Cited by 150Neurobiology and Insect Physiology ResearchNeuroendocrine regulation and behaviorAnimal Behavior and Reproduction

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

A neuropeptide circuit that coordinates sperm transfer and copulation duration in Drosophila

Open access

Tayler, Timothy D., Pacheco, Diego A., Hergarden, Anne C., Murthy, Mala, Anderson, David J.·2012·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1218246109PMC PMC3528491

Open this paper in CoChat — free account

Abstract

Innate behaviors are often executed in concert with accompanying physiological programs. How this coordination is achieved is poorly understood. Mating behavior and the transfer of sperm and seminal fluid (SSFT) provide a model for understanding how concerted behavioral and physiological programs are coordinated. Here we identify a male-specific neural pathway that coordinates the timing of SSFT with the duration of copulation behavior in Drosophila. Silencing four abdominal ganglion (AG) interneurons (INs) that contain the neuropeptide corazonin (Crz) both blocked SSFT and substantially lengthened copulation duration. Activating these Crz INs caused rapid ejaculation in isolated males, a phenotype mimicked by injection of Crz peptide. Crz promotes SSFT by activating serotonergic (5-HT) projection neurons (PNs) that innervate the accessory glands. Activation of these PNs in copulo caused premature SSFT and also shortened copulation duration. However, mating terminated normally when these PNs were silenced, indicating that SSFT is not required for appropriate copulation duration. Thus, the lengthened copulation duration phenotype caused by silencing Crz INs is independent of the block to SSFT. We conclude that four Crz INs independently control SSFT and copulation duration, thereby coupling the timing of these two processes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.1218246109

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Spatiotemporal Rescue of Memory Dysfunction in Drosophila
McGuire, S. E., Le, P. T., Osborn, A. J., Matsumoto, K., & Davis, R. L. (2003) · Science · doi:10.1126/science.1089035 · Cited by 1,338
Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging
Akerboom, J., Chen, T., Wardill, T. J., Tian, L., Marvin, J. S., Mutlu, S., Calderón, N. C., Esposti, F., Borghuis, B. G., Sun, X. R., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2601-12.2012 · Cited by 1,289
An internal thermal sensor controlling temperature preference in Drosophila
Hamada, F. N., Rosenzweig, M. R., Kang, K., Pulver, S. R., Ghezzi, A., Jegla, T. J., & Garrity, P. (2008) · Nature · doi:10.1038/nature07001 · Cited by 1,089
Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development
Lee, T., & Luo, L. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01791-4 · Cited by 928
Male Accessory Gland Secretions: Modulators of Female Reproductive Physiology and Behavior
Gillott, C. (2002) · Annual Review of Entomology · doi:10.1146/annurev.ento.48.091801.112657 · Cited by 824
Altered Electrical Properties inDrosophilaNeurons Developing without Synaptic Transmission
Baines, R., Uhler, J. P., Thompson, A., Sweeney, S. T., & Bate, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01523.2001 · Cited by 618
Tokens of love: Functions and regulation of drosophila male accessory gland products
Wolfner, M. F. (1997) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(96)00084-7 · Cited by 584
Neural Circuitry that Governs Drosophila Male Courtship Behavior
Stockinger, P., Kvitsiani, D., Rotkopf, S., Tirián, L., & Dickson, B. J. (2005) · Cell · doi:10.1016/j.cell.2005.04.026 · Cited by 560
fruitless Splicing Specifies Male Courtship Behavior in Drosophila
Demir, E., & Dickson, B. J. (2005) · Cell · doi:10.1016/j.cell.2005.04.027 · Cited by 496
tudor, a gene required for assembly of the germ plasm in Drosophila melanogaster
Boswell, R. E. (1985) · Cell · doi:10.1016/0092-8674(85)90015-7 · Cited by 409

Show all 33 references

Research works printed but not linked: 1

A Bairati, Structure and ultrastructure of the male reproductive system of Drosophila melanogaster Meig. 2. The genital duct and accessory glands. Monit. Zoolog. Ital. 2, 105–182 (1968).

Sorted by citations

The genomes of two key bumblebee species with primitive eusocial organization
Sadd, B. M., Barribeau, S. M., Bloch, G., de Graaf, D. C., Dearden, P. K., Elsik, C. G., Gadau, J. R., Grimmelikhuijzen, C. J. P., Hasselmann, M., Lozier, J. D., et al. (2015) · Genome biology · doi:10.1186/s13059-015-0623-3 · Cited by 390
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Nässel, D. R., & Zandawala, M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.003 · Cited by 373
Tachykinin-Expressing Neurons Control Male-Specific Aggressive Arousal in Drosophila
Asahina, K., Watanabe, K., Duistermars, B. J., Hoopfer, E. D., González, C. R., Eyjólfsdóttir, E., Perona, P., & Anderson, D. J. (2014) · Cell · doi:10.1016/j.cell.2013.11.045 · Cited by 363
Self-citation
Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship
Inagaki, H. K., Jung, Y., Hoopfer, E. D., Wong, A. M., Mishra, N., Lin, J. Y., Tsien, R. Y., & Anderson, D. J. (2014) · Nature Methods · doi:10.1038/nmeth.2765 · Cited by 321
Self-citation
Neuropeptides as Regulators of Behavior in Insects
Schoofs, L., LOOF, A. D., & Hiel, M. B. V. (2016) · Annual Review of Entomology · doi:10.1146/annurev-ento-031616-035500 · Cited by 269
A genetic, genomic, and computational resource for exploring neural circuit function
Davis, F. P., Nern, A., Picard, S., Reiser, M. B., Rubin, G. M., Eddy, S. R., & Henry, G. L. (2020) · eLife · doi:10.7554/elife.50901 · Cited by 268
P1 interneurons promote a persistent internal state that enhances inter-male aggression in Drosophila
Hoopfer, E. D., Jung, Y., Inagaki, H., Rubin, G. M., & Anderson, D. J. (2015) · eLife · doi:10.7554/elife.11346 · Cited by 242
Self-citation
A journey into the world of insect lipid metabolism
Toprak, U., Hegedus, D. D., Doğan, C., & Güney, G. (2020) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.21682 · Cited by 222
Fat Body—Multifunctional Insect Tissue
Skowronek, P., Wójcik, Ł., & Strachecka, A. (2021) · Insects · doi:10.3390/insects12060547 · Cited by 204
The Neuropeptide Corazonin Controls Social Behavior and Caste Identity in Ants
Gospočić, J., Shields, E. J., Glastad, K. M., Lin, Y., Penick, C. A., Yan, H., Mikheyev, A. S., Linksvayer, T. A., Garcia, B. A., Berger, S. L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.014 · Cited by 189
A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord
Allen, A. M., Neville, M. C., Birtles, S., Croset, V., Treiber, C. D., Waddell, S., & Goodwin, S. F. (2020) · eLife · doi:10.7554/elife.54074 · Cited by 177
The Role of Peptide Hormones in Insect Lipid Metabolism
Toprak, U. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00434 · Cited by 179
A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila
Oh, Y., Lai, J. S.-Y., Mills, H. J., Erdjument‐Bromage, H., Giammarinaro, B., Saadipour, K., Wang, J. G., Farhan, A., Neubert, T. A., & Suh, G. S. B. (2019) · Nature · doi:10.1038/s41586-019-1675-4 · Cited by 174
Natalisin, a tachykinin-like signaling system, regulates sexual activity and fecundity in insects
Jiang, H., Lkhagva, A., Daubnerová, I., Chae, H.-S., Šimo, L., Jung, S.-H., Yoon, Y. K., Lee, N.-R., Seong, J. Y., Žitňan, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310676110 · Cited by 144
Dopaminergic Circuitry Underlying Mating Drive
Zhang, S. X., Rogulja, D., & Crickmore, M. A. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.020 · Cited by 147
Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia
Hauser, F., & Grimmelikhuijzen, C. J. P. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.07.009 · Cited by 140
Systemic corazonin signalling modulates stress responses and metabolism in Drosophila
Kubrak, O. I., Lushchak, O. V., Zandawala, M., & Nässel, D. R. (2016) · Open Biology · doi:10.1098/rsob.160152 · Cited by 134
The Drosophila seminal proteome and its role in postcopulatory sexual selection
Wigby, S., Brown, N. C., Allen, S. E., Misra, S., Sitnik, J. L., Sepil, I., Clark, A. G., & Wolfner, M. F. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2020.0072 · Cited by 138
A PDF/NPF Neuropeptide Signaling Circuitry of Male Drosophila melanogaster Controls Rival-Induced Prolonged Mating
Kim, W. J., Jan, L. Y., & Jan, Y. N. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.034 · Cited by 123
Divergent allocation of sperm and the seminal proteome along a competition gradient in Drosophila melanogaster
Hopkins, B. R., Sepil, I., Thézénas, M., Craig, J. F., Miller, T., Charles, P. D., Fischer, R., Kessler, B. M., Bretman, A. J., Pizzari, T., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906149116 · Cited by 130
Substrates for Neuronal Cotransmission With Neuropeptides and Small Molecule Neurotransmitters in Drosophila
Nässel, D. R. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00083 · Cited by 119
The evolution and nomenclature of GnRH-type and corazonin-type neuropeptide signaling systems
Zandawala, M., Tian, S., & Elphick, M. R. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.06.007 · Cited by 105
Diverse roles for theDrosophilafructose sensor Gr43a
Miyamoto, T., & Amrein, H. (2013) · Fly · doi:10.4161/fly.27241 · Cited by 105
Opposing Dopaminergic and GABAergic Neurons Control the Duration and Persistence of Copulation in Drosophila
Crickmore, M. A., & Vosshall, L. B. (2013) · Cell · doi:10.1016/j.cell.2013.09.055 · Cited by 97
Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila
Wu, S., Guo, C., Zhao, H., Sun, M., Chen, J., Han, C., Peng, Q., Qiao, H., Peng, P., Liu, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12758-6 · Cited by 84
Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions
Nässel, D. R., & Zandawala, M. (2022) · Open Biology · doi:10.1098/rsob.220174 · Cited by 85
Light, heat, action: neural control of fruit fly behaviour
Owald, D., Lin, S., & Waddell, S. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0211 · Cited by 83
Sex differences in Drosophila behavior: qualitative and quantitative dimorphism
Asahina, K. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.04.004 · Cited by 86
The Corazonin-PTTH Neuronal Axis Controls Systemic Body Growth by Regulating Basal Ecdysteroid Biosynthesis in Drosophila melanogaster
Imura, E., Shimada‐Niwa, Y., Nishimura, T., Hückesfeld, S., Schlegel, P., Ohhara, Y., Kondo, S., Tanimoto, H., Cardona, A., Pankratz, M. J., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.03.050 · Cited by 86
A neuroendocrine pathway modulating osmotic stress in Drosophila
Zandawala, M., Nguyen, T., Balanyà-Segura, M., Johard, H. A. D., Amcoff, M., Wegener, C., Paluzzi, J.-P. V., & Nässel, D. R. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009425 · Cited by 77
Neural circuitry coordinating male copulation
Pavlou, H. J., Lin, A. C., Neville, M. C., Nojima, T., Diao, F., Chen, B. E., White, B. H., & Goodwin, S. F. (2016) · eLife · doi:10.7554/elife.20713 · Cited by 76
A Neural Circuit Encoding the Experience of Copulation in Female Drosophila
Shao, L., Chung, P., Wong, A. M., Siwanowicz, I., Kent, C. F., Long, X., & Heberlein, U. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.009 · Cited by 73
Ejaculation Induced by the Activation of Crz Neurons Is Rewarding to Drosophila Males
Zer-Krispil, S., Zak, H., Shao, L., Ben-Shaanan, S., Tordjman, L., Bentzur, A., Shmueli, A., & Shohat-Ophir, G. (2018) · Current Biology · doi:10.1016/j.cub.2018.03.039 · Cited by 70
Neprilysins: An Evolutionarily Conserved Family of Metalloproteases That Play Important Roles in Reproduction in Drosophila
Sitnik, J. L., Francis, C., Hens, K., Huybrechts, R., Wolfner, M. F., & Callaerts, P. (2014) · Genetics · doi:10.1534/genetics.113.160945 · Cited by 65
Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in Platynereis
Andreatta, G., Broyart, C., Borghgraef, C., Vadiwala, K., Kozin, V., Polo, A., Bileck, A., Beets, I., Schoofs, L., Gerner, C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910262116 · Cited by 61
The Drosophila Accessory Gland as a Model for Prostate Cancer and Other Pathologies
WILSON, C. G., Leiblich, A., Goberdhan, D. C. I., & Hamdy, F. C. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.06.001 · Cited by 60
Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons
Garbe, D. S., Vigderman, A. S., Moscato, E. H., Dove, A. E., Vecsey, C. G., Kayser, M. S., & Sehgal, A. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416668048 · Cited by 57
Cholecystokinin/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression
Nässel, D. R., & Wu, S. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04214-4 · Cited by 60
Invertebrate Gonadotropin-Releasing Hormone-Related Peptides and Their Receptors: An Update
Sakai, T., Shiraishi, A., Kawada, T., Matsubara, S., Aoyama, M., & Satake, H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00217 · Cited by 57
CaMKII Measures the Passage of Time to Coordinate Behavior and Motivational State
Thornquist, S. C., Langer, K., Zhang, S. X., Rogulja, D., & Crickmore, M. A. (2019) · Neuron · doi:10.1016/j.neuron.2019.10.018 · Cited by 56
Social attraction in Drosophila is regulated by the mushroom body and serotonergic system
Sun, Y., Qiu, R., Li, X., Cheng, Y., Gao, S., Kong, F., Liu, L., & Zhu, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-19102-3 · Cited by 55
Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa
Li, S., Hauser, F., Skadborg, S. K., Nielsen, S. V., Kirketerp-Møller, N., & Grimmelikhuijzen, C. J. P. (2016) · Scientific Reports · doi:10.1038/srep32789 · Cited by 49
Neurons for Ejaculation and Factors Affecting Ejaculation
Soni, K. K., Jeong, H., & Jang, S. (2022) · Biology · doi:10.3390/biology11050686 · Cited by 49
Regulation of Ethanol-Related Behavior and Ethanol Metabolism by the Corazonin Neurons and Corazonin Receptor in Drosophila melanogaster
Sha, K., Choi, S., Im, J., Lee, G., LOEFFLER, F. E., & Park, J. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087062 · Cited by 45
Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila
Lee, S. H., Cho, E., Yoon, S., Kim, Y., & Kim, E. Y. (2021) · Communications Biology · doi:10.1038/s42003-021-02219-6 · Cited by 38
Regulation of Dense-Core Granule Replenishment by Autocrine BMP Signalling in Drosophila Secondary Cells
Redhai, S., Hellberg, J. E. E. U., Wainwright, M. S., Perera, S., Castellanos, F., Kroeger, B., Gandy, C., Leiblich, A., Corrigan, L., Hilton, T., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006366 · Cited by 38
Tissue-specific transcriptome analyses provide new insights into GPCR signalling in adult Schistosoma mansoni
Hahnel, S. R., Wheeler, N. J., Lu, Z., Wangwiwatsin, A., McVeigh, P., Maule, A. G., Berriman, M., Day, T. A., Ribeiro, P., & Grevelding, C. G. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006718 · Cited by 38
Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes
Palmateer, C. M., Artikis, C., Brovero, S. G., Friedman, B., Gresham, A., & Arbeitman, M. N. (2023) · eLife · doi:10.7554/elife.78511 · Cited by 41
Mating reconciles fitness and fecundity by switching diet preference in flies
Liu, C. F., Tian, N., Chang, P., & Zhang, W. (2024) · Nature Communications · doi:10.1038/s41467-024-54369-w · Cited by 39
Sleep pressure accumulates in a voltage-gated lipid peroxidation memory
Rorsman, H. O., Müller, M. A., Liu, P. Z., Sanchez, L. G., Kempf, A., Gerbig, S., Spengler, B., & Miesenböck, G. (2025) · Nature · doi:10.1038/s41586-025-08734-4 · Cited by 34
Distributed physiology and the molecular basis of social life in eusocial insects
Friedman, D., Johnson, B. R., & Linksvayer, T. A. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104757 · Cited by 35
RPamide neuropeptides NLP-22 and NLP-2 act through GnRH-like receptors to promote sleep and wakefulness in C. elegans
der Auwera, P. V., Frooninckx, L., Buscemi, K., Vance, R. T., Watteyne, J., Mirabeau, O., Temmerman, L., Haes, W. D., Fancsalszky, L., GOTTSCHALK, A. R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66536-2 · Cited by 28
Sexually satiated male uses gustatory-to-neuropeptide integrative circuits to reduce time investment for matingPreprint
Kim, W. J., Lee, S. G., Auge, A.-C., Jan, L. Y., & Jan, Y. N. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/088724 · Cited by 29
Molecular Mechanisms of Sexually Dimorphic Nervous System Patterning in Flies and Worms
Goodwin, S. F., & Hobert, O. (2021) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120319-115237 · Cited by 29
Daily rewiring of a neural circuit generates a predictive model of environmental light
Song, B. J., Sharp, S. J., & Rogulja, D. (2021) · Science Advances · doi:10.1126/sciadv.abe4284 · Cited by 29
A rapid and bidirectional reporter of neural activity reveals neural correlates of social behaviors in Drosophila
Bonheur, M., Swartz, K. J., Metcalf, M. G., Wen, X., Zhukovskaya, A., Mehta, A., Connors, K. E., Barasch, J. G., Jamieson, A. R., Martin, K. C., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01357-w · Cited by 27
Neuropeptide-mediated synaptic plasticity regulates context-dependent mating behaviors in Drosophila
Zhang, T., Wu, Z., Song, Y., Ryu, T. H., Zhang, X., Li, W., Sun, Y., Wong, K., Schweizer, J., Nguyen, K.-N. H., et al. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003330 · Cited by 20
Molecular characterizations of natalisin and its roles in modulating mating in the oriental fruit fly, Bactrocera dorsalis (Hendel)
Gui, S., Jiang, H. ‐., Liu, X., Xu, L., & Wang, J. ‐. (2016) · Insect Molecular Biology · doi:10.1111/imb.12274 · Cited by 25
Biochemical evidence accumulates across neurons to drive a network-level eruption
Thornquist, S. C., Pitsch, M. J., Auth, C. S., & Crickmore, M. A. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.12.029 · Cited by 26
Investigation of Drosophila fruitless neurons that express Dpr/DIP cell adhesion molecules
Brovero, S. G., Fortier, J. C., Hu, H., Lovejoy, P. C., Newell, N. R., Palmateer, C. M., Tzeng, R.-Y., Lee, P.-T., Zinn, K., & Arbeitman, M. N. (2021) · eLife · doi:10.7554/elife.63101 · Cited by 25
Dopamine biases decisions by limiting temporal integration
Gautham, A. K., Miner, L. E., Franco, M. N., Thornquist, S. C., & Crickmore, M. A. (2024) · Nature · doi:10.1038/s41586-024-07749-7 · Cited by 24
Corazonin signaling is required in the male for sperm transfer in the oriental fruit fly Bactrocera dorsalis
Hou, Q.-L., Chen, E.-H., Jiang, H.-B., Yu, S.-F., Yang, P.-J., Liu, X.-Q., Park, Y., Wang, J.-J., & Smagghe, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00660 · Cited by 23
A brief history of insect neuropeptide and peptide hormone research
Nässel, D. R. (2024) · Cell and Tissue Research · doi:10.1007/s00441-024-03936-0 · Cited by 23
Multiple neuropeptides produced by sex-specific neurons control activity of the male accessory glands and gonoducts in the silkworm Bombyx mori
Čižmár, D., Roller, L., Pillerová, M., Sláma, K., & Žitňan, D. (2019) · Scientific Reports · doi:10.1038/s41598-019-38761-x · Cited by 22
Transcriptional regulation in model organisms: recent progress and clinical implications
Tang, J., Xu, Z., Huang, L., Luo, H., & Zhu, X. M. (2019) · Open Biology · doi:10.1098/rsob.190183 · Cited by 22
Neural circuit mechanisms encoding motivational states in Drosophila
Lee, S., & Wu, M. N. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.05.002 · Cited by 22
Failure to mate enhances investment in behaviors that may promote mating reward and impairs the ability to cope with stressors via a subpopulation of Neuropeptide F receptor neurons
Ryvkin, J., Omesi, L., Kim, Y., Levi, M., Pozeilov, H., Barak-Buchris, L., Agranovich, B., Abramovich, I., Gottlieb, E., Jacob, A., et al. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011054 · Cited by 20
Drosophila Corazonin Neurons as a Hub for Regulating Growth, Stress Responses, Ethanol-Related Behaviors, Copulation Persistence and Sexually Dimorphic Reward Pathways
Khan, Z., Tondravi, M., Oliver, R., & Vonhoff, F. (2021) · Journal of Developmental Biology · doi:10.3390/jdb9030026 · Cited by 20
Corazonin signaling modulates the synthetic activity of male accessory gland in Grapholita molesta
Cheng, J., Zhao, P., Zhu, L. D., Zhu, F., Tian, Z., Shen, Z., Liu, X., & Liu, X. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.025 · Cited by 18
Characterization of the Sexually Dimorphic fruitless Neurons That Regulate Copulation Duration
Jois, S., Chan, Y. B., Fernandez, M. P., & Leung, A. K.-W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00780 · Cited by 19
Genetic screening reveals cone cell-specific factors as common genetic targets modulating rival-induced prolonged mating in male Drosophila melanogaster
Sun, Y., Zhang, X., Wu, Z., Li, W., & Kim, W. J. (2024) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkae255 · Cited by 17
Mating pair drives aggressive behavior in female Drosophila
Gaspar, M., Dias, S., & Vasconcelos, M. L. (2022) · Current Biology · doi:10.1016/j.cub.2022.09.009 · Cited by 19
Hybrid male sterility between Drosophila willistoni species is caused by male failure to transfer sperm during copulation
Civetta, A., & Gaudreau, C. (2015) · BMC Evolutionary Biology · doi:10.1186/s12862-015-0355-8 · Cited by 17
GnRH-Related Neurohormones in the Fruit Fly Drosophila melanogaster
Ben-Menahem, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22095035 · Cited by 16
Sex peptide regulates female receptivity through serotoninergic neurons in Drosophila
Yang, Y. T., Hu, S. W., Li, X., Sun, Y., He, P., Kohlmeier, K. A., & Zhu, Y. (2023) · iScience · doi:10.1016/j.isci.2023.106123 · Cited by 18
A sexually transmitted sugar orchestrates reproductive responses to nutritional stress
Kim, S.-J., Lee, K., Park, S. H., Yang, T., Song, I., Rai, F., Hoshino, R., Yun, M., Zhang, C., Kim, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52807-3 · Cited by 14
Timing the Juvenile-Adult Neurohormonal Transition: Functions and Evolution
Barredo, C. G., Gil-Martí, B., Deveci, D., Romero, N. M., & Martín, F. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.602285 · Cited by 13
Functional characterization and related evolutionary implications of invertebrate gonadotropin-releasing hormone/corazonin in a well-established model species
Fodor, I., Svigruha, R., Bozsó, Z., Tóth, G. K., Osugi, T., Yamamoto, T., Satake, H., & Pirger, Z. (2021) · Scientific Reports · doi:10.1038/s41598-021-89614-5 · Cited by 13
The gonadotropin-releasing hormone (GnRH) superfamily across Pancrustacea/Tetraconata: A role in metabolism?
Marco, H. G., Glendinning, S., Ventura, T., & GÄde, G. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112238 · Cited by 13
The role of the neuropeptide [His7]-corazonin on phase-related characteristics in the Central American locust
Foquet, B., & Song, H. (2021) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2021.104244 · Cited by 13
insomniac links the development and function of a sleep-regulatory circuit
Li, Q., Jang, H., Lim, K. Y., Lessing, A., & Stavropoulos, N. (2021) · eLife · doi:10.7554/elife.65437 · Cited by 13
Corazonin mediates photoperiodically induced diapause in the bean bug Riptortus pedestris
Xi, J., Hamanaka, Y., & Shiga, S. (2025) · Journal of Experimental Biology · doi:10.1242/jeb.250528 · Cited by 12
Neural Circuits: Anatomy of a Sexual Behavior
Krupp, J. J., & Levine, J. D. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.009 · Cited by 12
Corazonin Neurons Contribute to Dimorphic Ethanol Sedation Sensitivity in Drosophila melanogaster
Oyeyinka, A., Kansal, M., O’Sullivan, S. M., Gualtieri, C., Smith, Z. M., & Vonhoff, F. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.702901 · Cited by 12
Piezo-mediated mechanosensation contributes to stabilizing copulation posture and reproductive success in Drosophila males
Yamanouchi, H. M., Tanaka, R., & Kamikouchi, A. (2023) · iScience · doi:10.1016/j.isci.2023.106617 · Cited by 12
Control of Male and Female Fertility by the Netrin Axon Guidance Genes
Newquist, G., Hogan, J., Walker, K. L., Lamanuzzi, M., Bowser, M., & Kidd, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072524 · Cited by 12
Non-invasive manipulation of Drosophila behavior by two-photon excited red-activatable channelrhodopsin
Hsiao, P.-Y., Tsai, C.-L., Chen, M.-C., Lin, Y.-Y., Yang, S., & Chiang, A. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.004344 · Cited by 11
Serotonergic neuronal death and concomitant serotonin deficiency curb copulation ability of Drosophila platonic mutants
Yılmazer, Y., Koganezawa, M., Sato, K., Jin-hua, X., & Yamamoto, D. (2016) · Nature Communications · doi:10.1038/ncomms13792 · Cited by 11
ER-Ca2+ sensor STIM regulates neuropeptides required for development under nutrient restriction in Drosophila
Megha, M., Wegener, C., & Hasan, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219719 · Cited by 11
Insect Mating Behaviors: A Review of the Regulatory Role of Neuropeptides
Ombuya, A., Guo, J., & Liu, W. (2025) · Insects · doi:10.3390/insects16050506 · Cited by 10
Mating-induced Ecdysone in the testis disrupts soma-germline contacts and stem cell cytokinesis
Roach, T. V., & Lenhart, K. F. (2024) · Development · doi:10.1242/dev.202542 · Cited by 10
Stressed Out Insects II. Physiology, Behavior, and Neuroendocrine Circuits Mediating Stress Responses
Johnson, E. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00038-9 · Cited by 11
Sex and Death: Identification of Feedback Neuromodulation Balancing Reproduction and Survival
Gao, C., Guo, C., Peng, Q., Cao, J., Shohat-Ophir, G., Liu, D., & Pan, Y. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00604-5 · Cited by 9
A heart releasing neuropeptide that synchronizes brain-heart regulation during courtship behaviorPreprint
Li, H., Cheng, S., Niu, Y., Diao, T., Zhang, Q., & Zhang, W. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.31.646145 · Cited by 8
Insects as a New Complex Model in Hormonal Basis of Obesity
Walkowiak‐Nowicka, K., Chowański, S., Urbański, A., & Marciniak, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011066 · Cited by 8
Functional characterization of insect-specific RabX6 of Bombyx mori
Uno, T., Ozakiya, Y., Furutani, M., Sakamoto, K., Uno, Y., Kajiwara, H., Kanamaru, K., & Mizoguchi, A. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1710-9 · Cited by 7
Mating duration of male Drosophila melanogaster – A novel genetic model to study interval timing function of human brain
Wu, Z., Shao, J., Gill, R., & Kim, W. J. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106294 · Cited by 6
A corazonin G protein-coupled receptor gene in the tick Ixodes scapularis yields two splice variants, each coding for a specific corazonin receptor
Hauser, F., Pallesen, M., Lehnhoff, J., Li, S., Lind, A., & Grimmelikhuijzen, C. J. P. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.04.087 · Cited by 6
Peer-induced quiescence of male Drosophila melanogaster following copulation
Lynn, K., Ichinose, T., & Tanimoto, H. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1414029 · Cited by 5
Damage to the behavior and physiological functions of Apis mellifera (Hymenoptera: Apidae) by monocrotaline via the modulation of tryptophan metabolism and the corazonin receptor
Qi, H., Chi, X., Zhang, W., Song, H., Wang, Y., Liu, Z., Wang, H., & Xu, B. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.175931 · Cited by 5

Authors: Tayler, T. D., Pacheco, D. A., Hergarden, A. C., Murthy, M., & Anderson, D. J.
Affiliations: Princeton University (US)
California Institute of Technology (US)
ORCID: Pacheco, Diego A.
Murthy, Mala
Anderson, David J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2012-11-28
Volume: 109
Issue: 50
Pages: 20697-20702
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1218246109
PMC: PMC3528491
OpenAlex: W2150959561
Cited by: 150
References: 33
Citations by year: 2026: 11 · 2025: 23 · 2024: 13 · 2023: 6 · 2022: 11 · 2021: 16 · 2020: 15 · 2019: 12 · 2018: 9 · 2017: 3 · 2016: 13 · 2015: 7 · 2014: 5 · 2013: 6
FWCI: 2.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (5t32ns007251-22, 5f32ns058132-02)
National Institute on Drug Abuse (R01DA031389)
National Institute of Neurological Disorders and Stroke (T32 NS-007251, NS007251, F32 NS058132, 5F32NS058132)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords: sperm transfer, copulation duration, corazonin, neuropeptides, accessory glands, ejaculation, mating behavior
MeSH terms: Animals, Copulation, Drosophila melanogaster, Ejaculation, Female, Ganglia, Interneurons, Male, Models, Biological, Neuropeptides, Sperm Transport, Genes, Insect, Receptors, Neuropeptide, Drosophila Proteins, Animals, Genetically Modified

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A neuropeptide circuit that coordinates sperm transfer and copulation duration in Drosophila

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks