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Cited by 346

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Mast cells disrupt epithelial barrier function during enteric nematode infection

Open access
McDermott, Jacqueline R., Bartram, Ruth E., Knight, Pamela A., Miller, Hugh R. P., Garrod, David R., Grencis, Richard K.·2003·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1231488100
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Abstract

We have investigated the influence of mast cells on the barrier function of intestinal epithelium during nematode infection. Trichinella spiralis infection induces a strong type 2 cytokine-mediated inflammation, resulting in a critical mucosal mastocytosis that is known to mediate expulsion of the parasites from the intestine. The host response to infection is also characterized by an increase in mucosal leakiness. We show here that intestinal epithelial permeability is markedly elevated during infection, with kinetics that mirror the adaptive immune response to primary and secondary infection. Furthermore, we have identified degradation of the tight junction protein, occludin, thereby providing a mechanism for increased paracellular permeability during helminth infection. We further demonstrate by using anti-c- kit antibody and IL-9 transgenic mice that mast cells are directly responsible for increasing epithelial paracellular permeability and that mice deficient in a mast cell-specific protease fail to increase intestinal permeability and fail to expel their parasite burden. These results provide the mechanism whereby mucosal mast cells mediate parasite expulsion from the intestine.

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Metadata

Authors
McDermott, J. R., Bartram, R. E., Knight, P. A., Miller, H. R. P., Garrod, D. R., & Grencis, R. K.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2003-06-09
Volume
100
Issue
13
Pages
7761-7766
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1231488100
OpenAlex
W2158583133
Cited by
346
References
41
FWCI
11.69
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Mast cells disrupt epithelial barrier function during enteric nematode infection. https://app.cochat.ai/papers/10.1073/pnas.1231488100
The paper
McDermott, J. R., Bartram, R. E., Knight, P. A., Miller, H. R. P., Garrod, D. R., & Grencis, R. K. (2003). Mast cells disrupt epithelial barrier function during enteric nematode infection. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1231488100

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.