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Cited by 256

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Long-range protein–water dynamics in hyperactive insect antifreeze proteins

Open access
Meister, Konrad, Ebbinghaus, Simon, Xu, Yao, Duman, John G., DeVries, Arthur, Gruebele, Martin, Leitner, David M., Havenith, Martina·2013·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1214911110
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Abstract

Antifreeze proteins (AFPs) are specific proteins that are able to lower the freezing point of aqueous solutions relative to the melting point. Hyperactive AFPs, identified in insects, have an especially high ability to depress the freezing point by far exceeding the abilities of other AFPs. In previous studies, we postulated that the activity of AFPs can be attributed to two distinct molecular mechanisms: ( i ) short-range direct interaction of the protein surface with the growing ice face and ( ii ) long-range interaction by protein-induced water dynamics extending up to 20 Å from the protein surface. In the present paper, we combine terahertz spectroscopy and molecular simulations to prove that long-range protein–water interactions make essential contributions to the high antifreeze activity of insect AFPs from the beetle Dendroides canadensis . We also support our hypothesis by studying the effect of the addition of the osmolyte sodium citrate.

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Metadata

Authors
Meister, K., Ebbinghaus, S., Xu, Y., Duman, J. G., DeVries, A., Gruebele, M., Leitner, D. M., & Havenith, M.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2012-12-31
Volume
110
Issue
5
Pages
1617-1622
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1214911110
OpenAlex
W2117957872
Cited by
256
References
45
FWCI
13.94
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Long-range protein–water dynamics in hyperactive insect antifreeze proteins. https://app.cochat.ai/papers/10.1073/pnas.1214911110
The paper
Meister, K., Ebbinghaus, S., Xu, Y., Duman, J. G., DeVries, A., Gruebele, M., Leitner, D. M., & Havenith, M. (2013). Long-range protein–water dynamics in hyperactive insect antifreeze proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1214911110

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.