Cited by 268Ion channel regulation and functionCardiac electrophysiology and arrhythmiasIon Channels and Receptors

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Open access

McCormack, Ken, Santos, Sonia, Chapman, Mark L., Krafte, Douglas S., Marron, Brian E., West, Christopher W., Krambis, Michael J., Antonio, Brett M., Zellmer, Shannon G., Printzenhoff, David, Padilla, Karen M., Lin, Zhixin, Wagoner, P. Kay, Swain, Nigel A., Stupple, Paul A., de Groot, Marcel, Butt, Richard P., Castle, Neil A.·2013·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1220844110PMC PMC3718154

Open this paper in CoChat — free account Open PDF

Abstract

Significance: Voltage-gated sodium (Na v ) channels contribute to physiological and pathophysiological electrical signaling in nerve and muscle cells. Because Na v channel isoforms exhibit tissue-specific expression, subtype selective modulation of this channel family provides important drug development opportunities. However, most available Na v channel modulators are unable to distinguish between Na v channel subtypes, which limits their therapeutic utility because of cardiac or nervous system toxicity. This study describes a new class of subtype selective Na v channel inhibitors that interact with a region of the channel that controls voltage sensitivity. This interaction site may enable development of selective therapeutic interventions with reduced potential for toxicity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1073/pnas.1220844110

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A quantitative description of membrane current and its application to conduction and excitation in nerve
Hodgkin, A. L., & Huxley, A. F. (1952) · The Journal of Physiology · doi:10.1113/jphysiol.1952.sp004764 · Cited by 23,191
An SCN9A channelopathy causes congenital inability to experience pain
Cox, J. J., Reimann, F. M., Nicholas, A. K., Thornton, G., Roberts, E., Springell, K., Karbani, G., Jafri, H., Mannan, J., Raashid, Y., et al. (2006) · Nature · doi:10.1038/nature05413 · Cited by 1,605
The crystal structure of a voltage-gated sodium channel
Payandeh, J., Scheuer, T., Zheng, N., & Catterall, W. A. (2011) · Nature · doi:10.1038/nature10238 · Cited by 1,453
Molecular Determinants of State-Dependent Block of Na + Channels by Local Anesthetics
Ragsdale, D. S., McPhee, J. C., Scheuer, T., & Catterall, W. A. (1994) · Science · doi:10.1126/science.8085162 · Cited by 839
Voltage‐gated sodium channels at 60: structure, function and pathophysiology
Catterall, W. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.224204 · Cited by 728
Voltage-gated ion channels and gating modifier toxins
Catterall, W. A., Cestèle, S., Yarov-Yarovoy, V. M., Yu, F. H., Konoki, K., & Scheuer, T. (2006) · Toxicon · doi:10.1016/j.toxicon.2006.09.022 · Cited by 649
Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology
Catterall, W. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.021 · Cited by 570
Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels.
Ragsdale, D. S., McPhee, J. C., Scheuer, T., & Catterall, W. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9270 · Cited by 500
Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders
Mantegazza, M., Curia, G., Biagini, G., Ragsdale, D. S., & Avoli, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70059-4 · Cited by 462
Molecular Determinants of High Affinity Binding of α-Scorpion Toxin and Sea Anemone Toxin in the S3-S4 Extracellular Loop in Domain IV of the Na+ Channel α Subunit
Rogers, J. C., Qu, Y., Tanada, T. N., Scheuer, T., & Catterall, W. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.15950 · Cited by 411

Show all 46 references

Sorted by citations

Items 201–268 of 268

Development and characterization of pyridyl carboxamides as potent and highly selective Nav1.8 inhibitors
Poslusney, M. S., Ernst, G. E., Huang, Y., Gerlach, A. C., Chapman, M. L., Santos, S. F. G., & Barrow, J. C. (2024) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2024.130059 · Cited by 3
Self-citation
Structure–Activity Relationship Evaluation of Wasp Toxin β-PMTX Leads to Analogs with Superior Activity for Human Neuronal Sodium Channels
Garrison, C. E., Guan, W., Kato, M., Tamsett, T. J., Patel, T., Sun, Y., & Pathak, T. P. (2019) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.9b00415 · Cited by 3
Contribution of tetrodotoxin-sensitive, voltage-gated sodium channels (NaV1) to action potential discharge from mouse esophageal tension mechanoreceptors
Hadley, S. H., Patil, M. J., Pavelková, N., Kollárik, M., & Taylor‐Clark, T. E. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00199.2021 · Cited by 3
Technology, Science and Culture: A Global Vision, Volume IV
Hernández, L. R., & Meneses, M. A. S. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.105162 · Cited by 3
Equivalent excitability through different sodium channels and implications for the analgesic efficacy of selective drugsPreprint
Xie, Y., Yang, J., Ratté, S., & Prescott, S. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.04.510784 · Cited by 3
Thermally-induced neuronal plasticity that mediates heat tolerancePreprint
Ambroziak, W., Nencini, S., Pohle, J., Zuza, K., Pino, G., Lundh, S. H., Araujo-Sousa, C., Goetz, L. I. L., Schrenk-Siemens, K., Manoj, G., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.06.606929 · Cited by 3
NavDB: A Comprehensive Database for Voltage-Gated Sodium Channels Modulators and Targets
Wang, G., Yu, J., Chen, H., Luo, H. L., Pan, P., & Hou, T. (2026) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c02124 · Cited by 2
The Voltage-Dependent Sodium Channel Family
Zaleska, M., Salvage, S. C., Thompson, A. J., Namadurai, S., Huang, C. L.-H., Wilkinson, T. C. I., Cusdin, F. S., & Jackson, A. P. (2018) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190669164.013.14 · Cited by 2
Voltage-Gated Sodium Channels Mediating Conduction in Vagal Motor Fibers Innervating the Esophageal Striated Muscle
Pavelková, N., Brozmanová, M., Patil, M. J., & Kollárik, M. (2021) · Physiological Research · doi:10.33549/physiolres.934600 · Cited by 2
Ion Channels as Therapeutic Drug Targets
García, M. L., & Kaczorowski, G. J. (2021) · Wiley eBooks · doi:10.1002/0471266949.bmc255 · Cited by 2
Ion Channels
Townsend, C. Y. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.99998-5 · Cited by 1
Rate-dependent effects of state-specific sodium channel blockers in cardiac tissue: Insights from idealized models
Docken, S. S., Clancy, C. E., & Lewis, T. J. (2023) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2023.111595 · Cited by 1
Lidocaine potentiates thermal ablation in cholangiocarcinoma by modulating TRPV6-Driven Ca2+/PI3K/AKT/HSF-1 signaling pathway
Chen, P., Lin, Y., Xia, M., Feng, H.-B., Pan, Y., Tan, Y., Xu, M., Xing, X.-H., Yao, X., Hu, B., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218226 · Cited by 1
Discovery of a novel Nav1.5 inhibitor reducing cardiac conduction via structure-based virtual screening and assays
Wang, Y.-Y., Wang, G.-A., You, Q., Liu, Y.-F., Qu, W.-L., Chen, Y.-H., Mu, C.-Z., Zhou, X. J., Liu, M., Yang, W., et al. (2026) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01679-4 · Cited by 1
Ion Channel Drug Discovery: Future Perspectives
Gosling, M. (2014) · Royal Society of Chemistry eBooks · doi:10.1039/9781849735087-00341 · Cited by 1
An efficient stereoselective synthesis of aminocyclohexenes from 7-azanorbornenes via LiAlH 4 mediated tandem double bond migration-ring opening sequence
Yang, G., Wu, W., Li, Z., Chen, N., Qin, J., Hu, G., Zhang, Y., Li, J., & Chen, S. (2017) · Tetrahedron Letters · doi:10.1016/j.tetlet.2017.12.073 · Cited by 1
Effects of inhibition of Nav1.3, Nav1.7, and Nav1.8 channels on pain‐related behavior in Speke's hinge‐back tortoise ( Kinixys spekii )
Makau, C. M., Towett, P. K., Kanui, T. I., & Abelson, K. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25274 · Cited by 1
Membrane Physiology and Biophysics—What Remains to Be Done?
Fahlke, C. M. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00892 · Cited by 1
Preferential Pharmacological Inhibition of Nav1.6, but not Nav1.1, Abolishes Epileptiform Activity Induced by 4-AP in Mouse Cortical SlicesPreprint
Patel, R. R., Ping, X., Patel, S. R., McDermott, J. S., Krajewski, J. L., Chi, X. X., Nisenbaum, E. S., Jin, X., & Cummins, T. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.29.124693 · Cited by 1
Na V 1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8a N1768D/+ gain-of-function micePreprint
Johnson, J. P., Focken, T., Tari, P. K., Dubé, C. M., Goodchild, S. J., Andrez, J., Bankar, G. R., Burford, K., Chang, E., Chowdhury, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.03.551823 · Cited by 1
A painful tale about synthetic scorpion toxins
Salvatierra, J., & Bosmans, F. (2016) · Channels · doi:10.1080/19336950.2016.1163956
The role of organic anion‐transporting polypeptides and formulation in the clearance and distribution of a novel Nav1.7 channel blocker
Pike, A., Flanagan, N. J., Storer, R. I., Swain, N. A., & Tseng, E. (2018) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2156
Self-citation
Ion Channels
Townsend, C. Y. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00003-7
Technology, Science and Culture - A Global Vision, Volume IV
Hernández, L. R., & Meneses, M. A. S. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.101948
Equivalent excitability through different sodium channels and implications for the analgesic efficacy of selective drugsPreprint
Xie, Y., Yang, J., Ratté, S., & Prescott, S. A. (2023) · eLife · doi:10.7554/elife.90960.1
Equivalent excitability through different sodium channels and implications for the analgesic efficacy of selective drugsPreprint
Xie, Y., Yang, J., Ratté, S., & Prescott, S. A. (2024) · eLife · doi:10.7554/elife.90960.2
Epileptogenic Channelopathies Guide Design of NBI-921352, a Highly Isoform-Selective Inhibitor of NaV1.6
Johnson, J. P., Cutts, A. J., Empfield, J. R., & Cohen, C. J. (2024) · doi:10.1093/med/9780197549469.003.0072
Three-dimensional Quantitative Structure–activity Relationship, Molecular Docking and Absorption, Distribution, Metabolism, and Excretion Studies of Lidocaine Analogs Pertaining to Voltage-gated Sodium Channel Nav1.7 Inhibition for the Management of Neuropathic Pain
Sharma, S., Rana, P., Dhingra, N., & Kaur, T. (2025) · International Journal of Applied and Basic Medical Research · doi:10.4103/ijabmr.ijabmr_347_24
Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785Preprint
Zhang, S., Stix, R., Orabi, E. A., Bernhardt, N. A., & Faraldo-Gómez, J. (2026) · eLife · doi:10.7554/elife.101855.2
Rôles et régulations des canaux ioniques ASIC1b dans la douleur
Verkest, C. (2019) · theses.fr (ABES) · doi:10.70675/db17aabazd726z4d22zb273zf58b049ba711
Evaluation multi-échelle de toxines de venins comme agents antinociceptifs potentiels
Gonçalves, T. C. (2018) · doi:10.70675/2b19e842z59c7z4fddz89dez56589d50b3bd
Contribution des propriétés bistables du réseau moteur lombaire au tonus postural et au rythme locomoteur : caractérisation des canaux ioniques sous-jacents
Drouillas, B. (2022) · theses.fr (ABES) · doi:10.70675/7b854bd7z9d6fz4915z92c6z237073fbb5a7
Voltage-gated sodium channels in pain: Which channels, which blockers, and where NaV1.7 fits
Sutemieva, J., & Sobenin, D. V. (2026) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2026.04.001
A small molecule voltage-sensor modulator enhances the function of the cardiac NaV1.5 channel
Domingos, G., Fehér, Á. M., Teshome, R. T., Husain, S., Papp, F., Amna, A. O., Bangera, K. C., Vizi, Z., Elian, R., Kovács, Z. M., et al. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119530
A Zebrafish Platform to Model Human SCN2A and SCN8A Epilepsy and Evaluate Anti-Seizure MedicationsPreprint
Milder, P. C., Cummins, T., & Marrs, J. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.21.733632
Discovery of thieno[2,3-d]pyrimidine derivatives as novel, orally bioavailable dual inhibitors of T-type calcium and voltage-gated sodium channels with antiepileptic efficacy
Wang, Y., Zheng, S., Xu, Z., Liu, X., Chen, Y., Cao, T., Wu, L., He, Z., Ge, Q., Ma, Y., et al. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.113142
Sodium ion channels as therapeutic targets in epilepsy: a drug discovery perspective
Kong, W., Lv, K., Gao, R., Liangju, H., Zhou, Y., Liu, X., Chen, D., Li, F., & Chen, W. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110297
Discovery of 1 H -Indole-3-Propionamide Derivatives as Potent, Selective and Orally Available NaV1.7 Inhibitors for Pain Treatment
Chen, K., He, X., Wang, G., Wu, H., Liu, X., Wang, L., Wu, Y., Liu, X., Shen, L., Gong, Y., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c00882
Ligand-based pharmacophore modeling for the discovery of NaV1.7 inhibitors
Piga, M., Lukacs, P., Pesti, K., Várady, G., Varga, Z., Zidar, N., & Tomašič, T. (2026) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-026-00898-z
Modulation of human dorsal root ganglion neuron excitability by Nav1.7 inhibitionPreprint
Fujita, A., Jo, S., Stewart, R. G., Osorno, T., Ferraiuolo, A., Carlin, K., & Bean, B. P. (2026) · eLife · doi:10.7554/elife.111490.2
Discovery of a Quinazoline-Based Nav1.7 Inhibitor with MicroED-Confirmed Absolute Configuration and Oral Efficacy in Rodent Models of Neuropathic Pain
Shim, J. H., Lim, P., Woo, S., Han, J., & Kim, H. S. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c02422
Nav1.3 inhibition confers neuroprotection in traumatic brain injury by attenuating neuroinflammation and neuronal cell death via NCOA4-associated ferritin turnover
Zhao, H., Liu, Z., Li, X.-M., Zhang, D., Liu, W., Liao, Z., Su, G.-J., Liu, Z., & Huang, X.-J. (2026) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2026.168498
BindingDB Entry 50000210: Benzoxazolinone aryl sulfonamides as potent, selective Na
BindingDB (2019) · UC San Diego · doi:10.7270/q2sn0cd7
BindingDB Entry 50000083: Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na
BindingDB (2019) · UC San Diego · doi:10.7270/q29025xb
BindingDB Entry 50006220: Recent progress in sodium channel modulators for pain.
BindingDB (2020) · UC San Diego · doi:10.7270/q2ks6vjm
BindingDB Entry 50018140: Inhibition of Na
BindingDB (2024) · UC San Diego · doi:10.7270/q22f7snd
BindingDB Entry 50000820: Discovery of non-zwitterionic aryl sulfonamides as Na
BindingDB (2020) · UC San Diego · doi:10.7270/q20v8g8n
BindingDB Entry 50045956: N-Aryl azacycles as novel sodium channel blockers.
BindingDB (2016) · UC San Diego · doi:10.7270/q2862j67
BindingDB Entry 50000661: Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na
BindingDB (2019) · UC San Diego · doi:10.7270/q21g0pqf
BindingDB Entry 50049251: Development of New Benzenesulfonamides As Potent and Selective Na
BindingDB (2019) · UC San Diego · doi:10.7270/q2057j69
BindingDB Entry 50023278: Development and characterization of pyridyl carboxamides as potent and highly selective Nav1.8 inhibitors.
BindingDB (2026) · UC San Diego · doi:10.7270/q27949kr
BindingDB Entry 50013623: Identification of aryl sulfonamides as novel and potent inhibitors of Na
BindingDB (2022) · UC San Diego · doi:10.7270/q2cj8j7b
BindingDB Entry 50002554: Peptide therapeutics from venom: Current status and potential.
BindingDB (2020) · UC San Diego · doi:10.7270/q2q52s8q
BindingDB Entry 50007324: Discovery of new indole-based acylsulfonamide Na
BindingDB (2021) · UC San Diego · doi:10.7270/q2k64nc8
BindingDB Entry 50047473: Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models.
BindingDB (2017) · UC San Diego · doi:10.7270/q2j1052w
BindingDB Entry 50022283: New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel.
BindingDB (2025) · UC San Diego · doi:10.7270/q2cz3cvk
BindingDB Entry 50001978: Highly potent and selective Na
BindingDB (2020) · UC San Diego · doi:10.7270/q25q4zn1
BindingDB Entry 50009923: Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors.
BindingDB (2021) · UC San Diego · doi:10.7270/q25q50kx
BindingDB Entry 50049276: Sulfonamides as Selective Na
BindingDB (2019) · UC San Diego · doi:10.7270/q2rj4ms7
BindingDB Entry 50006999: Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform Na
BindingDB (2021) · UC San Diego · doi:10.7270/q2m90czd
BindingDB Entry 50002996: Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNa
BindingDB (2020) · UC San Diego · doi:10.7270/q2bv7k92
BindingDB Entry 50001046: The discovery of benzoxazine sulfonamide inhibitors of Na
BindingDB (2020) · UC San Diego · doi:10.7270/q2h134h4
BindingDB Entry 50045228: Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels.
BindingDB (2016) · UC San Diego · doi:10.7270/q22b90p2
BindingDB Entry 50001982: Discovery of aminocyclohexene analogues as selective and orally bioavailable hNav1.7 inhibitors for analgesia.
BindingDB (2020) · UC San Diego · doi:10.7270/q2ns0xgw
BindingDB Entry 50002214: Discovery of morpholine-based aryl sulfonamides as Na
BindingDB (2020) · UC San Diego · doi:10.7270/q2jw8hg2
BindingDB Entry 50044660: The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7.
BindingDB (2016) · UC San Diego · doi:10.7270/q2ff3tx9
BindingDB Entry 50009631: Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na
BindingDB (2021) · UC San Diego · doi:10.7270/q2z32344
BindingDB Entry 50046558: Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.
BindingDB (2016) · UC San Diego · doi:10.7270/q2xs5x6p

Authors: McCormack, K., Santos, S., Chapman, M. L., Krafte, D. S., Marron, B. E., West, C. W., Krambis, M. J., Antonio, B. M., Zellmer, S. G., Printzenhoff, D., Padilla, K. M., Lin, Z., Wagoner, P. K., Swain, N. A., Stupple, P. A., de Groot, M., Butt, R. P., & Castle, N. A.
Affiliations: Pfizer (United States) (US)
Pfizer (United Kingdom) (GB)
Pfizer Ltd., Sandwich, Kent CT13 9NJ, United Kingdom
ORCID: McCormack, Ken
Santos, Sonia
Chapman, Mark L.
Krafte, Douglas S.
Lin, Zhixin
Swain, Nigel A.
Stupple, Paul A.
Butt, Richard P.
Castle, Neil A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2013-07
Volume: 110
Issue: 29
Pages: E2724-32
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1220844110
PMC: PMC3718154
OpenAlex: W1979671751
Cited by: 244
References: 46
Citations by year: 2026: 15 · 2025: 12 · 2024: 20 · 2023: 16 · 2022: 20 · 2021: 19 · 2020: 19 · 2019: 14 · 2018: 24 · 2017: 33 · 2016: 22 · 2015: 13 · 2014: 15 · 2013: 2
FWCI: 8.36
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: voltage-gated sodium channels, small molecule inhibitors, subtype selectivity, Nav1.3, Nav1.7, cardiac sodium channel, toxin binding site, alpha-scorpion toxin, species sensitivity, sodium channel inactivation
MeSH terms: Acetamides, Binding Sites, Humans, Molecular Sequence Data, Thiazoles, Sequence Alignment, Patch-Clamp Techniques, Inhibitory Concentration 50, Amino Acid Motifs, Electrophysiological Phenomena, HEK293 Cells, Voltage-Gated Sodium Channel Blockers, NAV1.3 Voltage-Gated Sodium Channel

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks