The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions
Open accessAbstract
Significance: Although genetic studies have uncovered critical functions of GDF9 and BMP15 in female reproduction, many genetic and physiologic data for these ligands remain perplexing. Here we establish that mouse and human GDF9:BMP15 heterodimers are the most biopotent regulators of ovarian granulosa cell functions. Moreover, GDF9:BMP15 heterodimers require a unique signaling complex that includes the type 2 receptor BMPR2, an ALK4/5/7 type 1 kinase receptor, and an ALK6 type 1 co-receptor. GDF9:BMP15 binding to this complex stimulates phosphorylation of SMAD2/3. Our findings explain intraspecies and interspecies functions of these oocyte-synthesized proteins and have key implications for the regulation of female fertility.
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Cited by
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321
Structural insights into BMP receptors: Specificity, activation and inhibition
Yadin, D., Knaus, P., & Mueller, T. D. (2016) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.11.005 · Cited by 221
Ciccarelli, E. J., Wing, Z., Bendelstein, M., Johal, R. K., Singh, G., Monas, A., & Savage-Dunn, C. (2024) · PLOS Genetics · doi:10.1371/journal.pgen.1011324 · Cited by 7
Metadata
- Authors
- Peng, J., Li, Q., Wigglesworth, K., Rangarajan, A., Kattamuri, C., Peterson, R. T., Eppig, J. J., Thompson, T. B., & Matzuk, M. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-02-04
- Volume
- 110
- Issue
- 8
- Pages
- E776-85
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2010067285
- Cited by
- 321
- References
- 1
- FWCI
- 26.79
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions. https://app.cochat.ai/papers/10.1073/pnas.1218020110
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- Peng, J., Li, Q., Wigglesworth, K., Rangarajan, A., Kattamuri, C., Peterson, R. T., Eppig, J. J., Thompson, T. B., & Matzuk, M. M. (2013). Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1218020110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
