Cited by 831Parasites and Host InteractionsIL-33, ST2, and ILC PathwaysT-cell and B-cell Immunology

Diversity and dialogue in immunity to helminths

Allen, Judith E., Maizels, Rick M.·2011·Nature reviews. Immunology

Abstract

The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth (worm) parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.

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Crossref · 10.1038/nri2992

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Authors
Allen, J. E., & Maizels, R. M.
Affiliations
University of Edinburgh (GB)
Corresponding author
Maizels, Rick M.
Venue
Nature reviews. Immunology
Published
2011-05-25
Volume
11
Issue
6
Pages
375-388
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2018996778
Cited by
831
References
172
Citations by year
2026: 34 · 2025: 36 · 2024: 27 · 2023: 38 · 2022: 63 · 2021: 65 · 2020: 53 · 2019: 51 · 2018: 53 · 2017: 71 · 2016: 63 · 2015: 64 · 2014: 61 · 2013: 66 · 2012: 65
FWCI
9.06
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Funders
  • Wellcome Trust
  • Asthma and Lung UK
  • Fondation pour la Recherche Médicale
  • Medical Research Council
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
helminthiasis, Th2 immune response, protective immunity, immune cell types, immune molecules, immune regulation, persistent infection, sterile immunity, immune diversity
MeSH terms
Animals, Antigenic Variation, Helminthiasis, Helminths, Host-Parasite Interactions, Humans, Immunity, Genetic Variation, Cytokines, Th2 Cells, Models, Immunological

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