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An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long‐range loop formation

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CRISPR Double Cutting through the Labyrinthine Architecture of 3D Genomes

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Regulation of the cohesin-loading factor NIPBL: Role of the lncRNA NIPBL-AS1 and identification of a distal enhancer element

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Defining the multivalent functions of CTCF from chromatin state and three-dimensional chromatin interactions

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Developmental Control of NRAMP1 (SLC11A1) Expression in Professional Phagocytes

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Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development

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A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke

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May the Odds Be Ever in Your Favor: Non-deterministic Mechanisms Diversifying Cell Surface Molecule Expression

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RNA-binding proteins mediate the maturation of chromatin topology during differentiation

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Regulation of a Mammalian Gene Bearing a CpG Island Promoter and a Distal Enhancer

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A Compendium of G-Flipon Biological Functions That Have Experimental Validation

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Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance

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CTCF Mediates Dosage and Sequence-context-dependent Transcriptional Insulation through Formation of Local Chromatin DomainsPreprint

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PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes

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MeCP2 and CTCF: enhancing the cross-talk of silencers

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Gastrulation-stage gene expression in Nipbl +/− mouse embryos foreshadows the development of syndromic birth defects

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Tales from topographic oceans: topologically associated domains and cancer

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Cohesin promotes HSV-1 lytic transcription by facilitating the binding of RNA Pol II on viral genes

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3D genome organization in the central nervous system, implications for neuropsychological disorders

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Genetic enhancement of limb defects in a mouse model of Cornelia de Lange syndrome

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Identification of a distal enhancer of Ucp1 essential for thermogenesis and mitochondrial function in brown fat

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CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci

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Permeable TAD boundaries and their impact on genome‐associated functions

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Inferring CTCF-binding patterns and anchored loops across human tissues and cell types

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Emergence and influence of sequence bias in evolutionarily malleable, mammalian tandem arrays

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Characterization of a Single Genomic Locus Encoding the Clustered Protocadherin Receptor Diversity in Xenopus tropicalis

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MethNet: a robust approach to identify regulatory hubs and their distal targets from cancer data

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Cohesin and condensin regulate chromosome topology and play an essential role in maintaining pluripotency in embryonic stem cells

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Gene Clusters Reveal Fundamental Principles of Genome Folding and Transcriptional Regulation

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An Updated Overview of the Role of CYP450 during Xenobiotic Metabolization in Regulating the Acute Myeloid Leukemia Microenvironment

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Pushing the TAD boundary: Decoding insulator codes of clustered CTCF sites in 3D genomes

Huang, H., & Wu, Q. (2024) · BioEssays · doi:10.1002/bies.202400121 · Cited by 7

CCCTC-binding factor N-terminal domain regulates clustered protocadherin gene expression by enhancing cohesin processivity

Zhang, Y., & Wu, Q. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108337 · Cited by 7

Statistical Models for Detecting Differential Chromatin Interactions Mediated by a Protein

Niu, L., Li, G., & Lin, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097560 · Cited by 7

Polymorphic receptors: neuronal functions and molecular mechanisms of diversification

Schreiner, D., Nguyen, T.-M., & Scheiffele, P. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.02.009 · Cited by 7

Effect of Single-Residue Mutations on CTCF Binding to DNA: Insights from Molecular Dynamics Simulations

Mao, A. H., Chen, C., Portillo‐Ledesma, S., & Tamar Schlick, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076395 · Cited by 7

Protocadherins and Hypothalamic Development: Do They Play An Unappreciated Role?

Coughlin, G. M., & Kurrasch, D. M. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12280 · Cited by 6

Clustered Protocadherins

Mah, K. M., & Weiner, J. A. (2016) · Springer eBooks · doi:10.1007/978-4-431-56033-3_8 · Cited by 6

Zebrafish as a Model to Study Cohesin and Cohesinopathies

Muto, A., & Schilling, T. F. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6545-8_11 · Cited by 6

A negatively charged region within carboxy-terminal domain maintains proper CTCF DNA binding

Liu, L., Tang, Y., Zhang, Y., & Wu, Q. (2024) · iScience · doi:10.1016/j.isci.2024.111452 · Cited by 5

Cracking the cadherin codes that wire the nervous system

Gray, M. T., & Lefebvre, J. L. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103086 · Cited by 5

PCDHA1 High Expression is Associated With Poor Prognosis and Correlated With Immune Cell Infiltration in Breast Cancer

Du, J., & Wu, K. (2023) · Clinical Breast Cancer · doi:10.1016/j.clbc.2023.02.001 · Cited by 5

Three-dimensional genome architectural CCCTC-binding factor makes choice in duplicated enhancers at Pcdhα locus

Wu, Y., Jia, Z., Ge, X., & Wu, Q. (2020) · Science China Life Sciences · doi:10.1007/s11427-019-1598-4 · Cited by 5

Insulator Activities of Nucleosome-Excluding DNA Sequences without Bound Chromatin Looping Proteins

Matsushima, Y., Sakamoto, N., & Awazu, A. (2019) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.8b10518 · Cited by 4

Role of the Chromosome Architectural Factor SMCHD1 in X-Chromosome Inactivation, Gene Regulation, and Disease in Humans

Wang, C., Brand, H., Shaw, N. D., Talkowski, M. E., & Lee, J. T. (2019) · Genetics · doi:10.1534/genetics.119.302600 · Cited by 5

Epigenomic convergence of genetic and immune risk factors in neurodevelopmental disorder cortexPreprint

Vogel Ciernia, A., Laufer, B. I., Dunaway, K. W., Hwang, H., Mordaunt, C. E., Coulson, R. L., Yasui, D. H., & LaSalle, J. M. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/270827 · Cited by 6

Tuning cohesin trajectories enables differential readout of the Pcdhα cluster across neurons

Kiefer, L., Gaudin, S., Rajkumar, S. M., Servito, G., Langen, J., Mui, M. H., Nawsheen, S., & Canzio, D. (2024) · Science · doi:10.1126/science.adm9802 · Cited by 29

Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of Protocadherin-α gene expression

Monahan, K. D., Rudnick, N. D., Kehayova, P. D., Pauli, F., Newberry, K. M., Myers, R., & Maniatis, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205074109 · Cited by 155

The role of cohesin and DNA loop extrusion in the generation of single neuron identity

Kiefer, L. A., Maniatis, T., & Canzio, D. (2026) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2026.102445 · Cited by 3

Cohesin erases genomic-proximity biases to drive stochastic Protocadherin expression for proper neural wiringPreprint

Canzio, D., Kiefer, L., Servito, G. I., Rajkumar, S. M., Langen, J., Chiosso, A., Buckley, A., Elizabeth, S., Horta, A., & Mui, M. H. (2022) · Research Square · doi:10.21203/rs.3.rs-1278146/v1

The generation of a protocadherin cell-surface recognition code for neural circuit assembly

Canzio, D., & Maniatis, T. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.10.001 · Cited by 70