pseudomonas aeruginosa: interchangeability of the two anthranilate synthases and evolutionary implications
Essar, D. W., Eberly, L., Hadero, A., & Crawford, I. P. (1990) · Journal of Bacteriology · doi:10.1128/jb.172.2.884-900.1990 · Cited by 929
Molecular basis of intercellular adhesion in the biofilm‐forming Staphylococcus epidermidis
Heilmann, C., Schweitzer, O., Gerke, C., Vanittanakom, N., Mack, D., & Götz, F. (1996) · Molecular Microbiology · doi:10.1111/j.1365-2958.1996.tb02548.x · Cited by 912
Molecular Mechanisms of Bacterial Virulence Elucidated Using a Pseudomonas aeruginosa– Caenorhabditis elegans Pathogenesis Model
Mahajan‐Miklos, S., Tan, M., Rahme, L. G., & Ausubel, F. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80958-7 · Cited by 821
Short protocols in molecular biology. A compendium of methods from current protocols in molecular biology
(1990) · Gene · doi:10.1016/0378-1119(90)90070-8 · Cited by 741
Polymicrobial Interactions: Impact on Pathogenesis and Human Disease
Peters, B. M., Jabra‐Rizk, M. A., O’May, G. A., Costerton, J. W., & Shirtliff, M. E. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00013-11 · Cited by 733
The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density‐dependency of the quorum sensing hierarchy, regulates rhl‐dependent genes at the onset of stationary phase and can be produced in the absence of LasR
Diggle, S. P., Winzer, K., Chhabra, S. R., Worrall, K. E., Cámara, M., & Williams, P. M. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03672.x · Cited by 623

Flagged first, then by citations

Show all 59 references

Research works printed but not linked: 1

L Pasteur, J Joubert, Charbon et septicemie. Compt Rend Acad 85, 101–105 (1877).

Sorted by citations

Items 101–200 of 317

Metabolic Modeling of Cystic Fibrosis Airway Communities Predicts Mechanisms of Pathogen Dominance
Henson, M. A., Orazi, G., Phalak, P., & O’Toole, G. A. (2019) · mSystems · doi:10.1128/msystems.00026-19 · Cited by 46
Effect of Autoinducer-2 Quorum Sensing Inhibitor on Interspecies Quorum Sensing
Jiang, K., Xu, Y., Yuan, B., Yue, Y., Zhao, M., Luo, R., Wu, H., Wang, L., Zhang, Y., Xiao, J., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.791802 · Cited by 45
The interplay of Pseudomonas aeruginosa and Staphylococcus aureus in dual-species biofilms impacts development, antibiotic resistance and virulence of biofilms in in vitro wound infection models
Vestweber, P. K., Wächter, J., Planz, V., Jung, N., & Windbergs, M. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304491 · Cited by 52
Development of a Staphylococcus aureus reporter strain with click beetle red luciferase for enhanced in vivo imaging of experimental bacteremia and mixed infections
Miller, R. J., Crosby, H. A., Schilcher, K., Wang, Y., Ortines, R. V., Mazhar, M., Dikeman, D. A., Pinsker, B. L., Brown, I. D., Joyce, D. P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-52982-0 · Cited by 45
The evolution of virulence in Pseudomonas aeruginosa during chronic wound infection
Vanderwoude, J., Fleming, D. F., Azimi, S., Trivedi, U., Rumbaugh, K. P., & Diggle, S. P. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2020.2272 · Cited by 44
Self-citation
Pseudomonas aeruginosa reverse diauxie is a multidimensional, optimized, resource utilization strategy
McGill, S. L., Yung, Y. P., Hunt, K. A., Henson, M. A., Hanley, L., & Carlson, R. P. (2021) · Scientific Reports · doi:10.1038/s41598-020-80522-8 · Cited by 45
A multifunctional SERS sticky note for real-time quorum sensing tracing and inactivation of bacterial biofilms
Guo, J., Liu, Y., Chen, Y., Li, J., & Ju, H. (2018) · Chemical Science · doi:10.1039/c8sc02078g · Cited by 44
Decreased efficacy of antimicrobial agents in a polymicrobial environment
O’Brien, T. J., Figueroa, W., & Welch, M. (2022) · The ISME Journal · doi:10.1038/s41396-022-01218-7 · Cited by 43
Exposure to pairs of Aeromonas strains enhances virulence in the Caenorhabditis elegans infection model
Mosser, T., Talagrand-Reboul, É., Colston, S. M., Graf, J., Figueras, M. J., Jumas‐Bilak, E., & Lamy, B. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01218 · Cited by 42
Population dynamics and transcriptomic responses of Pseudomonas aeruginosa in a complex laboratory microbial community
Cheng, Y., Yam, J. K. H., Cai, Z., Ding, Y., Zhang, L., Deng, Y., & Yang, L. (2019) · npj Biofilms and Microbiomes · doi:10.1038/s41522-018-0076-z · Cited by 44
Antimicrobial Activity of Clinically Isolated Bacterial Species Against Staphylococcus aureus
Hardy, B. L., Bansal, G., Hewlett, K. H., Arora, A., Schaffer, S. D., Kamau, E. T., Bennett, J. W., & Merrell, D. S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02977 · Cited by 44
Harnessing bacterial interactions to manage infections: a review on the opportunistic pathogen Pseudomonas aeruginosa as a case example
Rezzoagli, C., Granato, E. T., & Kümmerli, R. (2020) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001134 · Cited by 43
Cystic Fibrosis Isolates of Pseudomonas aeruginosa Retain Iron-Regulated Antimicrobial Activity against Staphylococcus aureus through the Action of Multiple Alkylquinolones
Nguyen, A. T., Jones, J. W., Cámara, M., Williams, P. M., Kane, M. A., & Oglesby, A. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01171 · Cited by 43
Mycobacterium abscessus subsp. abscessus Is Capable of Degrading Pseudomonas aeruginosa Quinolone Signals
Birmes, F. S., Wolf, T., Kohl, T. A., Rüger, K., Bange, F. C., Kalinowski, J., & Fetzner, S. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00339 · Cited by 40
Addition of cariogenic pathogens to complex oral microflora drives significant changes in biofilm compositions and functionalities
Liu, Y., Daniel, S. G., Kim, H., Koo, H., Korostoff, J. M., Teles, F., Bittinger, K. L., & Hwang, G. (2023) · Microbiome · doi:10.1186/s40168-023-01561-7 · Cited by 41
Global transcriptome responses including small RNAs during mixed‐species interactions with methicillin‐resistant Staphylococcus aureus and Pseudomonas aeruginosa
Miller, C. L., Laar, T. A. V., Chen, T., Karna, S. L. R., Chen, P., You, T., & Leung, K. P. (2016) · MicrobiologyOpen · doi:10.1002/mbo3.427 · Cited by 41
The role of 2,4-dihydroxyquinoline (DHQ) in Pseudomonas aeruginosa pathogenicity
Gruber, J. D., Chen, W., Parnham, S. R., Beauchesne, K. R., Moeller, P. D. R., Flume, P. A., & Zhang, Y. (2016) · PeerJ · doi:10.7717/peerj.1495 · Cited by 38
New Methods, New Concepts: What Can Be Applied to Freshwater Periphyton?
Gubelit, Y. I., & Grossart, H. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01275 · Cited by 36
Milieu matters: An in vitro wound milieu to recapitulate key features of, and probe new insights into, mixed-species bacterial biofilms
Kadam, S., Vandana, M., Dhekane, R., Bhide, D., Ugale, R., Tikhole, U., & Kaushik, K. S. (2021) · Biofilm · doi:10.1016/j.bioflm.2021.100047 · Cited by 37
Metabolism and Pathogenicity ofPseudomonas aeruginosaInfections in the Lungs of Individuals with Cystic Fibrosis
Palmer, G. C., & Whiteley, M. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mbp-0003-2014 · Cited by 37
Self-citation
Interactions between bacterial surface and nanoparticles govern the performance of “chemical nose” biosensors
Verma, M. S., Wei, S., Rogowski, J. L., Tsuji, J. M., Chen, P., Lin, C., Jones, L., & Gu, F. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.04.024 · Cited by 36
Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation
Thornton, C. S., Acosta, N., Surette, M. G., & Parkins, M. D. (2022) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piac036 · Cited by 37
Staphylococcus aureus Inhibits IL-8 Responses Induced by Pseudomonas aeruginosa in Airway Epithelial Cells
Chekabab, S. M., Silverman, R. J., LaFayette, S. L., Luo, Y., Rousseau, S., & Nguyen, D. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137753 · Cited by 38
Pseudomonas aeruginosa GroEL Stimulates Production of PTX3 by Activating the NF-κB Pathway and Simultaneously Downregulating MicroRNA-9
Shin, H., Jeon, J., Lee, J., Jin, S., & Ha, U. (2016) · Infection and Immunity · doi:10.1128/iai.00935-16 · Cited by 34
Presence of P seudomonas aeruginosa influences biofilm formation and surface protein expression of S taphylococcus aureus
Kumar, A., & Ting, Y. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12890 · Cited by 37
Cyanide Toxicity to Burkholderia cenocepacia Is Modulated by Polymicrobial Communities and Environmental Factors
Bernier, S. P., Workentine, M. L., Li, X., Magarvey, N. A., O’Toole, G. A., & Surette, M. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00725 · Cited by 34
Insights into host–pathogen interactions from state‐of‐the‐art animal models of respiratory Pseudomonas aeruginosa infections
Lorenz, A., Pawar, V., Häußler, S., & Weiß, S. (2016) · FEBS Letters · doi:10.1002/1873-3468.12454 · Cited by 34
Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition
Wong, J. J., Ho, F. K., Choo, P. Y., Chong, K. K. L., Ho, C. M. B., Neelakandan, R., Keogh, D., Barkham, T., Chen, J. L., Liu, C., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010766 · Cited by 35
Urinary Catheters Coated with a Novel Biofilm Preventative Agent Inhibit Biofilm Development by Diverse Bacterial Uropathogens
Navarro, S., Sherman, E. G., Colmer‐Hamood, J. A., Nelius, T., Myntti, M. F., & Hamood, A. N. (2022) · Antibiotics · doi:10.3390/antibiotics11111514 · Cited by 38
Tobramycin-Treated Pseudomonas aeruginosa PA14 Enhances Streptococcus constellatus 7155 Biofilm Formation in a Cystic Fibrosis Model System
Price, K. E., Naimie, A. A., Griffin, E. F., Bay, C., & O’Toole, G. A. (2015) · Journal of Bacteriology · doi:10.1128/jb.00705-15 · Cited by 32
Inhibition of Mixed Biofilms of Candida albicans and Staphylococcus aureus by β-Caryophyllene-Gold Nanoparticles
Khan, F., Tabassum, N., Jeong, G., Jung, W., & Kim, Y. (2023) · Antibiotics · doi:10.3390/antibiotics12040726 · Cited by 32
The cystic fibrosis microbiome in an ecological perspective and its impact in antibiotic therapy
Magalhães, A. P., Azevedo, N. F., Pereira, M. O., & Lopes, S. P. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-7177-x · Cited by 35
The demographic determinants of human microbiome health
Estrela, S., Whiteley, M., & Brown, S. P. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.11.005 · Cited by 31
Self-citation
Systematic identification of molecular mediators of interspecies sensing in a community of two frequently coinfecting bacterial pathogens
Zarrella, T. M., & Khare, A. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001679 · Cited by 31
Pathogen-pathogen interactions during co-infections
Ferreira, R. B. R., Antunes, L. C. M., & Sal‐Man, N. (2025) · The ISME Journal · doi:10.1093/ismejo/wraf104 · Cited by 34
The expanding horizon of alkyl quinolone signalling and communication in polycellular interactomes
Reen, F. J., McGlacken, G. P., & O’Gara, F. (2018) · FEMS Microbiology Letters · doi:10.1093/femsle/fny076 · Cited by 30
Pseudomonas aeruginosa Quorum-Sensing and Type VI Secretion System Can Direct Interspecific Coexistence During Evolution
Zhao, K., Du, L., Lin, J., Yuan, Y., Wang, X., Yue, B., Wang, X., Guo, Y., Chu, Y., & Zhou, Y. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02287 · Cited by 30
MWCNTs/PVA Hydrogel-Modified Electrochemical Sensors for Ex Vivo and In Vivo Detection of Pyocyanin Biomarker for Pseudomonas aeruginosa Wound Infection
Thirabowonkitphithan, P., Phuengmaung, P., Leelahavanichkul, A., & Laiwattanapaisal, W. (2023) · ACS Applied Electronic Materials · doi:10.1021/acsaelm.2c01396 · Cited by 29
Wounds and the Microbiota: The Healing Interplay Between Host and Microbial Communities
Al-Taweel, R., Hammad, A. S., Tajammul, A., Crovella, S., & Al‐Asmakh, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311365 · Cited by 35
Potential Contributions of Anaerobes in Cystic Fibrosis Airways
Thornton, C. S., & Surette, M. G. (2020) · Journal of Clinical Microbiology · doi:10.1128/jcm.01813-19 · Cited by 29
Minimalist Tetrazine N-Acetyl Muramic Acid Probes for Rapid and Efficient Labeling of Commensal and Pathogenic Peptidoglycans in Living Bacterial Culture and During Macrophage Invasion
Hillman, A. S., Hyland, S. N., Wodzanowski, K. A., Moore, D. L., Ratna, S., Jemas, A., Sandles, L.-M. D., Chaya, T. R., Ghosh, A., Fox, J. M., et al. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c13644 · Cited by 26
Combinatorial Drug Therapy for Controlling Pseudomonas aeruginosa and Its Association With Chronic Condition of Diabetic Foot Ulcer
Srivastava, P., & Karthikeyan, S. (2019) · The International Journal of Lower Extremity Wounds · doi:10.1177/1534734619873785 · Cited by 28
Mixed Populations and Co-Infection: Pseudomonas aeruginosa and Staphylococcus aureus
Camus, L., Briaud, P., Vandenesch, F., Doléans-Jordheim, A., & Moreau, K. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-08491-1_15 · Cited by 28
P. aeruginosa interactions with other microbes in biofilms during co-infection
Oliveira, M., Cunha, E. S., Tavares, L. M., & Serrano, I. D. (2023) · AIMS Microbiology · doi:10.3934/microbiol.2023032 · Cited by 31
Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa
Pajon, C., Fortoul, M. C., Diaz-Tang, G., Meneses, E. M., Kalifa, A. R., Sevy, E., Mariah, T., Toscan, B., Marcelin, M., Hernandez, D. M., et al. (2023) · eLife · doi:10.7554/elife.83664 · Cited by 28
Drosophila melanogaster as a polymicrobial infection model for Pseudomonas aeruginosa and Staphylococcus aureus
Lee, Y. J., Jang, H., Chung, I.-Y., & Cho, Y. (2018) · The Journal of Microbiology · doi:10.1007/s12275-018-8331-9 · Cited by 27
T6SS and ExoA of flesh-eating Aeromonas hydrophila in peritonitis and necrotizing fasciitis during mono- and polymicrobial infections
Fernández-Bravo, A., Kilgore, P. B., Andersson, J. A., Blears, E. E., Figueras, M. J., Hasan, N. A., Colwell, R. R., Sha, J., & Chopra, A. K. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914395116 · Cited by 27
Pathogenicity and virulence of Pseudomonas aeruginosa : Recent advances and under-investigated topics
Swain, J. E. V., Askenasy, I., Nazeer, R. R., Ho, P.-M., Labrini, E., Mancini, L., Xu, Q., Hollendung, F., Sheldon, I., Dickson, C., et al. (2025) · Virulence · doi:10.1080/21505594.2025.2503430 · Cited by 31
Discerning the role of polymicrobial biofilms in the ascent, prevalence, and extent of heteroresistance in clinical practice
Lopes, S. P., Jorge, P., Sousa, A. M., & Pereira, M. O. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1863329 · Cited by 27
Surfaceome and Exoproteome Dynamics in Dual-Species Pseudomonas aeruginosa and Staphylococcus aureus Biofilms
Reigada, I., San-Martin-Galindo, P., Gilbert-Girard, S., Chiaro, J., Cerullo, V., Savijoki, K., Nyman, T. A., Fallarero, A., & Miettinen, I. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.672975 · Cited by 26
Strain-specific interspecies interactions between co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization
Gomes-Fernandes, M., Gómez, A.-C., Bravo, M., Huedo, P., Coves, X., Prat, C., Gibert, I., Lacoma, A., & Yero, D. (2022) · Scientific Reports · doi:10.1038/s41598-022-07018-5 · Cited by 26
Bacterial cell‐to‐cell signaling promotes the evolution of resistance to parasitic bacteriophages
Moreau, P. R., Diggle, S. P., & Friman, V. (2017) · Ecology and Evolution · doi:10.1002/ece3.2818 · Cited by 26
2,3‐Butanediol catabolism in Pseudomonas aeruginosa PAO1
Liu, Q., Liu, Y., Kang, Z., Xiao, D., Gao, C., Xu, P., & Ma, C. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14332 · Cited by 26
Viable but non‐cultivable state: a strategy for Staphylococcus aureus survivable in dual‐species biofilms with Pseudomonas aeruginosa ?
Magalhães, A. P., Grainha, T., Sousa, A. M., França, Â., Cerca, N., & Pereira, M. O. (2021) · Environmental Microbiology · doi:10.1111/1462-2920.15734 · Cited by 28
Electrochemical Detection of Pseudomonas aeruginosa in Polymicrobial Environments
Santiveri, C. R., Sismaet, H. J., Kimani, M. K., & Goluch, E. D. (2018) · ChemistrySelect · doi:10.1002/slct.201800569 · Cited by 24
Interpreting and Designing Microbial Communities for Bioprocess Applications, from Components to Interactions to Emergent Properties
Beck, A. E., Hunt, K. A., Bernstein, H. C., & Carlson, R. P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-444-63475-7.00015-7 · Cited by 25
From molecules to multispecies ecosystems: the roles of structure in bacterial biofilms
Gordon, V. D., Bakhtiari, L. A., & Kovach, K. N. (2019) · Physical Biology · doi:10.1088/1478-3975/ab1384 · Cited by 25
Pseudomonas aeruginosa Pathogenicity and Its Interaction with Other Microorganisms During the Skin Wound Healing Process
Yamberla, I., Pupiales, C., Chiliquinga, A. J., Sulca-Villamarín, T., Plasencia, A., Cabrera, F., Díaz, R., Caicedo, A., & Barba, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199677 · Cited by 27
Biotic inactivation of the P seudomonas aeruginosa quinolone signal molecule
Soh, E. Y., Chhabra, S. R., Halliday, N., Heeb, S., Müller, C., Birmes, F. S., Fetzner, S., Cámara, M., Chan, K., & Williams, P. M. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12857 · Cited by 23
A post-planktonic era of in vitro infectious models: issues and changes addressed by a clinically relevant wound like media
Trivedi, U., Madsen, J. S., Rumbaugh, K. P., Wolcott, R. D., Burmølle, M., & Sørensen, S. J. (2016) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1252312 · Cited by 26
Self-citation
Genetic and environmental determinants of surface adaptations in Pseudomonas aeruginosa
Ambreetha, S., & Singh, V. (2023) · Microbiology · doi:10.1099/mic.0.001335 · Cited by 22
In vitro efficacy of a non‐instrumentation technique to remove intracanal multispecies biofilm
Ordinola‐Zapata, R., Mansour, D. E., Saavedra, F. M., Staley, C. M., Chen, R., & Fok, A. S. L. (2022) · International Endodontic Journal · doi:10.1111/iej.13706 · Cited by 22
Pseudomonas aeruginosa behaviour in polymicrobial communities: The competitive and cooperative interactions conducting to the exacerbation of infections
Al-Wrafy, F. A., Reem, A., Noman, E. A., Al-Gheethi, A. A. S., & Mutahar, M. (2023) · Microbiological Research · doi:10.1016/j.micres.2022.127298 · Cited by 22
Single-Cell Control of Initial Spatial Structure in Biofilm Development Using Laser Trapping
Hutchison, J., Rodesney, C., Kaushik, K. S., Le, H. H., Hurwitz, D. A., Irie, Y., & Gordon, V. D. (2014) · Langmuir · doi:10.1021/la500128y · Cited by 21
Regulation of acetyl-CoA synthetase transcription by the CrbS/R two-component system is conserved in genetically diverse environmental pathogens
Jacob, K. M., Rasmussen, A., Tyler, P. M., Servos, M. M., Sylla, M., Prado, C., Daniele, E., Sharp, J. S., & Purdy, A. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177825 · Cited by 22
A Continuous-Flow Model for in vitro Cultivation of Mixed Microbial Populations Associated With Cystic Fibrosis Airway Infections
O’Brien, T. J., & Welch, M. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02713 · Cited by 21
Burkholderia thailandensis Methylated Hydroxyalkylquinolines: Biosynthesis and Antimicrobial Activity in Cocultures
Klaus, J. R., Majerczyk, C. D., Moon, S., Eppler, N. A., Smith, S., Tuma, E., Groleau, M., Asfahl, K. L., Smalley, N. E., Hayden, H. S., et al. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.01452-20 · Cited by 22
Spoils of war: iron at the crux of clinical and ecological fitness of Pseudomonas aeruginosa
Nguyen, A. T., & Oglesby, A. G. (2015) · BioMetals · doi:10.1007/s10534-015-9848-6 · Cited by 23
N-Acetylglucosamine Inhibits LuxR, LasR and CviR Based Quorum Sensing Regulated Gene Expression Levels
Kimyon, Ö., Uluturk, Z. I., Nizalapur, S., Lee, M., Kutty, S. K., Beckmann, S., Kumar, N., & Manefield, M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01313 · Cited by 21
Can multi-species biofilms defeat antimicrobial surfaces on medical devices?
Ramstedt, M., & Burmølle, M. (2022) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2022.100370 · Cited by 21
Role of Pel and Psl polysaccharides in the response of Pseudomonas aeruginosa to environmental challenges: oxidative stress agents (UVA, H2O2, sodium hypochlorite) and its competitor Staphylococcus aureus
Grossich, R., Vilches, M. L., Costa, C. S., & Pezzoni, M. (2023) · Microbiology · doi:10.1099/mic.0.001301 · Cited by 21
Alteration of protein homeostasis mediates the interaction of Pseudomonas aeruginosa with Staphylococcus aureus
Yang, N., Cao, Q., Hu, S., Xu, C., Fan, K., Chen, F., Yang, C., Liang, H., Wu, M., Bae, T., et al. (2020) · Molecular Microbiology · doi:10.1111/mmi.14519 · Cited by 21
It is all about Location: How to Pinpoint Microorganisms and their Functions in Multispecies Biofilms
Costa, Â. M., Mergulhão, F. J., Briandet, R., & Azevedo, N. F. (2017) · Future Microbiology · doi:10.2217/fmb-2017-0053 · Cited by 21
Phenazines contribute to microbiome dynamics by targeting topoisomerase IV
Zhou, Y., Wang, H., Sun, J., Wicaksono, W. A., Liu, C., He, Y., Qin, Y., Berg, G., Li, L., Lin, H., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-025-02118-0 · Cited by 20
Clinical Insights into Pulmonary Exacerbations in Cystic Fibrosis from the Microbiome. What Are We Missing?
Whelan, F., & Surette, M. G. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201506-353aw · Cited by 20
Potential role of the antimicrobial peptide Tachyplesin III against multidrug-resistant P. aeruginosa and A. baumannii coinfection in an animal model
Qi, J., Gao, R., Liu, C., Shan, B., Gao, F., He, J., Yuan, M., Hanghang, X., Jin, S., & Ma, Y. (2019) · Infection and Drug Resistance · doi:10.2147/idr.s217020 · Cited by 20
Accepting higher morbidity in exchange for sacrificing fewer animals in studies developing novel infection-control strategies
Busscher, H. J., Woudstra, W., van Kooten, T. G., Jutte, P. C., Shi, L., Liu, J., Hinrichs, W. L. J., Frijlink, H. W., Shi, R., Liu, J., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119737 · Cited by 20
Pseudomonas aeruginosa DesB Promotes Staphylococcus aureus Growth Inhibition in Coculture by Controlling the Synthesis of HAQs
Kim, S., Yoon, Y., & Choi, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134624 · Cited by 21
Pseudomonas aeruginosa-dependent upregulation of TLR2 influences host responses to a secondaryStaphylococcus aureusinfection
Shin, H.-S., Lee, J., Paek, S., Jung, Y. W., & Ha, U. (2013) · Pathogens and Disease · doi:10.1111/2049-632x.12074 · Cited by 22
Chemically modified and inactivated bacteria enable intra-biofilm drug delivery and long-term immunity against implant infections
Yang, C., Saiding, Q., Chen, W., An, S., Zhao, S., Khan, M. M., Kong, N., Ge, M., Shi, J., Lin, H., et al. (2026) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01600-8 · Cited by 22
N-Acyl Homoserine Lactone-Mediated Quorum Sensing Regulates Species Interactions in Multispecies Biofilm Communities
Subramoni, S., Muzaki, M. Z. B. M., Booth, S. C., Kjelleberg, S. J., & Rice, S. A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.646991 · Cited by 21
Essential Fitness Repertoire of Staphylococcus aureus during Co-infection with Acinetobacter baumannii In Vivo
Li, G., Shen, W., Gong, Y., Li, M., Rao, X., Liu, Q., Yu, Y., Zhou, J., Zhu, K., Yuan, M., et al. (2022) · mSystems · doi:10.1128/msystems.00338-22 · Cited by 17
Feeding behaviour of Caenorhabditis elegans is an indicator of Pseudomonas aeruginosa PAO1 virulence
Lewenza, S., Charron‐Mazenod, L., Giroux, L., & Zamponi, A. (2014) · PeerJ · doi:10.7717/peerj.521 · Cited by 19
Cytotoxic rhamnolipid micelles drive acute virulence in Pseudomonas aeruginosa
Xu, Q., Kang, D., Meyer, M. D., Pennington, C. L., Gopal, C., Schertzer, J. W., & Kirienko, N. V. (2024) · Infection and Immunity · doi:10.1128/iai.00407-23 · Cited by 18
Metabolic modelling of chronic wound microbiota predicts mutualistic interactions that drive community composition
Phalak, P., & Henson, M. A. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14421 · Cited by 20
Formation of a biofilm matrix network shapes polymicrobial interactions
Wang, L., Wang, H., Zhang, H., & Wu, H. (2023) · The ISME Journal · doi:10.1038/s41396-023-01362-8 · Cited by 17
Escherichia coli exopolysaccharides disrupt Pseudomonas aeruginosa biofilm and increase its antibiotic susceptibility
Wan, C., Ju, X., Xu, D., Ou, J., Zhu, M., Lu, G., Li, K., Jiang, W. J., Li, C., Hu, X., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.07.028 · Cited by 17
Synthesis of antimicrobial glucosamides as bacterial quorum sensing mechanism inhibitors
Biswas, N. N., Yu, T. T., Kimyon, Ö., Nizalapur, S., Gardner, C. R., Manefield, M., Griffith, R., Black, D. S., & Kumar, N. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.12.024 · Cited by 17
Recapitulation of Polymicrobial Communities Associated with Cystic Fibrosis Airway Infections: A Perspective
O’Brien, T. J., & Welch, M. (2019) · Future Microbiology · doi:10.2217/fmb-2019-0200 · Cited by 16
ChpC controls twitching motility-mediated expansion of Pseudomonas aeruginosa biofilms in response to serum albumin, mucin and oligopeptides
Nolan, L. M., McCaughey, L. C., Merjane, J., Turnbull, L., & Whitchurch, C. B. (2020) · Microbiology · doi:10.1099/mic.0.000911 · Cited by 16
Impact of Peptidoglycan Recycling Blockade and Expression of Horizontally Acquired β-Lactamases on Pseudomonas aeruginosa Virulence
Barceló, I. M., Torrens, G., Escobar‐Salom, M., Jordana‐Lluch, E., Capó-Bauzá, M. M., Ramón-Pallín, C., García-Cuaresma, D., Fraile-Ribot, P. A., Mulet, X., Oliver, A., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02019-21 · Cited by 16
Small flies to tackle big questions: assaying complex bacterial virulence mechanisms usingDrosophila melanogaster
Fauvarque, M. (2014) · Cellular Microbiology · doi:10.1111/cmi.12292 · Cited by 18
Development of a mixed‐species biofilm model and its virulence implications in device related infections
Naing, T., Wallace, L. A., Wibaux, A., Boote, N., & Jenkins, A. T. A. (2018) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34103 · Cited by 16
Functional Characterization of the agtABCD and agtSR Operons for 4-Aminobutyrate and 5-Aminovalerate Uptake and Regulation in Pseudomonas aeruginosa PAO1
Chou, H. T., Li, J.-Y., & Lu, C. (2013) · Current Microbiology · doi:10.1007/s00284-013-0446-y · Cited by 15
Bacterial tweets and podcasts #signaling#eavesdropping#microbialfightclub
Michie, K. L., Cornforth, D. M., & Whiteley, M. (2016) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2016.05.005 · Cited by 15
Self-citation
How can the cystic fibrosis respiratory microbiome influence our clinical decision-making?
Rogers, G. B., Bruce, K. D., & Hoffman, L. R. (2017) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000419 · Cited by 15
Pseudomonas aeruginosa auto inducer3-oxo-C12-HSL exerts bacteriostatic effect and inhibits Staphylococcus epidermidis biofilm
Singh, P. K., Yadav, V. K., Kalia, M., Dohare, S., Sharma, D., & Agarwal, V. K. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.08.009 · Cited by 14
Effect of glucose on growth and co-culture of Staphylococcus aureus and Pseudomonas aeruginosa in artificial sputum medium
Vasiljevs, S., Gupta, A., & Baines, D. L. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21469 · Cited by 15
Acquisition of T6SS Effector TseL Contributes to the Emerging of Novel Epidemic Strains of Pseudomonas aeruginosa
Ren, A., Jia, M., Liu, J., Zhou, T., Wu, L., Dong, T., Cai, Z., Qu, J., Liu, Y., Yang, L., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.03308-22 · Cited by 13
The role of Staphylococcus aureus in cystic fibrosis pathogenesis and clinico-microbiological interactions
Sheykhsaran, E., Abbasi, A., Memar, M. Y., Ghotaslou, R., Baghi, H. B., Mazraeh, F. N., Laghousi, D., & Sadeghi, J. (2024) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2024.116294 · Cited by 12

Authors: Korgaonkar, A., Trivedi, U., Rumbaugh, K. P., & Whiteley, M.
Affiliations: The University of Texas at Austin (US)
Texas Tech University (US)
ORCID: Korgaonkar, Aishwarya
Trivedi, Urvish
Rumbaugh, Kendra P.
Whiteley, Marvin
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2012-12-31
Volume: 110
Issue: 3
Pages: 1059-1064
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1214550110
PMC: PMC3549110
OpenAlex: W2062817953
Cited by: 315
References: 59
Citations by year: 2026: 14 · 2025: 24 · 2024: 16 · 2023: 27 · 2022: 26 · 2021: 23 · 2020: 24 · 2019: 26 · 2018: 21 · 2017: 21 · 2016: 24 · 2015: 32 · 2014: 28 · 2013: 9
FWCI: 8.88
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI075068)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Keywords: Pseudomonas aeruginosa, co-infection, bacterial synergy, peptidoglycan sensing, Gram-positive bacteria, extracellular virulence factors, lytic activity, community-based surveillance
MeSH terms: Animals, Base Sequence, Disease Models, Animal, DNA, Bacterial, Drosophila melanogaster, Female, Genes, Bacterial, Humans, Male, Mutation, Peptidoglycan, Pseudomonas aeruginosa, Pseudomonas Infections, Staphylococcal Infections, Staphylococcus aureus, Virulence, Mice, Quorum Sensing, Coinfection

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Community surveillance enhances Pseudomonas aeruginosa virulence during polymicrobial infection

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks