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Cited by 637

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis

Open access
Ju, Chuanli, Yoon, Gyeong Mee, Shemansky, Jennifer Marie, Lin, David Y., Ying, Z. Irene, Chang, Jianhong, Garrett, Wesley M., Kessenbrock, Mareike, Groth, Georg, Tucker, Mark L., Cooper, Bret, Kieber, Joseph J., Chang, Caren·2012·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1214848109
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Abstract

The gaseous phytohormone ethylene C 2 H 4 mediates numerous aspects of growth and development. Genetic analysis has identified a number of critical elements in ethylene signaling, but how these elements interact biochemically to transduce the signal from the ethylene receptor complex at the endoplasmic reticulum (ER) membrane to transcription factors in the nucleus is unknown. To close this gap in our understanding of the ethylene signaling pathway, the challenge has been to identify the target of the CONSTITUTIVE TRIPLE RESPONSE1 (CTR1) Raf-like protein kinase, as well as the molecular events surrounding ETHYLENE-INSENSITIVE2 (EIN2), an ER membrane-localized Nramp homolog that positively regulates ethylene responses. Here we demonstrate that CTR1 interacts with and directly phosphorylates the cytosolic C-terminal domain of EIN2. Mutations that block the EIN2 phosphorylation sites result in constitutive nuclear localization of the EIN2 C terminus, concomitant with constitutive activation of ethylene responses in Arabidopsis . Our results suggest that phosphorylation of EIN2 by CTR1 prevents EIN2 from signaling in the absence of ethylene, whereas inhibition of CTR1 upon ethylene perception is a signal for cleavage and nuclear localization of the EIN2 C terminus, allowing the ethylene signal to reach the downstream transcription factors. These findings significantly advance our understanding of the mechanisms underlying ethylene signal transduction.

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Metadata

Authors
Ju, C., Yoon, G. M., Shemansky, J. M., Lin, D. Y., Ying, Z. I., Chang, J., Garrett, W. M., Kessenbrock, M., Groth, G., Tucker, M. L., Cooper, B., Kieber, J. J., & Chang, C.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2012-11-06
Volume
109
Issue
47
Pages
19486-19491
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1214848109
OpenAlex
W2085512599
Cited by
637
References
30
FWCI
49.02
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis. https://app.cochat.ai/papers/10.1073/pnas.1214848109
The paper
Ju, C., Yoon, G. M., Shemansky, J. M., Lin, D. Y., Ying, Z. I., Chang, J., Garrett, W. M., Kessenbrock, M., Groth, G., Tucker, M. L., Cooper, B., Kieber, J. J., & Chang, C. (2012). CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1214848109

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.