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Role for the obesity-related FTO gene in the cellular sensing of amino acids
Open accessAbstract
SNPs in the first intron of FTO ( fat mass and obesity associated ) are strongly associated with human obesity. While it is not yet formally established that this effect is mediated through the actions of the FTO protein itself, loss of function mutations in FTO or its murine homologue Fto result in severe growth retardation, and mice globally overexpressing FTO are obese. The mechanisms through which FTO influences growth and body composition are unknown. We describe a role for FTO in the coupling of amino acid levels to mammalian target of rapamycin complex 1 signaling. These findings suggest that FTO may influence body composition through playing a role in cellular nutrient sensing.
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Cites
Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
Meyer, K. D., Saletore, Y., Zumbo, P., Elemento, O., Mason, C. E., & Jaffrey, S. R. (2012) · Cell · doi:10.1016/j.cell.2012.05.003 · Cited by 4,223
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106
Cited by
The genetics of obesity: From discovery to biology
Loos, R. J. F., & Yeo, G. S. H. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-021-00414-z · Cited by 1,291
Self-citationOxidative stress in obesity: A critical component in human diseases
Marseglia, L., Manti, S., D’Angelo, G., Nicotera, A., Parisi, E., Di Rosa, G., Gitto, E., & Arrigo, T. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms16010378 · Cited by 933
Recent advances in dynamic m 6 A RNA modification
Cao, G., Li, H.-B., Yin, Z., & Flavell, R. A. (2016) · Open Biology · doi:10.1098/rsob.160003 · Cited by 308
FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals
Qi, Q., Kilpeläinen, T. O., Downer, M. K., Tanaka, T., Smith, C. E., Sluijs, I., Sonestedt, E., Chu, A. Y., Renström, F., Lin, X., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu411 · Cited by 167
The proteins of mRNA modification: writers, readers, and erasers
Flamand, M. N., Tegowski, M., & Meyer, K. D. (2023) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052521-035330 · Cited by 164
Metadata
- Authors
- Gulati, P., Cheung, M. K., Antrobus, R., Church, C. D., Harding, H. P., Tung, Y.-C. L., Rimmington, D., Ma, M., Ron, D., Lehner, P. J., Ashcroft, F. M., Cox, R. D., Coll, A. P., O’Rahilly, S., & Yeo, G. S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-01-28
- Volume
- 110
- Issue
- 7
- Pages
- 2557-2562
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1984774548
- Cited by
- 171
- References
- 2
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gulati, P., Cheung, M. K., Antrobus, R., Church, C. D., Harding, H. P., Tung, Y.-C. L., Rimmington, D., Ma, M., Ron, D., Lehner, P. J., Ashcroft, F. M., Cox, R. D., Coll, A. P., O’Rahilly, S., & Yeo, G. S. H. (2013). Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1222796110
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