A quantitative description of membrane current and its application to conduction and excitation in nerve
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The Hodgkin-Huxley model describes how a neuron's membrane voltage evolves over time due to ionic currents.
“A classic example is the conductance-based Hodgkin–Huxley model (23), which describes how a neuron’s membrane voltage V evolves over time due to ionic currents (Equation 4).”
From Predictive coding and neurocomputational psychiatry: a mechanistic framework for understanding mental disorders (2026) · cites this paper as [23]
According to the standard 'Hodgkin-Huxley' model, biological neurons are 'integrate-and-fire' threshold logic devices in which multiple branched dendrites and a cell body (soma) receive and integrate synaptic inputs as membrane potentials.
“Similarly, according to the standard 'Hodgkin-Huxley' [35] model, biological neurons are 'integrate-and-fire' threshold logic devices in which multiple branched dendrites and a cell body (soma) receive and integrate synaptic inputs as membrane potentials (Fig. 1).”
From Consciousness in the universe (2014) · cites this paper as [35]
The Hodgkin-Huxley model was first described by Hodgkin and Huxley and modified by Abbott and Kepler.
“This model was first described in the seminal work by Hodgkin and Huxley, and modified by Abbot and Kepler59,60.”
From Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy (2018) · cites this paper as [60]
Consciousness is widely assumed in modern science and philosophy to arise from complex synaptic computations within neural networks, with brain neurons as fundamental units of information.
“The prevailing assumption in both modern science and philosophy is that consciousness arises from complex synaptic computations within neural networks, where brain neurons function as fundamental units of information [1,2].”
From Quantum Models of Consciousness from a Quantum Information Science Perspective (2025) · cites this paper as [2]
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- Authors
- Hodgkin, A. L., & Huxley, A. F.
- Affiliations
- University of Cambridge (GB)
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1952-08-28
- Volume
- 117
- Issue
- 4
- Pages
- 500-544
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC1392413
- OpenAlex
- W1985940938
- Cited by
- 23,191
- References
- 0
- Citations by year
- 2026: 626 · 2025: 962 · 2024: 917 · 2023: 931 · 2022: 905 · 2021: 877 · 2020: 911 · 2019: 778 · 2018: 823 · 2017: 713 · 2016: 694 · 2015: 757 · 2014: 741 · 2013: 726 · 2012: 767
- FWCI
- 17.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- membrane currents, quantitative description, nerve conduction, nerve excitation, action potential, membrane excitability
- MeSH terms
- Axons, Humans
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