Cited by 172Alzheimer's disease research and treatmentsCell death mechanisms and regulationNeuroinflammation and Neurodegeneration Mechanisms

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Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

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Xie, Hong, Hou, Steven, Jiang, Jun, Sekutowicz, Maria, Kelly, Jonathan, Bacskai, Brian J.·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1217938110PMC PMC3651444

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Abstract

Neuronal loss is the ultimate outcome in a variety of neurodegenerative diseases and central nerve system disorders. Understanding the sequelae of events that leads to cell death would provide insight into neuroprotective approaches. We imaged neurons in the living brain of a mouse model of Alzheimer's disease that overexpresses mutant human amyloid precursor protein and presenilin 1 and followed the death of individual neurons in real time. This mouse model exhibited limited neurodegeneration and atrophy, but we were able to identify a small fraction of vulnerable cells that would not have been detectable by using standard approaches. By exploiting a genetically encoded reporter of oxidative stress, we identified susceptible neurons by their increased redox potential. The oxidative stress was most dramatic in neurites near plaques, propagated to cell bodies, and preceded activation of caspases that led to cell death within 24 h. Thus, local oxidative stress surrounding plaques contributes to long-range toxicity and selective neuronal death in Alzheimer's disease.

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Additional file 1 of [18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 mice
Hsieh, C.-J., Hou, C., Zhu, Y., Lee, J. Y., Kohli, N., Gallagher, E. P., Xu, K., Lee, H. S., Li, S., McManus, M. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.20390984
Additional file 1 of Label-free vibrational imaging of different Aβ plaque types in Alzheimer’s disease reveals sequential events in plaque development
Röhr, D., Boon, B. D. C., Schuler, M., Kremer, K., Hoozemans, J. J. M., Bouwman, F. H., El‐Mashtoly, S. F., Nabers, A., Großerueschkamp, F., Rozemüller, A. J. M., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13467957
Additional file 2 of Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease
Calvo-Rodríguez, M., Kharitonova, E. K., Snyder, A. C., Hou, S. S., Sanchez-Mico, M. V., Das, S., Fan, Z., Shirani, H., Nilsson, K. P. R., Serrano‐Pozo, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25026030
Additional file 1 of Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease
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Authors: Xie, H., Hou, S., Jiang, J., Sekutowicz, M., Kelly, J., & Bacskai, B. J.
Affiliations: Massachusetts General Hospital (US)
Tsinghua University (CN)
ORCID: Xie, Hong
Sekutowicz, Maria
Bacskai, Brian J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-04-22
Volume: 110
Issue: 19
Pages: 7904-7909
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1217938110
PMC: PMC3651444
OpenAlex: W2086831255
Cited by: 172
References: 29
Citations by year: 2026: 8 · 2025: 13 · 2024: 15 · 2023: 11 · 2022: 12 · 2021: 14 · 2020: 16 · 2019: 17 · 2018: 11 · 2017: 8 · 2016: 11 · 2015: 13 · 2014: 14 · 2013: 8
FWCI: 10.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG024688, R01AG024688)
National Institute of Biomedical Imaging and Bioengineering (EB 000768, R01EB000768)
National Center for Research Resources (S10RR025645)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, amyloid plaques, oxidative stress, neuronal cell death, presenilin 1, amyloid precursor protein, caspase activation, neurodegeneration, neuroprotection
MeSH terms: Alzheimer Disease, Animals, Atrophy, Gene Expression Regulation, Image Processing, Computer-Assisted, Mice, Transgenic, Neurons, Oxidation-Reduction, Time Factors, Cell Death, Oxidative Stress, Caspases, Green Fluorescent Proteins, Mice, Plaque, Amyloid

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Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

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