The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP
Open accessAbstract
Long-term depression (LTD) at cerebellar parallel fiber (PF)-Purkinje cell synapses must be balanced by long-term potentiation (LTP) to prevent saturation and allow reversal of motor learning. The only previously analyzed form of cerebellar LTP is induced by 4–8 Hz PF stimulation and requires cAMP but not nitric oxide. It is a poor candidate to reverse LTD because it is presynaptically expressed whereas LTD is postsynaptic. We now characterize a new form of LTP induced by 1 Hz PF stimulation for at least 300 s. This LTP is postsynaptically expressed, enhanced by chelating postsynaptic Ca 2+ , and depends on nitric oxide but not cAMP or cGMP, making it a plausible anti-Hebbian counterpart to Hebbian LTD.
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Cited by
Nanoscale Memristor Device as Synapse in Neuromorphic Systems
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“Recent results describe a previously unrecognized form of long-term potentiation in the cerebellar cortex (Lev-Ram et al., 2002) and a synaptic depotentiation in the hippocampus (Montgomery and Madison, 2002).”
Background
Metadata
- Authors
- Lev-Ram, V., Wong, S. T., Storm, D. R., & Tsien, R. Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-06-04
- Volume
- 99
- Issue
- 12
- Pages
- 8389-8393
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2057461097
- Cited by
- 320
- References
- 41
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Lev-Ram, V., Wong, S. T., Storm, D. R., & Tsien, R. Y. (2002). A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.122206399
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