The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics
Open accessAbstract
Nanotechnology has allowed the construction of various nanostructures for applications, including biomedicine. However, a simple target-specific, economical, and biocompatible drug delivery platform with high maximum tolerated doses is still in demand. Here, we report aptamer-tethered DNA nanotrains (aptNTrs) as carriers for targeted drug transport in cancer therapy. Long aptNTrs were self-assembled from only two short DNA upon initiation by modified aptamers, which worked like locomotives guiding nanotrains toward target cancer cells. Meanwhile, tandem “boxcars” served as carriers with high payload capacity of drugs that were transported to target cells and induced selective cytotoxicity. aptNTrs enhanced maximum tolerated dose in nontarget cells. Potent antitumor efficacy and reduced side effects of drugs delivered by biocompatible aptNTrs were demonstrated in a mouse xenograft tumor model. Moreover, fluorophores on nanotrains and drug fluorescence dequenching upon release allowed intracellular signaling of nanotrains and drugs. These results make aptNTrs a promising targeted drug transport platform for cancer theranostics.
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Cites
Challenges and opportunities for structural DNA nanotechnology
Pinheiro, A. V., Han, D., Shih, W. M., & Yan, H. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.187 · Cited by 1,292
Cited by
DNA nanotechnology from the test tube to the cell
Chen, Y.-J., Groves, B., Muscat, R. A., & Seelig, G. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.195 · Cited by 594
Aptamer-based targeted therapy
Zhu, G., & Chen, X. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.005 · Cited by 522
Self-citationNoncanonical Self-Assembly of Multifunctional DNA Nanoflowers for Biomedical Applications
Zhu, G., Hu, R., Zhao, Z., Chen, Z., Zhang, X., & Tan, W. (2013) · Journal of the American Chemical Society · doi:10.1021/ja406115e · Cited by 429
Self-citationSupramolecular cancer nanotheranostics
Zhou, J., Rao, L., Yu, G., Cook, T. R., Chen, X., & Huang, F. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00011f · Cited by 411
Upconversion Luminescence-Activated DNA Nanodevice for ATP Sensing in Living Cells
Zhao, J., Gao, J., Xue, W., Di, Z., Xing, H., Lu, Y., & Li, L. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11161 · Cited by 361
Metadata
- Authors
- Zhu, G., Zheng, J., Song, E., Donovan, M., Zhang, K., Liu, C., & Tan, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-04-29
- Volume
- 110
- Issue
- 20
- Pages
- 7998-8003
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1973528774
- Cited by
- 546
- References
- 1
- FWCI
- 19.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhu, G., Zheng, J., Song, E., Donovan, M., Zhang, K., Liu, C., & Tan, W. (2013). Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1220817110
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