The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Noncanonical Self-Assembly of Multifunctional DNA Nanoflowers for Biomedical Applications
Open accessAbstract
DNA nanotechnology has been extensively explored to assemble various functional nanostructures for versatile applications. Mediated by Watson-Crick base-pairing, these DNA nanostructures have been conventionally assembled through hybridization of many short DNA building blocks. Here we report the noncanonical self-assembly of multifunctional DNA nanostructures, termed as nanoflowers (NFs), and the versatile biomedical applications. These NFs were assembled from long DNA building blocks generated via rolling circle replication (RCR) of a designer template. NF assembly was driven by liquid crystallization and dense packaging of building blocks, without relying on Watson-Crick base-pairing between DNA strands, thereby avoiding the otherwise conventional complicated DNA sequence design. NF sizes were readily tunable in a wide range, by simply adjusting such parameters as assembly time and template sequences. NFs were exceptionally resistant to nuclease degradation, denaturation, or dissociation at extremely low concentration, presumably resulting from the dense DNA packaging in NFs. The exceptional biostability is critical for biomedical applications. By rational design, NFs can be readily incorporated with myriad functional moieties. All these properties make NFs promising for versatile applications. As a proof-of-principle demonstration, in this study, NFs were integrated with aptamers, bioimaging agents, and drug loading sites, and the resultant multifunctional NFs were demonstrated for selective cancer cell recognition, bioimaging, and targeted anticancer drug delivery.
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Cites
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The Sequence of the Human Genome
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Aptamers evolved from live cells as effective molecular probes for cancer study
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Self-citationHuman Genome Sequencing Using Unchained Base Reads on Self-Assembling DNA Nanoarrays
Drmanac, R., Sparks, A. B., Callow, M. J., Halpern, A. L., Burns, N. L., Kermani, B. G., Carnevali, P., Nazarenko, I., Nilsen, G. B., Yeung, G., et al. (2010) · Science · doi:10.1126/science.1181498 · Cited by 1,212
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Cited by
Aptamer-based targeted therapy
Zhu, G., & Chen, X. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.08.005 · Cited by 522
Self-citationSupramolecular cancer nanotheranostics
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Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery
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Metadata
- Authors
- Zhu, G., Hu, R., Zhao, Z., Chen, Z., Zhang, X., & Tan, W.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-10-28
- Volume
- 135
- Issue
- 44
- Pages
- 16438-16445
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2157337481
- Cited by
- 429
- References
- 40
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- green
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